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Interleukin 1 receptor-like 2

IL-1Rrp2, IL1RL2
The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-1beta, IL-1ra, IL-1F9, IL-1F6, IL-18
Papers on IL-1Rrp2
Alarmin function of cathelicidin antimicrobial peptide LL37 through IL-36γ induction in human epidermal keratinocytes.
Aiba et al., Sendai, Japan. In J Immunol, 2014
Pretreatment with small interfering RNA against IL36γ and IL-36R IL36R/IL1RL2 and IL1RAP suppressed LL37-dependent IL8, CXCL1, CXCL10/IP10, and CCL20 production in keratinocytes, suggesting that the alarmin function of LL37 was partially dependent on IL-36γ and its receptors.
Expression of IL-1Rrp2 by human myelomonocytic cells is unique to DCs and facilitates DC maturation by IL-1F8 and IL-1F9.
Foster et al., Nottingham, United Kingdom. In Eur J Immunol, 2012
Expression of IL-1Rrp2 by sone dendritic cell subsets may have an important function in the human immune response in vivo via its role in differentiation of inflammatory Th1 lymphocytes.
IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist.
Dinarello et al., Aurora, United States. In Proc Natl Acad Sci U S A, 2012
These data provide evidence that IL-38 binds to the IL-36R, as does IL-36Ra.[IL-38, IL-36R]
Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity.
Sims et al., Seattle, United States. In J Biol Chem, 2012
IL-36α, IL-36β, and IL-36γ (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2 (IL-1RL2) and IL-1RAcP.
IL-36R ligands are potent regulators of dendritic and T cells.
Gabay et al., Genève, Switzerland. In Blood, 2011
These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1, whereas IL-36Ra (IL-1F5) acts as an IL-36R antagonist (IL-36Ra).
IL-37: a new anti-inflammatory cytokine of the IL-1 family.
Dinarello et al., Pisa, Italy. In Eur Cytokine Netw, 2011
In contrast, IL-1 receptor antagonist (IL-1Ra, IL-1F3) and the receptor antagonist binding to IL-1Rrp2 (IL-36Ra, IL-1F5) reduce inflammation by blocking the binding of the agonist receptor ligands.
Interleukin-1 family member 9 stimulates chemokine production and neutrophil influx in mouse lungs.
LeVine et al., Gainesville, United States. In Am J Respir Cell Mol Biol, 2011
IL-1F9 signals through IL-1 receptor-related protein 2 (IL-1Rrp2/IL-1RL2), which is distinct from IL-1RI.
Association between interleukin 1 gene cluster polymorphisms and bilateral distal interphalangeal osteoarthritis.
Leino-Arjas et al., Helsinki, Finland. In J Rheumatol, 2009
We genotyped 10 single-nucleotide polymorphisms (SNP) in the IL1R1, IL1RL2, IL1A, IL1B, and IL1RN genes using polymerase chain reaction-based methods.
The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress.
O'Neill, Dublin, Ireland. In Immunol Rev, 2008
We now know a great deal more about this superfamily, with the description of novel IL-1 family members such as IL-1F6 signaling via IL-1Rrp2 and IL33 signaling via ST2.
Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation.
Peschon et al., Seattle, United States. In J Exp Med, 2007
IL1F6 transgenic mice exhibit skin abnormalities that are dependent on IL-1Rrp2 and IL-1RAcP, which are two members of the IL-1R family.
The expanding family of interleukin-1 cytokines and their role in destructive inflammatory disorders.
Taylor et al., Newcastle upon Tyne, United Kingdom. In Clin Exp Immunol, 2007
IL-1F6, IL-1F8 and Il-1F9 are agonists and, along with their receptor IL-1Rrp2, are highly expressed in epithelial cells suggesting a role in immune defence in the skin and the gastrointestinal (GI) tract including the mouth.
Lack of association between IL-1beta/alpha gene polymorphisms and temporal lobe epilepsy with hippocampal sclerosis.
Buyru et al., İstanbul, Turkey. In Seizure, 2006
IL-1alpha and IL-1beta gene polymorphisms do not act as a strong susceptibility factor for MTLE-HS in individuals of Turkish ancestry
The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes.
Gabay et al., Genève, Switzerland. In Arthritis Res Ther, 2005
Human synovial fibroblasts (hSFs) and human articular chondrocytes (hACs) expressed the IL-1F8 receptor (IL-1Rrp2) and produced pro-inflammatory mediators in response to recombinant IL-1F8.
Regulation of expression of the novel IL-1 receptor family members in the mouse brain.
Rothwell et al., Manchester, United Kingdom. In J Neurochem, 2005
The discovery of new orphan members of the IL-1 receptor superfamily (including ST2/T1, IL-1Rrp2, TIGIRR1 and -2, SIGGIR, IL-18Ralpha and IL-18Rbeta) has increased speculation that alternative IL-1 ligands signalling pathways exist in the brain.
The interleukin-1-related cytokine IL-1F8 is expressed in glial cells, but fails to induce IL-1beta signalling responses.
Pinteaux et al., Manchester, United Kingdom. In Cytokine, 2005
The putative new interleukin (IL)-1 family member IL-1F8 (IL-1eta, IL-1H2) has been shown recently to activate mitogen activated protein kinases (MAPKs), extracellular signal-regulated protein kinase (ERK1/2) and c-Jun N-terminal kinase (JNK), and nuclear factor-kappa B (NFkappa B) via a mechanism that requires IL-1Rrp2 expression in cell lines.
Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs.
Sims et al., Seattle, United States. In J Biol Chem, 2004
Recently, it was reported that IL-1F9 activated NF-kappaB through the orphan receptor IL-1 receptor (IL-1R)-related protein 2 (IL-1Rrp2) in Jurkat cells (Debets, R., Timans, J. C., Homey, B., Zurawski, S., Sana, T. R., Lo, S., Wagner, J., Edwards, G., Clifford, T., Menon, S., Bazan, J. F., and Kastelein, R. A. (2001) J. Immunol.
IL-1Rrp2 expression and IL-1F9 (IL-1H1) actions in brain cells.
Pinteaux et al., Manchester, United Kingdom. In J Neuroimmunol, 2003
The aim of the present study was therefore to investigate expression of IL-1Rrp2 and to determine if IL-1F9 induces known IL-1 signaling pathways in the different cell types of the mouse brain in culture.
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