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Interleukin 29

IL-29, IFN-lambda1, IFN-lambda
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-28A, IL-10, CAN, Interferon-beta, HAD
Papers on IL-29
PIV-3 blocks antiviral mediators downstream of the IFN-λR by modulating Stat1 phosphorylation.
Sacco et al., Ames, United States. In J Virol, Jan 2016
Here we show that message levels of IL-29 are significantly increased during PIV-3 infection, yet downstream antiviral signaling molecules are not upregulated to levels similar to the positive control.
Induction and Antagonism of Antiviral Responses in Respiratory Syncytial Virus-Infected Pediatric Airway Epithelium.
Power et al., Ireland. In J Virol, Jan 2016
We found that RSV induces a potent antiviral state in WD-PBECs that was mediated in part by secreted factors, including interferon lambda 1 (IFN-λ1)/interleukin-29 (IL-29).
Dexamethasone decreases IL-29 expression in house dust mite-stimulated human bronchial epithelial cells.
Yu et al., Guangzhou, China. In J Huazhong Univ Sci Technolog Med Sci, Dec 2015
The aim of this study was to explore the effect of IL-29 on the progression of airway allergic disease by detecting the level of IL-29 in airway allergic cell models stimulated by house dust mite (HDM) in the presence or absence of dexamethasone (DEX).
Interleukin-29 induces epithelial production of CXCR3A ligands and T-cell infiltration.
Wolk et al., Berlin, Germany. In J Mol Med (berl), Dec 2015
Recently, we demonstrated that Th17-cells produce interleukin (IL)-29 and that IL-29 is highly present in psoriatic lesions.
IFN-lambda therapy: current status and future perspectives.
Cohen-Solal et al., United States. In Drug Discov Today, Dec 2015
UNASSIGNED: Interferon-lambda (IFN-λ), the most recently described type III IFN, plays a crucial part by acting on specific cell types, controlling viral infections and establishing robust innate immunity against cancer.
Interleukin-29 induces receptor activator of NF-κB ligand expression in fibroblast-like synoviocytes via MAPK signaling pathways.
Wang et al., Nanjing, China. In Int J Rheum Dis, Nov 2015
AIM: We previously reported that interleukin-29 (IL-29) was highly expressed in the blood and synovium of rheumatoid arthritis (RA) patients and contributed to synovial inflammation by induction of proinflammatory cytokine production.
Direct-acting Antivirals and Host-targeting Agents against the Hepatitis A Virus.
Yokosuka et al., Chiba, Japan. In J Clin Transl Hepatol, Oct 2015
Among the HTAs, amantadine and interferon-lambda 1 (IL-29) inhibit HAV IRES-mediated translation and HAV replication.
Interferon-λ: Immune Functions at Barrier Surfaces and Beyond.
Diamond et al., Saint Louis, United States. In Immunity, Aug 2015
When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs (IFN-α and IFN-β) via the induction of IFN-stimulated genes (ISGs).
[Site-directed mutagenesis of human IL-29 and antineoplastic activity of the recombinant human IL-29 variant].
Wu et al., In Sheng Wu Gong Cheng Xue Bao, May 2015
To explore the anti-tumor proliferation activity of human interleukin-29 (hIL-29) variant and based on bioinformatics analyzed data of hIL-29, a mutant gene hIL-29(mut33,35) was amplified by site-directed mutagenesis and megaprimer PCR.
Role of Interferon-λ in Allergic Asthma.
Finotto et al., Erlangen, Germany. In J Innate Immun, 2014
Asthmatic patients, without a detectable viral infection show an inverse correlation between IL-28 and IL-29 mRNA levels and severity of allergic responses in the airways.
IL-10 function, regulation, and in bacterial keratitis.
McClellan et al., Detroit, United States. In J Ocul Pharmacol Ther, 2014
The interleukin (IL)-10 family of cytokines, composed of 9 members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and 3 distantly related members, IL-28A, IL-28B, and IL-29, plays a central role in this regulation.
A mechanistic role for type III IFN-λ1 in asthma exacerbations mediated by human rhinoviruses.
Polack et al., Nashville, United States. In Am J Respir Crit Care Med, 2012
modulates asthma exacerbations caused by human rhinoviruses
Epigenetic changes mediated by microRNA miR29 activate cyclooxygenase 2 and lambda-1 interferon production during viral infection.
Zhu et al., Wuhan, China. In J Virol, 2012
MiR29 suppresses DNMT activity and thus induces expression of COX2 and PGE2 during influenza A virus infection.
Regulation of IFN-λ1 promoter activity (IFN-λ1/IL-29) in human airway epithelial cells.
Gallagher et al., United States. In J Immunol, 2012
We investigated the regulation of IFN-lambda1 expression in human airway epithelial cells
HHV-6B induces IFN-lambda1 responses in cord plasmacytoid dendritic cells through TLR9.
Eriksson et al., Göteborg, Sweden. In Plos One, 2011
Inactivated HHV-6B is a strong inducer of IFN-lambda1 in plasmacytoid dendritic cells and this induction is TLR9-dependent.
Hepatitis B virus induces a novel inflammation network involving three inflammatory factors, IL-29, IL-8, and cyclooxygenase-2.
Wu et al., Wuhan, China. In J Immunol, 2011
Expression levels of IL-29, IL-8, and cyclooxygenase (COX)-2 are elevated in patients with hepatitis B virus (HBV) infection and in HBV-transfected hepatoma cells.
Regulation and functions of the IL-10 family of cytokines in inflammation and disease.
Hymowitz et al., San Francisco, United States. In Annu Rev Immunol, 2010
The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and the more distantly related IL-28A, IL-28B, and IL-29.
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance.
Goldstein et al., Durham, United States. In Nature, 2009
Here we report that a genetic polymorphism near the IL28B gene, encoding interferon-lambda-3 (IFN-lambda-3), is associated with an approximately twofold change in response to treatment, both among patients of European ancestry (P = 1.06 x 10(-25)) and African-Americans (P = 2.06 x 10(-3)).
Interleukin-10 and related cytokines and receptors.
Fisher et al., United States. In Annu Rev Immunol, 2003
The Class 2 alpha-helical cytokines consist of interleukin-10 (IL-10), IL-19, IL-20, IL-22, IL-24 (Mda-7), and IL-26, interferons (IFN-alpha, -beta, -epsilon, -kappa, -omega, -delta, -tau, and -gamma) and interferon-like molecules (limitin, IL-28A, IL-28B, and IL-29).
IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.
Donnelly et al., Newark, United States. In Nat Immunol, 2003
closely positioned genes on human chromosome 19 encode distinct but paralogous proteins, which we designate interferon-lambda1 (IFN-lambda1), IFN-lambda2 and IFN-lambda3
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