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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Interleukin 19

IL-19, interleukin-19
The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-10, P28, FISP, IL-21, IL-26
Papers on IL-19
The expression quantitative trait loci in immune pathways and their effect on cutaneous melanoma prognosis.
Kirchhoff et al., New York City, United States. In Clin Cancer Res, Feb 2016
RESULTS: We identified highly significant associations with better melanoma OS for rs6673928, impacting IL19 expression (HR 0.56, 95% CI 0.41-0.77;
Interleukin-17A as a Biomarker for Bovine Tuberculosis.
Larsen et al., Ames, United States. In Clin Vaccine Immunol, Jan 2016
Using RNA-seq, numerous Th17-associated cytokine genes (including IL-17A, IL-17F, IL-22, IL-19, and IL-27) were up-regulated > 9 fold in response to purified protein derivative stimulation of peripheral blood mononuclear cells from experimentally M. bovis-infected cattle.
Interleukin-19 and angiopoietin-2 can enhance angiogenesis of diabetic complications.
Meng et al., Dongkan, China. In J Diabetes Complications, Dec 2015
UNASSIGNED: This study was to investigate the role of interleukin-19 (IL-19) and angiopoietin-2 (Ang-2) in angiogenesis of type 2 diabetes (T2DM).
[Increased IL-19 level in peripheral blood of patients with allergic rhinitis is related with clinical severity].
Hong et al., Chongqing, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, Nov 2015
To investigate the level of interleukin-19 (IL-19) in the peripheral blood of the patients with allergic rhinitis (AR) and reveal the possible role of IL-19 in the development of disease.
Modulation of CD4+ and CD8+ T-Cell Function by Interleukin 19 and Interleukin 24 During Filarial Infections.
Babu et al., Chennai, India. In J Infect Dis, Nov 2015
UNASSIGNED: Interleukin 19 (IL-19) and interleukin 24 (IL-24) are cytokines that are highly expressed in filarial infections.
The IL-20 subfamily of cytokines--from host defence to tissue homeostasis.
Ouyang et al., San Francisco, United States. In Nat Rev Immunol, 2014
The interleukin-20 (IL-20) subfamily of cytokines comprises IL-19, IL-20, IL-22, IL-24 and IL-26.
Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine Family.
Vannay et al., Budapest, Hungary. In Mediators Inflamm, 2014
In the present review we provide an overview of the common key mediators of organ fibrosis highlighting the role of interleukin-10 (IL-10) cytokine family members (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26), which recently came into focus as tissue remodeling-related inflammatory cytokines.
Integrated Genome-wide association and hypothalamus eQTL studies indicate a link between the circadian rhythm-related gene PER1 and coping behavior.
Wimmers et al., Germany. In Sci Rep, 2014
Eight genes (ASGR1, CPAMD8, CTC1, FBXO39, IL19, LOC100511790, RAD51B, UBOX5) had cis- and five (RANGRF, PER1, PDZRN3, SH2D4B, LONP2) had trans-expressionQTL.
IL-10 function, regulation, and in bacterial keratitis.
McClellan et al., Detroit, United States. In J Ocul Pharmacol Ther, 2014
The interleukin (IL)-10 family of cytokines, composed of 9 members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and 3 distantly related members, IL-28A, IL-28B, and IL-29, plays a central role in this regulation.
Therapeutic targets for rheumatoid arthritis: Progress and promises.
Rasheed et al., In Autoimmunity, 2014
In the present review, we focus on IL-7, IL-18, IL-32 and IL-10 family of cytokines (IL-19, IL-20 and IL-22) as they are implicated in contributing to the pathogenesis of RA, which could be targeted and offer new therapeutic options for RA therapy.
Interleukins (ILs), a fascinating family of cytokines. Part I: ILs from IL-1 to IL-19.
Delsante et al., In Theor Biol Forum, 2013
The biology and functions of the hitherto identified human ILs are reviewed and discussed: in this first section of the article, ILs from IL-1 to IL-19 are presented.
Signaling via the IL-20 receptor inhibits cutaneous production of IL-1β and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus.
Datta et al., Bethesda, United States. In Nat Immunol, 2013
Interleukin 19 (IL-19), IL-20 and IL-24 signal through type I and type II IL-20 receptors and are associated with inflammatory skin diseases such as psoriasis and atopic dermatitis.
Increased expression of IL-19 in the epithelium of patients with chronic rhinosinusitis and nasal polyps.
Gjomarkaj et al., Palermo, Italy. In Allergy, 2012
IL-19 is overexpressed in the epithelium in Chronic rhinosinusitis with nasal polyps and increases epithelial cell proliferation.
Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway.
Satsangi et al., Edinburgh, United Kingdom. In Inflamm Bowel Dis, 2012
Methylation in IL-19 is associated with Crohn's disease.
Upregulated IL-19 in breast cancer promotes tumor progression and affects clinical outcome.
Chang et al., Taipei, Taiwan. In Clin Cancer Res, 2012
IL-19 is pivotal in the pathogenesis of breast cancer.
Interleukin-19 (IL-19) induces heme oxygenase-1 (HO-1) expression and decreases reactive oxygen species in human vascular smooth muscle cells.
Autieri et al., Philadelphia, United States. In J Biol Chem, 2012
Interleukin-19 (IL-19) induces heme oxygenase-1 (HO-1) expression and decreases reactive oxygen species in human vascular smooth muscle cells.
Interleukin-19: a constituent of the regulome that controls antigen presenting cells in the lungs and airway responses to microbial products.
Grunig et al., New York City, United States. In Plos One, 2010
endogenous IL-19 is a constituent of the regulome that controls both processes in vivo
Regulation and functions of the IL-10 family of cytokines in inflammation and disease.
Hymowitz et al., San Francisco, United States. In Annu Rev Immunol, 2010
The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and the more distantly related IL-28A, IL-28B, and IL-29.
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
Type 1 Diabetes Genetics Consortium et al., Cambridge, United Kingdom. In Nat Genet, 2009
The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.
Interleukin-10 and related cytokines and receptors.
Fisher et al., United States. In Annu Rev Immunol, 2003
The Class 2 alpha-helical cytokines consist of interleukin-10 (IL-10), IL-19, IL-20, IL-22, IL-24 (Mda-7), and IL-26, interferons (IFN-alpha, -beta, -epsilon, -kappa, -omega, -delta, -tau, and -gamma) and interferon-like molecules (limitin, IL-28A, IL-28B, and IL-29).
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