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Interleukin 7

IL-7, Interleukin-7
The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: Interleukin-2, CD4, CAN, IL-15, Interleukin-6
Papers using IL-7 antibodies
Standard operating procedures for describing and performing metabolic tests for glucose homeostasis in mice.
Shirihai Orian S., In PLoS ONE, 2009
... Heterozygous IL-7 transgenic mice on a C57BL/6J background ...
Simple and highly efficient BAC recombineering using galK selection.
Unutmaz Derya, In PLoS ONE, 2004
... Three strains of IL-7-promoter-ECFP (IL7promECFP) mice have been produced at NCI, Frederick MD and homozygous strains have been selected and maintained at NCI-Frederick, MD.Transgenic mice expressing an IL-7 ...
Surface Cathepsin B Protects Cytotoxic Lymphocytes from Self-destruction after Degranulation
Henkart Pierre A. et al., In The Journal of Experimental Medicine, 1998
... IgG, anti–mouse CD45, anti–CD4-FITC, anti–CD8-PE, anti–human CD28, avidin-FITC anti–mouse IgG-FITC, anti–mouse Fas (Jo-2), and recombinant IL-7 were purchased from BD Biosciences.
Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice
Hibi Toshifumi et al., In The Journal of Experimental Medicine, 1992
... IL-7 Transgenic Mice.
Papers on IL-7
Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women.
Kovacs et al., Baltimore, United States. In J Acquir Immune Defic Syndr, Mar 2016
Because interleukin 7 (IL-7) is a major cytokine controlling T-cell homeostasis, we analyzed the potential influence of HCV coinfection on circulating IL-7 levels in HIV-infected women before and after highly active antiretroviral therapy (HAART).
Group 3 innate lymphoid cells continuously require the transcription factor GATA-3 after commitment.
Zhu et al., Bethesda, United States. In Nat Immunol, Feb 2016
The transcription factor GATA-3 is indispensable for the development of all innate lymphoid cells (ILCs) that express the interleukin 7 receptor α-chain (IL-7Rα).
CD8αα TCRαβ Intraepithelial Lymphocytes in the Mouse Gut.
Yang et al., Chongqing, China. In Dig Dis Sci, Feb 2016
For instance, epithelial cells and nearby immune cells secrete a number of cytokines, including interleukin-15 (IL-15), IL-7, and transforming growth factor-β, resulting in an assortment of cellular responses, including activation of master transcription factors, cell proliferation, and cytokine secretion.
Decidual Control of Trophoblast Invasion.
Modi et al., Mumbai, India. In Am J Reprod Immunol, Feb 2016
The decidual secretions contain high amounts of pro-invasive factors that include IL-1β, IL-5, IL-6, IL-7, IL-8, IL-9, IL-13, IL-15, Eotaxin CCL11, IP-10 and RANTES, and anti-invasive factors IL-10, IL-12 and VEGF.
New insights of common gamma chain in hematological malignancies.
Hong et al., Yangsan, South Korea. In Cytokine, Jan 2016
UNASSIGNED: The common gamma chain (γc) receptor family of cytokines including interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21 has the common feature of sharing γc signaling subunit of their receptors.
Common gamma chain cytokines in combinatorial immune strategies against cancer.
Shanker et al., Nashville, United States. In Immunol Lett, Jan 2016
Common γ chain (γC) cytokines, namely IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 are important for the proliferation, differentiation, and survival of lymphocytes that display antitumor activity, thus stimulating considerable interest for the use of cytokines in cancer immunotherapy.
IL-7 signalling represses Bcl-6 and the TFH gene program.
Oestreich et al., Roanoke, United States. In Nat Commun, Dec 2015
Exposure of this potentially bi-potent cell population to IL-6 favours the TFH gene program, whereas IL-7 signalling represses TFH-associated genes including Bcl6 and Cxcr5, but not the TCM-related genes Klf2 and Sell.
Inflammatory profiles in canine intervertebral disc degeneration.
Meij et al., Utrecht, Netherlands. In Bmc Vet Res, Dec 2015
Cytokines interleukin (IL)-2, IL-6, IL-7, IL-8, IL-10, IL-15, IL-18, immune protein (IP)-10, tumor necrosis factor (TNF)-α, and granulocyte macrophage colony-stimulating factor (GM-CSF) were not detectable in the samples.
Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche.
Bozec et al., Erlangen, Germany. In Cell Metab, Dec 2015
At the same time, expression of genes such as Jag-1, SDF-1, and IL-7 forming the bone marrow niche was highly suppressed after HFD.
Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma.
Nagao et al., Tokyo, Japan. In Nat Med, Nov 2015
Hair follicle expression of IL-15 was required for CD8(+) TRM cells, and IL-7 for CD8(+) and CD4(+) TRM cells, to exert epidermotropism.
Histone reader BRWD1 targets and restricts recombination to the Igk locus.
Clark et al., Chicago, United States. In Nat Immunol, Oct 2015
Here we show that developmental downregulation of interleukin 7 (IL-7)-receptor signaling in small pre-B cells induced expression of the bromodomain-family member BRWD1, which was recruited to a specific epigenetic landscape at Igk dictated by pre-B cell receptor (pre-BCR)-dependent Erk activation.
Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point.
Walker et al., Durban, South Africa. In Immunity, Oct 2015
HIV-specific CD8(+) T cells secreted little interferon-γ, underwent rapid apoptosis, and failed to upregulate the interleukin-7 receptor, known to be important for T cell survival.
Somatotrope GHRH/GH/IGF-1 axis at the crossroads between immunosenescence and frailty.
Martens et al., Liège, Belgium. In Ann N Y Acad Sci, Sep 2015
IGF-1, a mediator of growth hormone (GH), was subsequently shown to induce interleukin-7 secretion in cultured primary human thymic epithelial cells.
Naïve T Cell Homeostasis Regulated by Stress Responses and TCR Signaling.
Murakami et al., Sapporo, Japan. In Front Immunol, 2014
The survival of naïve T cells is believed to require signals from TCR-pMHC interactions and cytokines such as IL-7.
Expression profile and kinetics of cytokines and chemokines in patients with chronic hepatitis C.
Zhu et al., Changchun, China. In Int J Clin Exp Med, 2014
In contrast, IFN-γ, IL-7, and IL-15 were remarkably decreased, especially in HCV genotype 1b infection.
The major isoforms of Bim contribute to distinct biological activities that govern the processes of autophagy and apoptosis in interleukin-7 dependent lymphocytes.
Khaled et al., Orlando, United States. In Biochim Biophys Acta, 2012
Loss of total Bim in interleukin-7-deprived T-cells resulted in delayed apoptosis.
IL-7 functionally segregates the pro-B cell stage by regulating transcription of recombination mediators across cell cycle.
Skok et al., New York City, United States. In J Immunol, 2012
We propose that activity of the IL-7/STAT5 pathway plays a critical protective role in pro-b cells development
An in vivo IL-7 requirement for peripheral Foxp3+ regulatory T cell homeostasis.
Park et al., Bethesda, United States. In J Immunol, 2012
we document a critical requirement for in vivo IL-7 in T cell maintenance and specifically in Foxp3(+) cell homeostasis.
IL-7 splicing variant IL-7δ5 induces human breast cancer cell proliferation via activation of PI3K/Akt pathway.
Zhu et al., Guangzhou, China. In Biochem Biophys Res Commun, 2012
these findings demonstrate that IL-7delta5 variant induces human breast cancer cell proliferation and cell cycle progression via activation of PI3K/Akt pathway.
PDE4 inhibition suppresses IL-17-associated immunity in dry eye disease.
Dana et al., Boston, United States. In Invest Ophthalmol Vis Sci, 2012
Topical cilomilast suppresses the generation of IL-17-associated immunity in experimental DED.
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