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Interleukin 28 receptor, alpha

IFN-lambdaR1, IL-28Ralpha, LICR-2, IL28RA, IL-28R
The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-29, IL-10R2, IL-28A, HAD, IL-10
Papers on IFN-lambdaR1
IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production.
Udalova et al., Oxford, United Kingdom. In J Exp Med, Jul 2015
We identify neutrophils as cells expressing high levels of IFN-λ receptor 1 (IFNLR1)-IL-28 receptor α (IL28RA) and targeted by IL-28A.
NK cells require IL-28R for optimal in vivo activity.
Smyth et al., Australia. In Proc Natl Acad Sci U S A, Jun 2015
IL-28R-deficient mice were resistant to LPS and cecal ligation puncture-induced septic shock, and hallmark cytokines in these disease models were dysregulated in the absence of IL-28R.
Interferon-λ-related genes and therapeutic response in Chinese hepatitis C patients.
Su et al., Nanjing, China. In World J Gastroenterol, May 2015
AIM: To determine the association between rapid viral response and IL28B, IL28RA, IL10RB and MxA polymorphisms in the Chinese Han population.
Association analysis of GWAS and candidate gene loci in a Pakistani population with psoriasis.
Naluai et al., Islamabad, Pakistan. In Mol Immunol, Mar 2015
Overall, only nine SNPs out of the 42 GWAS loci, displayed an odds ratio in the opposite allelic direction and only three did not reach similar odds ratio within 95% confidence interval as previously reported (SLC45A1/TNFRSF9, ELMO1 and IL28RA).
IL-28B is a key regulator of B- and T-cell vaccine responses against influenza.
Kumar et al., Basel, Switzerland. In Plos Pathog, 2014
Since IL-28B inhibited B-cell responses, we designed antagonistic peptides to block the IL-28 receptor α-subunit (IL28RA).
The Role of Interferon-λ Locus Polymorphisms in Hepatitis C and Other Infectious Diseases.
Haas et al., Edinburgh, United Kingdom. In J Innate Immun, 2014
Whilst IFN-λ shares many features with type I IFN induction and signalling pathways, the tissue-specific restricted expression of its receptor, IL28RA, makes IFN-λ a major mediator of host innate immunity in tissues and organs with a high epithelial cell content.
Impairment of type I but not type III IFN signaling by hepatitis C virus infection influences antiviral responses in primary human hepatocytes.
McPhee et al., Bristol, United States. In Plos One, 2014
HCV infection resulted in rapid down-regulation of the type I IFN-α receptor subunit 1 (IFNAR1) transcript in hepatocytes while the transcriptional level of the unique IFN-λ receptor subunit IL28RA was transiently increased.
Association of polymorphism within the interleukin-28 receptor alpha gene, but not in interleukin-28B, with lower urinary tract symptoms (LUTS) in Chinese.
Wei et al., Kunming, China. In Genet Mol Res, 2014
The aim of this study was to determine the relationship between polymorphisms in the IL-28B and IL-28R genes and lower urinary tract symptoms (LUTS) in Chinese patients.
[The function and application of the IL28B gene in HCV infection and treatment].
Xia et al., Kunming, China. In Yi Chuan, 2013
IFN-lambda3 interacts with its acceptor, a heterodimer (IFN-lambdaR1 x IL-10R2), and upregulates the IFN-stimulated gene factors (ISGF).
The genetics of psoriasis and psoriatic arthritis.
Chandran, Toronto, Canada. In Clin Rev Allergy Immunol, 2013
The susceptibility genes identified include HLA-C, IL13, IL4, TNFAIP3, IL23A, IL23R, IL28RA, REL, IFIH1, ERAP, TRAF3IP2, NFKBIA, TYK2, ZNF313, NOS2, FBXL19 and NFKBIA in subjects of European ethnicity and HLA-C, IL12B, LCE3D, ERAP1, TNIP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A in subjects of Chinese ethnicity.
Novel type III interferons produce anti-tumor effects through multiple functions.
Tagawa et al., Chiba, Japan. In Front Biosci, 2012
The receptor complex of IFN-lambdas is composed of the IL-10 receptor beta (IL-10Rbeta) and a novel IL-28 receptor alpha (IL-28Ralpha).
Analysis of the IL28RA locus as genetic risk factor for multiple sclerosis.
Vandenbroeck et al., Leioa, Spain. In J Neuroimmunol, 2012
No consistent association is found between IL28RA and multiple sclerosis in a Basque-Spanish population.
Genetic variation in IL28RA is associated with the outcomes of HCV infection in a high-risk Chinese population.
Yu et al., Nanjing, China. In Infect Genet Evol, 2011
two SNPs in IL28RA are correlated with susceptibility to HCV infection and spontaneous viral clearance, which implicates a primary role of IL28RA in the outcomes of HCV infection
Suicidal ideation during antidepressant treatment: do genetic predictors exist?
Perroud, Genève, Switzerland. In Cns Drugs, 2011
In this perspective, several genetic predictors have been highlighted, the majority of which relate to common mechanisms of antidepressant action: genes involved in the neurotrophic and synaptic plasticity systems (CREB1, and BDNF and its receptor NTRK2), noradrenergic system (ADRA2A), glutamatergic system (GRIA3, GRIK2 and GDA), inflammatory and hypothalamic-pituitary-adrenal (HPA) axis systems (IL28RA and FKBP5) and in other brain functions (PAPLN, APOO, KCNIP4 and ELP3).
Crystal structure of human interferon-λ1 in complex with its high-affinity receptor interferon-λR1.
Wlodawer et al., Frederick, United States. In J Mol Biol, 2011
IFN-lambdaR1 consists of two distinct domains having fibronectin type III topology.
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
Trembath et al., Oxford, United Kingdom. In Nat Genet, 2010
Seven loci harbored genes with recognized immune functions (IL28RA, REL, IFIH1, ERAP1, TRAF3IP2, NFKBIA and TYK2).
Purification, crystallization and preliminary crystallographic studies of the complex of interferon-lambda1 with its receptor.
Zdanov et al., Frederick, United States. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010
Although the IFN-lambda1(Bac)-IFN-lambda1R1 and IFN-lambda1(Ins)-IFN-lambda1R1 complexes differed only in the nature of the expression system used for the ligand, their crystallization conditions and crystal forms were quite different
Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines.
Wolk et al., Berlin, Germany. In Genes Immun, 2009
study supports that IFN-lambdas do not influence every type of cell and that membrane-associated variant IFN-lambda R1 expression is not sufficient to ensure cellular sensitivity toward these cytokines.
IL-28, IL-29 and their class II cytokine receptor IL-28R.
Klucher et al., Seattle, United States. In Nat Immunol, 2003
IL-28 and IL-29 interact with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan class II receptor chain, designated IL-28Ralpha.
IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.
Donnelly et al., Newark, United States. In Nat Immunol, 2003
distinct receptor complex that is utilized by all three IFN-lambda proteins for signaling and is composed of two subunits, a receptor designated CRF2-12 (also designated as IFN-lambdaR1) and a second subunit, CRF2-4 (also known as IL-10R2)
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