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Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

Ikaros, IK1
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, AIO, Kir2.1
Papers on Ikaros
Nav1.5 N-Terminal Domain Binding to α1-Syntrophin Increases Membrane Density of Human Kir2.1, Kir2.2 and Nav1.5 Channels.
Delpón et al., Madrid, Spain. In Cardiovasc Res, Feb 2016
Nav1.5 N-terminal domain, by itself (the 132 aa peptide) (Nter), exerts a "chaperone-like" effect that increases sodium (INa) and inward rectifier potassium (IK1) currents by enhancing the expression of Nav1.5, Kir2.1, and Kir2.2 channels as demonstrated in Chinese hamster ovary (CHO) cells and in rat cardiomyocytes.
Ikaros limits follicular B cell activation by deregulating B cell receptor signaling pathways.
Kastner et al., Illkirch-Graffenstaden, France. In Biochem Biophys Res Commun, Feb 2016
UNASSIGNED: The Ikaros transcription factor is essential for early B cell development, but its effect on mature B cells is debated.
Cloning and characterizing of the murine IRF-3 gene promoter region.
Zhou et al., Nanjing, China. In Immunol Res, Feb 2016
This region contains IK1, Egr2, Cmyb, E2F1 and YY1 putative transcription factor binding sites.
The Evolution of Tumors in Mice and Humans with Germline p53 Mutations.
Hainaut et al., Grenoble, France. In Cold Spring Harb Symp Quant Biol, Jan 2016
After that, the T-cell clone selects gene amplifications in cyclin D and cdk-6, and in Ikaros in the Notch pathway.
IK1 channels do not contribute to the slow afterhyperpolarization in pyramidal neurons.
Adelman et al., Portland, United States. In Elife, Dec 2015
The sAHP is due to a Ca(2+)-dependent, voltage-independent K(+) conductance, the molecular identity of which has remained elusive until a recent report suggested the Ca(2+)-activated K(+) channel, IK1 (KCNN4) as the sAHP channel in CA1 pyramidal neurons.
Myeloproliferative neoplasms: Current molecular biology and genetics.
Saeidi, Kermān, Iran. In Crit Rev Oncol Hematol, Dec 2015
Some other genes' location such as TET oncogene family member 2 (TET2), additional sex combs-like 1 (ASXL1), casitas B-lineage lymphoma proto-oncogene (CBL), isocitrate dehydrogenase 1/2 (IDH1/IDH2), IKAROS family zinc finger 1 (IKZF1), DNA methyltransferase 3A (DNMT3A), suppressor of cytokine signaling (SOCS), enhancer of zeste homolog 2 (EZH2), tumor protein p53 (TP53), runt-related transcription factor 1 (RUNX1) and high mobility group AT-hook 2 (HMGA2) have also identified to be involved in MPNs phenotypes.
Pharmacological exploration of the resting membrane potential reserve: Impact on atrial fibrillation.
Jespersen et al., Utrecht, Netherlands. In Eur J Pharmacol, Dec 2015
The atrial resting membrane potential is established following ionic currents through the inwardly rectifying K(+) currents IK1, IK,ACh and IK,Ca and to a lesser extent by other ion channels as well as by exchangers and pumps.
Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B.
Zhou et al., United States. In Gene, Dec 2015
Interestingly, the antitumor effects of immunomodulatory drugs are caused by their binding to the CRL4CRBN complex and re-directing the E3 ligase towards the Ikaros transcription factors IKZF1 and IKZF3.
Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia.
Mullighan et al., Memphis, United States. In Cancer Cell, Oct 2015
Alterations of IKZF1, encoding the lymphoid transcription factor IKAROS, are a hallmark of high-risk acute lymphoblastic leukemia (ALL), however the role of IKZF1 alterations in ALL pathogenesis is poorly understood.
IKAROS: a multifunctional regulator of the polymerase II transcription cycle.
Milot et al., Montréal, Canada. In Trends Genet, Sep 2015
Interestingly, a few lineage-specific transcription factors, including IKAROS, also regulate transcription elongation.
IKZF1 (IKAROS) deletions in B-ALL and its clinical correlation: A prospective study from a tertiary care centre in Northern India.
Kumar et al., New Delhi, India. In Leuk Res, Aug 2015
INTRODUCTION: IKZF1 deletions have been reported with variable frequency in B-ALL.
The chromatin remodeler Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth.
Murre et al., San Diego, United States. In Nat Immunol, Jul 2015
Early B cell development is orchestrated by the combined activities of the transcriptional regulators E2A, EBF1, Foxo1 and Ikaros.
Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.
Thomä et al., Basel, Switzerland. In Nature, 2014
IMiDs target the E3 ubiquitin ligase CUL4-RBX1-DDB1-CRBN (known as CRL4(CRBN)) and promote the ubiquitination of the IKAROS family transcription factors IKZF1 and IKZF3 by CRL4(CRBN).
Stage-specific control of early B cell development by the transcription factor Ikaros.
Busslinger et al., Vienna, Austria. In Nat Immunol, 2014
Here we studied its B cell-specific function by conditional inactivation of the gene encoding Ikaros (Ikzf1) in pro-B cells.
Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia.
Georgopoulos et al., United States. In Nat Immunol, 2014
Deletion of the DNA-binding domain of the transcription factor Ikaros generates dominant-negative isoforms that interfere with its activity and correlate with poor prognosis in human precursor B cell acute lymphoblastic leukemia (B-ALL).
An intermediate-conductance Ca2+-activated K+ channel is important for secretion in pancreatic duct cells.
Novak et al., Copenhagen, Denmark. In Am J Physiol Cell Physiol, 2012
Intermediate potassium (IK) channel KCNN4 may be partially involved in setting the resting membrane potential. Furthermore, the IK channels play a role in anion and potassium transport in stimulated pancreatic ducts.
Expression of dominant-negative Ikaros isoforms and associated genetic alterations in Chinese adult patients with leukemia.
Ge et al., Nanjing, China. In Ann Hematol, 2012
A rationale for the integration of aberrant Ikaros isoforms in the evaluation of adult adult lymphoblastic leukemia (ALL), particularly in Ph(+)ALL patients.
Modafinil inhibits K(Ca)3.1 currents and muscle contraction via a cAMP-dependent mechanism.
Suh et al., Seoul, South Korea. In Pharmacol Res, 2012
Modafinil inhibits K(Ca)3.1 channels and vascular smooth muscle contraction by cAMP-dependent phosphorylation.
Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study.
Willman et al., Albuquerque, United States. In Blood, 2012
In multivariate analyses, NCI risk group, minimal residual disease, high CRLF2 expression, and IKZF1 lesions were associated with relapse-free survival.
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