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Interleukin 13 receptor, alpha 1

IL-13Ralpha1, IL-13R, IL-13Ralpha
The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-13, IL-4R, IL-4, IL-13Ralpha2, STAT6
Papers on IL-13Ralpha1
Mac-1 Regulates IL-13 Activity in Macrophages by Directly Interacting with IL-13Rα1.
Zhang et al., Baltimore, United States. In J Biol Chem, Sep 2015
In this study, we report the identification of IL-13Rα1, a component of the IL-13 receptor (IL-13R), as a novel ligand of integrin Mac-1, using a co-evolution-based algorithm.
Unique IL-13Rα2-based HIV-1 vaccine strategy to enhance mucosal immunity, CD8(+) T-cell avidity and protective immunity.
Jackson et al., Canberra, Australia. In Mucosal Immunol, 2013
We believe our novel IL-13R cytokine trap vaccine strategy offers great promise for not only HIV-1, but also as a platform technology against range of chronic infections that require strong sustained high-avidity mucosal/systemic immunity for protection.
The innate antiviral response upregulates IL-13 receptor α2 in bronchial fibroblasts.
Andrews et al., Southampton, United Kingdom. In J Allergy Clin Immunol, 2013
We have previously shown that the decoy receptor IL-13 receptor (IL-13R) α2 attenuates responses of fibroblasts to IL-13.
Expression of interleukin-4 and interleukin-13 and their receptors in colorectal cancer.
Kornmann et al., Ulm, Germany. In Int J Colorectal Dis, 2012
Nothing is presently known about expression of these cytokines and their receptors (IL-4R and IL-13R) in colorectal cancer.
Gene-gene interactions between candidate gene polymorphisms are associated with total IgE levels in Korean children with asthma.
Hong et al., Seoul, South Korea. In J Asthma, 2012
In Korean asthmatic children, increased serum IgE level was a multi-locus interaction between IL-4Ralpha, IL-13, IL-13Ralpha1, CD14, and CTLA4 polymorphisms. The combination of CTLA4/IL-13 and IL-13/IL-13Ralpha1 polymorphisms showed strong synergistic effects.
Cytotoxic T lymphocyte trafficking and survival in an augmented fibrin matrix carrier.
Chen et al., Duarte, United States. In Plos One, 2011
The interleukin-13 receptor alpha 2 specific (IL-13R alpha2) T cells that traveled out of the fibrin clot retained the capacity to kill U251 glioma cells.
Single cell analysis of ligand binding and complex formation of interleukin-4 receptor subunits.
Schwille et al., Dresden, Germany. In Biophys J, 2011
The data provide evidence for codiffusion of IL-4-A647 bound IL-4Ralpha and the type II subunit IL-13Ralpha1 fused to enhanced green fluorescent protein.
IL-13 receptor α1 differentially regulates aeroallergen-induced lung responses.
Munitz et al., Cincinnati, United States. In J Immunol, 2011
IL-13Ralpha1 is the key receptor mediating airway hypersensitivity responses, mucus production, and transforming growth factor (TGF)-beta induction in response to aeroallergens.
Association of polymorphisms in genes encoding IL-4, IL-13 and their receptors with atopic dermatitis in a Korean population.
Yang et al., Cleveland, United States. In Exp Dermatol, 2011
the combination of rs3091307 GG/ rs2265753 GG (IL-13/IL-13Ralpha1) conveyed a significantly higher risk for developing atopic dermatitis
IL-13Rα1 expression on β-cell-specific T cells in NOD mice.
Quinn et al., Toledo, United States. In Diabetes, 2011
The loss of IL-13Ralpha1 on islet-reactive T cells may be a biomarker for fading regional immune regulation and progression to overt diabetes.
mRNA profiles of cytokine receptors in unstimulated peripheral blood mononuclear cells from patients with chronic idiopathic urticaria.
Chen et al., Beijing, China. In J Biomed Res, 2011
The mRNA levels of tumor necrosis factor receptor (TNFR), interferon-γ receptor (IFN-γR), and interleukin-10 receptor (IL-10R) were statistically increased in the CIU group (P < 0.05), while IL-2R, IL-4R, IL-6R, and IL-13R showed no significant differences between the CIU and other groups.
Neonatal immunity: faulty T-helpers and the shortcomings of dendritic cells.
Adkins et al., Columbia, United States. In Trends Immunol, 2009
Together, these circumstances lead to efficient differentiation of Th2 cells and the expression of an IL-4Ralpha/IL-13Ralpha1 heteroreceptor on Th1 cells.
The signaling function of the IL-13Ralpha2 receptor in the development of gastrointestinal fibrosis and cancer surveillance.
Fuss et al., Bethesda, United States. In Curr Mol Med, 2009
The IL-13Ralpha2 receptor is a high affinity receptor for IL-13 that is used only by IL-13 and is quite distinct from the well known IL-13Ralpha1 receptor that IL-13 shares with IL-4.
Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction.
Tavassoli et al., Southampton, United Kingdom. In Biochem Soc Trans, 2009
IL-4 and IL-13 share many functional properties as a result of their utilization of a common receptor complex comprising IL-13Ralpha1 (IL-13 receptor alpha-chain 1) and IL-4Ralpha.
Role of IL-4 and Th2 responses in allograft rejection and tolerance.
Bishop et al., Sydney, Australia. In Curr Opin Organ Transplant, 2009
In addition to its effects on bone marrow-derived cells, IL-4 affects parenchymal cells by signalling through the type II receptor, which consists of the IL-4R alpha chain (IL-4Ralpha) and the IL-13Ralpha1, which also binds IL-13.
Immune pathways for translating viral infection into chronic airway disease.
Patel et al., Saint Louis, United States. In Adv Immunol, 2008
The interaction between iNKT cells and macrophages depends on contact between the semi-invariant Valpha14Jalpha18-TCR on lung iNKT cells and the oligomorphic MHC-like protein CD1d on macrophages as well as NKT cell production of IL-13 that binds to the IL-13 receptor (IL-13R) on the macrophage.
Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system.
Garcia et al., Stanford, United States. In Cell, 2008
Here we present the crystal structures of the complete set of type I (IL-4R alpha/gamma(c)/IL-4) and type II (IL-4R alpha/IL-13R alpha1/IL-4, IL-4R alpha/IL-13R alpha1/IL-13) ternary signaling complexes.
Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain.
Wynn et al., Bethesda, United States. In Nat Immunol, 2008
Il13ra1-/- mice showed less mortality after infection with Schistosoma mansoni and more susceptibility to Nippostrongylus brasiliensis. IL-13Ralpha1 was essential for allergen-induced airway hyperreactivity and mucus hypersecretion.
IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis.
Kitani et al., Bethesda, United States. In Nat Med, 2006
In studies of the mechanisms underlying such induction, we found that IL-13 induces transforming growth factor (TGF)-beta(1) in macrophages through a two-stage process involving, first, the induction of a receptor formerly considered to function only as a decoy receptor, IL-13Ralpha(2).
IL-4 utilizes an alternative receptor to drive apoptosis of Th1 cells and skews neonatal immunity toward Th2.
Zaghouani et al., Columbia, United States. In Immunity, 2004
These Th1 cells were isolated, and their death was correlated with elevated IL-13Ralpha1 chain expression.
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