Adaptor and clathrin exchange at the plasma membrane and trans-Golgi network
In Traffic (Copenhagen, Denmark), 2002
... (MBL International, Woburn, MA, USA), mouse monoclonal anti-GFP (ab1218; Abcam, Cambridge, MA, USA), mouse monoclonal anti-IL2 Receptor alpha (Tac) (143–13; Abcam) and mouse monoclonal anti-annexin-II ...
The common γ-chain cytokine receptor: tricks-and-treats for T cells.
Bethesda, United States. In Cell Mol Life Sci, Nov 2015
UNASSIGNED: Originally identified as the third subunit of the high-affinity IL-2 receptor complex, the common γ-chain (γc) also acts as a non-redundant receptor subunit for a series of other cytokines, collectively known as γc family cytokines.
Comorbidity between depression and inflammatory bowel disease explained by immune-inflammatory, oxidative, and nitrosative stress; tryptophan catabolite; and gut-brain pathways.
Badalona, Spain. In Cns Spectr, Sep 2015
Common IO&NS underpinning between both disorders is evidenced by increased pro-inflammatory cytokine levels, eg, interleukin-1 (IL-1) and tumor necrosis factor-α, IL-6 trans-signalling; Th-1- and Th-17-like responses; neopterin and soluble IL-2 receptor levels; positive acute phase reactants (haptoglobin and C-reactive protein); lowered levels of negative acute phase reactants (albumin, transferrin, zinc) and anti-inflammatory cytokines (IL-10 and transforming growth factor-β); increased O&NS with damage to lipids, proteinsm and DNA; increased production of nitric oxide (NO) and inducible NO synthase; lowered plasma tryptophan but increased TRYCAT levels; autoimmune responses; and increased bacterial translocation.
IL-2: Change Structure … Change Function.
San Francisco, United States. In Immunity, Jun 2015
In this issue of Immunity, Spangler et al. and Mitra et al. demonstrate how structural changes in the IL-2 molecule alter interactions with the IL-2 receptor, leading to differential cellular targeting and biochemical responses and selective immune consequences.