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Interferon, kappa

IFN-kappa, IFNK, Interferon-kappa
This gene encodes a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Interferon-beta, CAN, IFN-gamma, TP1, IL-10
Papers on IFN-kappa
Capturing the biological impact of CDKN2A and MC1R genes as an early predisposing event in melanoma and non melanoma skin cancer.
Puig et al., Barcelona, Spain. In Oncotarget, 2014
As a result, we found that 1535 transcripts were deregulated in CDKN2A mutated cells, with over-expression of immunity-related genes (HLA-DPB1, CLEC2B, IFI44, IFI44L, IFI27, IFIT1, IFIT2, SP110 and IFNK) and down-regulation of genes playing a role in the Notch signaling pathway.
Molecular and functional characterization of canine interferon-epsilon.
Liu et al., Beijing, China. In J Interferon Cytokine Res, 2013
Canine IFN-ε (IFNE), IFN-κ (IFNK), and IFN-λ (IFNL) were discovered for the first time.
Single nucleotide polymorphisms within interferon signaling pathway genes are associated with colorectal cancer susceptibility and survival.
Försti et al., Heidelberg, Germany. In Plos One, 2013
Seven SNPs in IFNA1, IFNA13, IFNA21, IFNK, IFNAR1 and IFNGR1 were associated with CRC risk.
A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of urinary symptoms after radiotherapy for prostate cancer.
Rosenstein et al., New York City, United States. In J Urol, 2013
These single nucleotide polymorphisms form a haplotype block that encompasses the inflammation signaling gene IFNK.
Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon α-kinoid.
Houssiau et al., Brussels, Belgium. In Arthritis Rheum, 2013
OBJECTIVE: We developed interferon-α-kinoid (IFN-K), a drug composed of inactivated IFNα coupled to a carrier protein, keyhole limpet hemocyanin.
High-risk human papillomaviruses repress constitutive kappa interferon transcription via E6 to prevent pathogen recognition receptor and antiviral-gene expression.
Stubenrauch et al., Tübingen, Germany. In J Virol, 2011
The viral E6 and E7 oncogenes are sufficient for interferon-kappa repression, with E6 being mainly responsible.
Active immunisation of human interferon α transgenic mice with a human interferon α Kinoid induces antibodies that neutralise interferon α in sera from patients with systemic lupus erythematosus.
Grouard-Vogel et al., Paris, France. In Ann Rheum Dis, 2011
In the current study, the ability of active immunisation with a human (hu) IFNα2b Kinoid (IFN-K) to break B cell tolerance to IFNα and to induce huIFNα-neutralising antibodies in mice immunotolerant to huIFNα2b was assessed.
IFN-κ, a novel type I IFN, is undetectable in HPV-positive human cervical keratinocytes.
Zehbe et al., Thunder Bay, Canada. In Lab Invest, 2010
IFN-kappa is down-regulated in cervical keratinocytes harboring HPV, which may be a contributing factor in the progression of a cervical lesion
Differential expression and activity of the porcine type I interferon family.
Blecha et al., Manhattan, United States. In Physiol Genomics, 2010
These functional IFN genes are classified into 17 IFN-alpha subtypes, 11 IFN-delta subtypes, 7 IFN-omega subtypes, and single-subtype subclasses of IFN-alphaomega, IFN-beta, IFN-epsilon, and IFN-kappa.
The role of genetic variation near interferon-kappa in systemic lupus erythematosus.
James et al., Cincinnati, United States. In J Biomed Biotechnol, 2009
Studied IFNK single nucleotide polymorphisms in 3982 Systemic lupus erythematosus cases and 4275 controls.
Chiropteran types I and II interferon genes inferred from genome sequencing traces by a statistical gene-family assembler.
Ramsburg et al., Durham, United States. In Bmc Genomics, 2009
We confirmed our inferences by direct cloning and sequencing of IFNA, IFNB, IFND, and IFNK in P. vampyrus, and by demonstrating transcription of some of the inferred genes by known interferon-inducing stimuli.
Epigenetic silencing of interferon-kappa in human papillomavirus type 16-positive cells.
Rösl et al., Heidelberg, Germany. In Cancer Res, 2009
This is the first report showing an epigenetic silencing of type I IFN after HPV16 oncogene expression
Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.
Gregersen et al., Cambridge, United States. In Mol Med, 2008
Multiple single nucleotide polymorphism (SNP) markers showed significant associations near or within loci including: the v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB) gene on chromosome 20; the type I interferon gene IFNk on chromosome 9; and in a locus on chromosome 7 that includes the paraoxonase I (PON1) gene.
Interferons, interferon-like cytokines, and their receptors.
Walter et al., United States. In Immunol Rev, 2004
All the known IFNs and IFN-like cytokines are described [IFN-alpha, IFN-beta, IFN-epsilon, IFN-kappa, IFN-omega, IFN-delta, IFN-tau, IFN-gamma, limitin, interleukin-28A (IL-28A), IL-28B, and IL-29] as well as their receptors and signal transduction pathways.
The Class II cytokine receptor (CRF2) family: overview and patterns of receptor-ligand interactions.
Kotenko et al., United States. In Cytokine Growth Factor Rev, 2004
These cytokines include: a new human Type I IFN, IFN-kappa; molecules related to IL-10 (IL-19, IL-20, IL-22, IL-24, IL-26); and IFN-lambdas (IL-28/29), which have antiviral and cell stimulatory activities reminiscent of Type I IFNs, but act through a distinct receptor.
Expression of a novel murine type I IFN in the pancreatic islets induces diabetes in mice.
Lira et al., United States. In J Immunol, 2003
Mouse IFN-kappa is expressed at low levels in peritoneal macrophages, its expression up-regulated by double-stranded RNA and IFN-gamma; transgenic mice overexpressing murine IFN-kappa in the pancreatic islets develop overt diabetes with hyperglycemia.
The human interferon system: characterization and classification after discovery of novel members.
Kontseková et al., Bratislava, Slovakia. In Acta Virol, 2002
However, in the last three years, the discovery and characterization of IFNs including IFN-epsilon (IFN-epsilon), IFN-kappa (IFN-kappa) and a novel IFN-lambda (IFN-lambda) family, in particular, substantially changed this opinion.
Review: IFN-alpha/beta receptor interactions to biologic outcomes: understanding the circuitry.
Fish et al., Toronto, Canada. In J Interferon Cytokine Res, 2002
Type I interferons (IFNs), which include the IFN-alphas, IFN-beta, IFN-omega, IFN-kappa, and IFN-tau, are an evolutionarily conserved group of secreted cytokines that serve as potent extracellular mediators of host defense and homeostasis.
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