Neutrophil proteases alter the interleukin-22-receptor-dependent lung antimicrobial defence.
Tours, France. In Eur Respir J, Sep 2015
We hypothesised that neutrophils secrete proteases that may have adverse effects in COPD, by altering the IL-22 receptor (IL-22R)-dependent signalling.Using in vitro and in vivo approaches as well as reverse transcriptase quantitative PCR, flow cytometry and/or Western blotting techniques, we first showed that pathogens such as the influenza virus promote IL-22R expression in human bronchial epithelial cells, whereas Pseudomonas aeruginosa, bacterial lipopolysaccharide or cigarette smoke do not.
Therapeutic opportunities of the IL-22-IL-22R1 system.
Berlin, Germany. In Nat Rev Drug Discov, 2014
Data obtained over the past few years indicate that the IL-22-IL-22 receptor subunit 1 (IL-22R1) system has a high potential clinical relevance in psoriasis, ulcerative colitis, graft-versus-host disease, certain infections and tumours, as well as in liver and pancreas damage.
A novel role for IL-22R1 as a driver of inflammation.
Frederick, United States. In Blood, 2011
This study documents a previously unknown role of IL-22R1 in inflammation and identifies the involvement of IL-22R1/IL-22 in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma