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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Insulin-like growth factor 1 receptor

IGF-I receptor, IGF-IR, IGF-1R, IGF-1 receptor, insulin-like growth factor-I receptor, IGF receptor
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Insulin, Insulin-Like Growth Factor I, Akt, CAN, V1a
Papers using IGF-I receptor antibodies
Stable IgG-like bispecific antibodies directed toward the type I Insulin-like growth factor receptor demonstrate enhanced ligand blockade and anti-tumor activity
Han Zhaozhong, In PLoS ONE, 2010
... Additional anti-human IGF-1R antibodies were obtained from Calbiochem for Ab-1 (clone αIR3), Ab-3 (Clone 33255.111),
Serum 3′-sulfo-Lea indication of gastric cancer metastasis.
Campbell Moray, In PLoS ONE, 2008
... ™-2-IGF-3′UTR: The 3′ UTR fragment (3′untranslated region) of IGF-1R (Genbank ACCESSION: NM_000875) containing the binding site ( ...
AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms
Luo Zhijun et al., In Oncogene, 2003
... Antibodies for IGF1R were from Santa Cruz Biotechnology, Inc (Santa Cruz, CA) ...
The emerging role of the insulin-like growth factors in oral biology
Taniguchi Akiyoshi et al., In In Vitro Cellular & Developmental Biology. Animal, 2003
... IGF1R and IGF2R were stained with polyclonal rabbit anti-IGF1R (1:100; EnoGene Biotech, New York, NY) and ...
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Papers on IGF-I receptor
Mastermind-like 3 controls proliferation and differentiation in neuroblastoma.
Bajpe et al., Netherlands. In Mol Cancer Res, Feb 2016
Additionally, MAML3 has RA-independent functions, including the activation of IGF1R and downstream AKT signaling via upregulation of IGF2, resulting in increased proliferation.
Relevance of MicroRNA-18a and MicroRNA-199a-5p to hepatocellular carcinoma recurrence after living donor liver transplantation.
Maehara et al., Fukuoka, Japan. In Liver Transpl, Feb 2016
In HCC cells, miR-18a regulated the expression of tumor necrosis factor alpha induced protein 3 (TNFAIP3), and miR-199a-5p regulated the expression of hypoxia-inducible factor 1 alpha (HIF1A), vascular endothelial growth factor A (VEGFA), insulin-like growth factor 1 receptor (IGF1R), and insulin-like growth factor 2 (IGF2).
Insulin deficiency induces rat renal mesangial cell dysfunction via activation of IGF-1/IGF-1R pathway.
Lu et al., Shanghai, China. In Acta Pharmacol Sin, Feb 2016
The expression of insulin receptor (IR), insulin-like growth factor-1 receptor (IGF-1R), phosphorylated IGF-1R, fibronectin, and collagen IV was determined with Western blot analysis.
IRS-1 Functions as a Molecular Scaffold to Coordinate IGF-I/IGFBP-2 Signaling During Osteoblast Differentiation.
Clemmons et al., Nanjing, China. In J Bone Miner Res, Feb 2016
However RPTPβ inactivation also requires IGF-I receptor activation.
miR-322 regulates insulin signaling pathway and protects against metabolic syndrome-induced cardiac dysfunction in mice.
Lompré et al., Paris, France. In Biochim Biophys Acta, Feb 2016
UNASSIGNED: We identified murine miR-322, orthologous to human miR-424, as a new regulator of insulin receptor, IGF-1 receptor and sirtuin 4 mRNA in vitro and in vivo in the heart and found that miR-322/424 is highly expressed in the heart of mice.
Ewing sarcoma: The clinical relevance of the insulin-like growth factor 1 and the poly-ADP-ribose-polymerase pathway.
Gelderblom et al., Leiden, Netherlands. In Eur J Cancer, Feb 2016
Currently the insulin-like growth factor 1 receptor (IGF-1R) pathway and the poly-ADP(adenosinediphosphate)-ribose-polymerase (PARP) pathway are being investigated for potential targeted therapies.
Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.
López-Otín et al., Oviedo, Spain. In Nat Med, Jan 2016
We demonstrate that AIRAPL interacts with newly synthesized insulin-related growth factor-1 receptor (IGF1R) polypeptides, promoting their ubiquitination and proteasome-mediated degradation.
Pathogenesis of thyroid eye disease: review and update on molecular mechanisms.
Selva et al., Melbourne, Australia. In Br J Ophthalmol, Jan 2016
Orbital fibroblasts express both thyrotropin receptor (TSHR) and insulin-like growth factor-1 receptor (IGF-1R) at higher levels than normal fibroblasts.
Endothelial IGF-1 Receptor Signalling in Diabetes and Insulin Resistance.
Wheatcroft et al., Leeds, United Kingdom. In Trends Endocrinol Metab, Jan 2016
UNASSIGNED: Despite contemporary medical therapy, people with diabetes and insulin resistance experience substantially increased risk of cardiovascular events caused by atherosclerosis.
Potential role of targeted therapies in the treatment of triple-negative breast cancer.
Bishayee et al., Miami, United States. In Anticancer Drugs, Jan 2016
TNBC is commonly characterized by the absence of estrogen, progesterone, and the Her2/neu receptor and is usually diagnosed by immunohistochemistry. Mutations in the BRCA1 gene, as well as overexpression of oncogenic kinases, such as human epidermal growth factor receptor 2, vascular endothelial growth factor-A, insulin-like growth factor-1 (IGF-1)/IGF-1 receptor, and transforming growth factor-β1, have been found to be correlated with a higher risk of metastasis and poor overall survival in TNBC patients.
MECHANISMS IN ENDOCRINOLOGY: Novel genetic causes of short stature.
Kant et al., Leiden, Netherlands. In Eur J Endocrinol, Dec 2015
Heterozygous IGF1R defects are a relatively frequent cause of prenatal and postnatal growth retardation.
Paternally Inherited IGF2 Mutation and Growth Restriction.
Eggermann et al., Tübingen, Germany. In N Engl J Med, Aug 2015
In humans, mutations in IGF1 or IGF1R cause intrauterine and postnatal growth restriction; however, data on mutations in IGF2, encoding insulin-like growth factor (IGF) II, are lacking.
SWOG S0925: A Randomized Phase II Study of Androgen Deprivation Combined With Cixutumumab Versus Androgen Deprivation Alone in Patients With New Metastatic Hormone-Sensitive Prostate Cancer.
Thompson et al., Tacoma, United States. In J Clin Oncol, Jun 2015
PURPOSE: Cixutumumab, formerly IMC-A12, is a recombinant human monoclonal immunoglobulin G1 antibody that targets insulin-like growth factor I receptor (IGF-IR).
Linsitinib (OSI-906) versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: a double-blind, randomised, phase 3 study.
Hammer et al., Würzburg, Germany. In Lancet Oncol, Apr 2015
Linsitinib (OSI-906) is a potent, oral small molecule inhibitor of both IGF-1R and the insulin receptor, which has shown acceptable tolerability and preliminary evidence of anti-tumour activity.
A targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancer.
Domingo-Domenech et al., New York City, United States. In Cancer Cell, Mar 2015
IGF2 in turn activated IGF1R and INSR as well as a downstream polykinase program.
Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation.
Takahashi et al., Tokyo, Japan. In J Biol Chem, 2012
PI3K activity bound to IGF-IR, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation.
Serine phosphorylation of the insulin-like growth factor I (IGF-1) receptor C-terminal tail restrains kinase activity and cell growth.
O'Connor et al., Cork, Ireland. In J Biol Chem, 2012
SFYYS motif controls the organization of the IGF-1R C terminus relative to the kinase domain. Its phosphorylation by GSK-3beta restrains kinase activity and regulates receptor trafficking and signaling.
Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegeneration.
Liao et al., Memphis, United States. In J Neurosci, 2012
study demonistrated that the first time that zinc can induce IGF-1Rbeta protein degradation in neurons via NEDD4-mediated ubiquitination and the subsequent UPS mechanism.
The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r.
Reik et al., Cambridge, United Kingdom. In Nat Cell Biol, 2012
The controlled release of miR-675 from H19 may also allow rapid inhibition of placental cell proliferation in response to cellular stress or oncogenic signals.
Igf1r is not required for AIB1-induced mammary hyperplasia and ductal branching.
Font de Mora et al., Valencia, Spain. In Front Biosci (elite Ed), 2011
results confirm the essential role of Igf1r in mammary gland morphogenesis and demonstrate that overexpression of AIB1 circumvents the requirement for the Igf1r pathway in promoting epithelial growth during mammary development
More papers using IGF-I receptor antibodies
Insulin-like growth factor binding protein-1 (IGFBP-1) inhibits breast cancer cell motility
Yee Douglas et al., In Oncogene, 2001
... The antibody against the β-subunit of IGF1R (IGF1Rβ) was from Santa Cruz Biotechnology, Inc ...
A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor.
Lee Leo T.O., In PLoS ONE, 2001
... MAP kinase (T202/Y204) (# 9101) antibody, p44/42 MAPK (# 9102) antibody, phospho-Tyr1135/1136 IGF-IR antibody (19H7), IGF-IR antibody (111A9), were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
A new mathematical model for relative quantification in real-time RT-PCR
Schumacher Björn et al., In Nature cell biology, 2000
... IGF-1 receptor regulates lifespan and resistance to oxidative ...
Phosphorylation and regulation of Raf by Akt (protein kinase B)
Kholodenko Boris N et al., In Molecular Systems Biology, 1998
... Rabbit anti-phospho-MEK (S217/S221, anti-phospho-Shc (Y317), anti-IGF-1 receptor β (all from Cell Signaling)), anti-phospho-IR β (Y1162/1163), anti-GRB2 ...
Evidence for glucose/hexosamine in vivo regulation of insulin/IGF-I hybrid receptor assembly
Kearney Mark T. et al., In Diabetes, 1998
... IGF-1 receptor regulates lifespan and resistance to oxidative ...
Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by β1 integrins
Languino Lucia R. et al., In The Journal of Cell Biology, 1997
... HA (American Type Culture Collection); 1C10 to vascular endothelial surface protein (Life Technologies); α-IR3 to IGF-IR (Oncogene); PY20 to phosphotyrosine (Santa Cruz Biotechnology, Inc.); rat mAb to ...
Mechano-transduction in Osteoblastic Cells Involves Strain-regulated Estrogen Receptor α-mediated Control of Insulin-like Growth Factor (IGF) I Receptor Sensitivity to Ambient IGF, Leading to Phosphatidylinositol 3-Kinase/AKT-dependent Wnt/LRP5 Receptor-independent Activation of β-Catenin Signaling*
Price Joanna S. et al., In The Journal of Biological Chemistry, 1995
... phospho-AKT (4060), total AKT (9272), anti-Ser-9 phospho-GSK-3β antibody (9336), anti-GSK-3β (9315), and anti-phospho- and total IGF-IR (3021 and 3027) primary antibodies were obtained from Cell Signaling Technologies (Hitchin, UK) ...
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