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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Interleukin 4 receptor

IL-4R, IL-4Ralpha, interleukin-4 receptor
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-4, IL-13, TH2, CAN, STAT6
Papers on IL-4R
Murine germinal center B cells require functional Fms-like tyrosine kinase 3 signaling for IgG1 class-switch recombination.
Bokarewa et al., Göteborg, Sweden. In Proc Natl Acad Sci U S A, Jan 2016
B cells from Flt3 ligand-deficient mice have impaired IL-4R signaling, with reduced phosphorylation of signal transducer and activator of transcription (Stat) 6, and demonstrate a failure to initiate CSR to IgG1 with low expression of γ1 germ-line transcripts, resulting in impaired IgG1 production.
Targeting IL4/IL4R for the treatment of epithelial cancer metastasis.
Fingleton et al., Nashville, United States. In Clin Exp Metastasis, Dec 2015
Interleukin-4 (IL4), a Th2 cytokine, and the IL4/IL4 receptor (IL4R) interaction have well defined roles in the immune system.
Loss of IL-4Rα-mediated PI3K signaling accelerates the progression of IgE/mast cell-mediated reactions.
Hogan et al., Cincinnati, United States. In Immun Inflamm Dis, Dec 2015
Clinical and experimental evidence indicate that polymorphisms within the interleukin 4 (IL-4) receptor (IL-4R) chain are sufficient for altered strength of IL-4/IL-13 signaling, leading to an exaggerated allergic inflammatory response and increase susceptibility to allergic phenotypes.
[Correlations of IL-4R gene polymorphism and serum IgE levels with asthma predictive index].
Muzhapaer et al., Ürümqi, China. In Zhongguo Dang Dai Er Ke Za Zhi, Dec 2015
OBJECTIVE: To study the correlations of IL-4R gene polymorphism and serum IgE levels with asthma predictive index (API) in children.
Identification, characterization, and targeting of IL-4 receptor by IL-4-Pseudomonas exotoxin in mouse models of anaplastic thyroid cancer.
Puri et al., Silver Spring, United States. In Discov Med, Nov 2015
Since interleukin-4 receptor (IL-4R) is overexpressed in human solid cancer, we examined expression of IL-4R in 50 cases of anaplastic thyroid cancer (ATC), 37 well-differentiated papillary cancer (WDPC), 35 well-differentiated follicular cancer of thyroid (WDFC), and 37 normal thyroid specimens by immunohistochemistry (IHC) and in-situ hybridization (ISH) techniques.
Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair.
Eming et al., Köln, Germany. In Immunity, Nov 2015
We have demonstrated that, during skin repair in mice, interleukin-4 receptor α (IL-4Rα)-dependent macrophage activation controlled collagen fibril assembly and that this process was important for effective repair while having adverse pro-fibrotic effects.
Enteric nematodes and the path to up-regulation of type 2 cytokines IL-4 and IL-13.
Zhao et al., Baltimore, United States. In Cytokine, Sep 2015
Both the immune and functional outcomes depend largely on IL-4/IL-13 signaling through STAT6, with a dominant role for IL-13 working through the type 2 IL-4 receptor (IL-4R).
Personalized Immunomodulatory Therapy for Atopic Dermatitis: An Allergist's View.
Nahm, Suwŏn, South Korea. In Ann Dermatol, Aug 2015
In recent clinical studies, monoclonal antibodies including the anti-interleukin-4 receptor antibody and anti-B cell antibody induced significant clinical improvements in patients with AD.
New pathogenic and therapeutic paradigms in atopic dermatitis.
Guttman-Yassky et al., New York City, United States. In Cytokine, Jun 2015
An IL-4R antagonist, dupilumab, is the first drug that shows great promise in phase II trials.
APOE-modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective.
LaDu et al., Chicago, United States. In J Neurochem, May 2015
We present data supporting the hypothesis that impaired apoE4 function modulates Aβ-induced effects on inflammatory receptor signaling, including amplification of detrimental (toll-like receptor 4-p38α) and suppression of beneficial (IL-4R-nuclear receptor) pathways.
Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy.
Chatila et al., Boston, United States. In Immunity, Apr 2015
We show that disease-susceptible (Il4ra(F709)) mice with enhanced interleukin-4 receptor (IL-4R) signaling exhibited STAT6-dependent impaired generation and function of mucosal allergen-specific Treg cells.
Dupilumab in persistent asthma with elevated eosinophil levels.
Pirozzi et al., Pittsburgh, United States. In N Engl J Med, 2013
We evaluated the efficacy and safety of dupilumab (SAR231893/REGN668), a fully human monoclonal antibody to the alpha subunit of the interleukin-4 receptor, in patients with persistent, moderate-to-severe asthma and elevated eosinophil levels.
Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma.
Ray et al., Pittsburgh, United States. In Nat Med, 2012
Virus infection induced GATA-3 expression and T helper type 2 (T(H)2) cytokine production in forkhead box P3 (FOXP3)(+) T(reg) cells and compromised the suppressive function of pulmonary T(reg) cells in a manner that was dependent on interleukin-4 receptor α (IL-4Rα) expression in the host.
Allergic airway disease is unaffected by the absence of IL-4Rα-dependent alternatively activated macrophages.
Brombacher et al., Cape Town, South Africa. In J Allergy Clin Immunol, 2012
LysM(cre)IL-4Ralpha(-/lox) mice and littermate controls also developed similar responses in acute ovalbumin- and house dust mite-induced allergic airway disease
Effects of cytokine and cytokine receptor gene variation on high anti-HB titers: following up on Taiwan's neonatal hepatitis B immunization program.
Tsai et al., Taiwan. In Clin Chim Acta, 2012
Genetic determinants IL-4 and IL-4R, may contribute to high anti-hepatitis B titers in immune responses to hepatitis B vaccinations.
IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor α antagonist.
Bleecker et al., Winston-Salem, United States. In J Allergy Clin Immunol, 2012
Subjects homozygous for the IL4RA rs8832 common G allele randomized to pitrakinra had decreased asthma exacerbations and decreased nocturnal awakenings and activities limited by asthma.
Tumor-induced myeloid-derived suppressor cell function is independent of IFN-γ and IL-4Rα.
Ostrand-Rosenberg et al., Baltimore, United States. In Eur J Immunol, 2012
neither IFN-gamma nor IL-4R-alpha is a key regulator of Myeloid-derived suppressor cells and targeting these molecules is unlikely to significantly alter MDSC accumulation or function.
Association of interleukin 4 (-590 T/C) and interleukin 4 receptor (Q551R A/G) gene polymorphisms with acne vulgaris.
Settin et al., Saudi Arabia. In Ann Saudi Med, 2012
This study provides evidence for a significant association of IL-4R (Q551R A/G) genetic polymorphisms with the susceptibility rather than the severity of acne vulgaris
An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection.
Gause et al., Newark, United States. In Nat Med, 2012
We found that IL-17 initially contributed to inflammation and lung damage, whereas subsequent IL-4 receptor (IL-4R) signaling reduced elevations in IL-17 mRNA levels, enhanced the expression of insulin-like growth factor 1 (IGF-1) and IL-10 and stimulated the development of M2 macrophages, all of which contributed to the rapid resolution of tissue damage.
Expression of Cell Surface Receptors on Human Glioblastoma Xenograft Model in NOD/SCID Mouse.
Huh et al., In Cancer Res Treat, 2002
Immunohistochemical studies were performed on implanted tumor nodules (n=8) using antibodies against CD71, EGFR, IGF-IRalpha, CXCR4 and IL-4Ralpha.
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