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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Interleukin 17 receptor B

IL-17RB, IL17BR, IL-17Rh1, IL-17 receptor B, interleukin-17B receptor, EVI27, CRL4
The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, DTL, IL-25, IL-17, PCNA
Papers on IL-17RB
MMSET is dynamically regulated during cell-cycle progression and promotes normal DNA replication.
Lou et al., Rochester, United States. In Cell Cycle, Feb 2016
In this study, we report that MMSET is degraded during S phase in a cullin-ring ligase 4-Cdt2 (CRL4(Cdt2)) and proteasome-dependent manner.
Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.
Kutay et al., Zürich, Switzerland. In Cell Rep, Jan 2016
We demonstrate a role for the vertebrate-specific factor RBIS in ribosome synthesis, uncover a requirement for the CRL4 E3 ubiquitin ligase in nucleolar ribosome biogenesis, and reveal that intracellular glutamine synthesis supports 40S subunit production.
The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications.
Ren et al., Tianjin, China. In Oncotarget, Jan 2016
CRL4 E3 ubiquitin ligase, as one member of CRLs family, consists of a RING finger domain protein, cullin4 (CUL4) scaffold protein and DDB1-CUL4 associated substrate receptors.
Interleukin (IL)-25: Pleiotropic roles in asthma.
Sun et al., Beijing, China. In Respirology, Jan 2016
Growing evidence from experimental and clinical studies indicates that the expression of IL-25 and its cognate receptor, IL-17RB/RA, is markedly upregulated in asthmatic conditions.
IL-25/IL-33-responsive TH2 cells characterize nasal polyps with a default TH17 signature in nasal mucosa.
Till et al., London, United Kingdom. In J Allergy Clin Immunol, Jan 2016
RESULTS: IL-25 receptor (IL-17RB)-expressing TH2 effector cells were identified in nasal polyp tissue but not the healthy nasal mucosa or periphery.
Lenalidomide: deciphering mechanisms of action in myeloma, myelodysplastic syndrome and beyond.
Ebert et al., Boston, United States. In Curr Opin Cell Biol, Dec 2015
Lenalidomide and its related 'analogues' modulate the substrate specificity of the CRL4(CRBN) E3 ubiquitin ligase complex.
IL-25 and IL-33 induce Type 2 inflammation in basophils from subjects with allergic asthma.
Gauvreau et al., Hamilton, Canada. In Respir Res, Dec 2015
Peripheral blood and sputum samples were collected at pre-challenge, 7 h, and 24 h post-challenge to measure basophil expression of IL-17RB, ST2, and intracellular IL-25.
Assessment of the prognostic and predictive utility of the Breast Cancer Index (BCI): an NCIC CTG MA.14 study.
Pollak et al., United States. In Breast Cancer Res, Dec 2015
We evaluated the prognostic value of the Breast Cancer Index (BCI), a continuous risk index based on a combination of HOXB13:IL17BR and molecular grade index, in women with early breast cancer treated with either tamoxifen alone or tamoxifen plus octreotide in the NCIC MA.14 phase III clinical trial (
The novel mechanism of lenalidomide activity.
Ebert et al., Boston, United States. In Blood, Dec 2015
Lenalidomide acts by a novel drug mechanism-modulation of the substrate specificity of the CRL4(CRBN) E3 ubiquitin ligase.
Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B.
Zhou et al., United States. In Gene, Dec 2015
Both act as scaffolding proteins for modular cullin RING ligase 4 (CRL4) complexes which promote the ubiquitination of a variety of substrates.
Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.
Ebert et al., Boston, United States. In Nature, Aug 2015
Here, we demonstrate that lenalidomide induces the ubiquitination of casein kinase 1A1 (CK1α) by the E3 ubiquitin ligase CUL4-RBX1-DDB1-CRBN (known as CRL4(CRBN)), resulting in CK1α degradation.
Interleukin-17B Antagonizes Interleukin-25-Mediated Mucosal Inflammation.
Dong et al., Chicago, United States. In Immunity, May 2015
IL-17B and IL-25, both binding to the interleukin-17 receptor B (IL-17RB), were upregulated in their expression after acute colonic inflammation.
Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.
Thomä et al., Basel, Switzerland. In Nature, 2014
IMiDs target the E3 ubiquitin ligase CUL4-RBX1-DDB1-CRBN (known as CRL4(CRBN)) and promote the ubiquitination of the IKAROS family transcription factors IKZF1 and IKZF3 by CRL4(CRBN).
Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus.
Giancotti et al., New York City, United States. In Cancer Cell, 2014
It is currently unclear whether Merlin/NF2 suppresses tumorigenesis by activating upstream components of the Hippo pathway at the plasma membrane or by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus.
CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins.
Fan et al., Hangzhou, China. In Science, 2014
We found that a cullin-ring finger ligase-4 (CRL4) complex was crucial in this process.
Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathology.
Lukacs et al., Ann Arbor, United States. In Nat Med, 2012
data establish IL-25 and its receptor IL-17RB as targets for innate and adaptive immune responses in chronic allergic airway disease and identify T2M cells as a new steroid-resistant cell population
Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2.
Gratchev et al., Mannheim, Germany. In Immunobiology, 2012
In summary we established a new mechanism of IL17RB regulation-Smurf2 dependent degradation of its adaptor protein DAZAP2.
Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses.
Ying et al., London, United Kingdom. In J Allergy Clin Immunol, 2011
Allergen provocation induces functionally relevant, increased expression of IL-25 and its receptor in the asthmatic bronchial mucosa and dermis of sensitized atopic subjects.
Upregulation of IL17RB during natural allergen exposure in patients with seasonal allergic rhinitis.
Fujieda et al., Tsukuba, Japan. In Allergol Int, 2011
The present study identified upregulation of IL17RB during natural allergen exposure in patients with seasonal allergic rhinitis (SAR).
The CD4+ T-cell transcriptome and serum IgE in asthma: IL17RB and the role of sex.
Raby et al., Boston, United States. In Bmc Pulm Med, 2010
Results indicate that IL17RB may be the only gene expressed in CD4+ T cells whose transcript measurement is correlated with the variation in IgE level in asthmatics, but correlation between IL17RB and IgE was restricted to males only.
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