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Immunoglobulin heavy constant gamma 4

Top mentioned proteins: IgG1, IgG3, ACID, CAN, HAD
Papers on IGHG4
Applied Protein and Molecular Techniques for Characterization of B Cell Neoplasms in Horses.
Felippe et al., Botucatu, Brazil. In Clin Vaccine Immunol, Nov 2015
IGHG1 or IGHG4/7 gene expression was consistent with surface protein expression, and secreted isotype and Ig spectratyping revealed one dominant monoclonal peak.
Recurrent genomic rearrangements in primary testicular lymphoma.
Steidl et al., Vancouver, Canada. In J Pathol, Jun 2015
We report novel CIITA, FOXP1 and PDL rearrangements involving IGHG4, FLJ45248, RFX3, SMARCA2 and SNX29.
Zeolite Nanoparticles for Selective Sorption of Plasma Proteins.
Rezaee et al., Groningen, Netherlands. In Sci Rep, 2014
IGHG1, IGHG2 and IGHG4) proteins.
Chromosomal and genetic imbalances in Chinese patients with rhabdomyosarcoma detected by high-resolution array comparative genomic hybridization.
Li et al., Wuhan, China. In Int J Clin Exp Pathol, 2013
However, frequent losses were detected in IGHG1, IGHM, IGHG3, and IGHG4 (14q32.33),
Human Gm, Km, and Am allotypes and their molecular characterization: a remarkable demonstration of polymorphism.
Lefranc et al., Montpellier, France. In Methods Mol Biol, 2011
Gm-Am allotypes are inherited in fixed combinations, or Gm-Am haplotypes, owing to the linkage of the human IGHC genes (IGHG3, IGHG1, IGHA1, IGHG2, IGHG4, IGHE, and IGHA2 from 5' to 3' in the IGH locus on chromosome 14).
The complete map of the Ig heavy chain constant gene region reveals evidence for seven IgG isotypes and for IgD in the horse.
Antczak et al., Ithaca, United States. In J Immunol, 2004
The newly found IGHG7 gene, which has a high homology to the equine IGHG4 gene, is located between the IGHG3 and IGHG4 genes.
Rhesus macaque antibody molecules: sequences and heterogeneity of alpha and gamma constant regions.
Attanasio et al., Atlanta, United States. In Immunology, 2004
Although it is currently thought that rhesus macaques express three IgG subclasses, we identified four IGHG genes, which were designated IGHG1, IGHG2, IGHG3 and IGHG4 on the basis of sequence similarities with the four human genes encoding the IgG1, IgG2, IgG3 and IgG4 subclasses.
Baboon immunoglobulin constant region heavy chains: identification of four IGHG genes.
Scinicariello et al., Atlanta, United States. In Immunogenetics, 2002
These four genes were designated IGHG1, IGHG2, IGHG3 and IGHG4 on the basis of sequence similarities with the four human genes encoding the IgG1, IgG2, IgG3 and IgG4 subclasses and the three known rhesus macaque IGHG genes.
MUC1 is activated in a B-cell lymphoma by the t(1;14)(q21;q32) translocation and is rearranged and amplified in B-cell lymphoma subsets.
Chaganti et al., New York City, United States. In Blood, 2000
The translocation linked the IGHG4 switch (Sgamma4) sequences of the productively rearranged allele to chromosome 1 sequences downstream of MUC1, leaving the MUC1 transcriptional unit intact.
Characterization of human gamma 4 switch region polymorphisms suggests a meiotic recombinational hot spot within the Ig locus: influence of S region length on IgG4 production.
Hammarström et al., Huddinge, Sweden. In J Immunol, 1998
Human gamma4 gene RFLPs, revealed after BamHI digestion, show IGHG4 alleles of 9.0 (9.2), 9.4, and 9.6 kb at various frequencies in different ethnic populations.
Duplications and deletions of the human IGHC locus: evolutionary implications.
Hammarström et al., Huddinge, Sweden. In Immunogenetics, 1995
The only deletion common to all racial groups is an isolated deletion of the IGHG4 gene.
Multiple levels of analysis of an IGHG4 gene deletion.
Carbonara et al., Torino, Italy. In Hum Genet, 1990
In this paper, we report the characterization of a new type of deletion, involving the IGHG4 gene, in a subject who also carries a larger deletion of a previously described type on the second chromosome.
A human immunoglobulin IGHG3 allele (Gmb0,b1,c3,c5,u) with an IGHG4 converted region and three hinge exons.
Lefranc et al., Montpellier, France. In Immunogenetics, 1988
Moreover, we show that the LAT G3m (b0, b1, c3, c5, u) coding sequence results from the conversion, in the CH3 exon, of the G3m (b0, b1, b3, b4, b5, u, v) allele, the most frequent IGHG3 gene in the Negroid populations, by the homologous region of a IGHG4 gene.
Restriction fragment haplotypes in the human immunoglobulin IGHG locus and their correlation with the Gm polymorphism.
Lefranc et al., Montpellier, France. In Eur J Immunol, 1988
The alleles at these three closely linked loci are transmitted as Gm haplotypes, together with the IGHG4 and the IGHGP (or pseudo gamma) genes.
Definition of the RFLP alleles in the human immunoglobulin IGHG gene locus.
Lefranc et al., Montpellier, France. In Eur J Immunol, 1988
Our data demonstrate that the restriction fragment length polymorphism is occasionally due to the presence or absence of a given restriction site as a consequence of a point mutation, such as the creation of an Eco RI site, at the codon 3 of exon 2 in one IGHG4 allele (IGHG4*D2).
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