gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Interferon, gamma-inducible protein 16

This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011] (from NCBI)
Top mentioned proteins: 18 U, AIM2, CAN, ACID, V1a
Papers on IFI16
Anti-IFI16 antibodies in scleroderma are associated with digital gangrene.
Casciola-Rosen et al., Baltimore, United States. In Arthritis Rheumatol, Jan 2016
OBJECTIVE: Our aim was to examine the association between anti-interferon inducible protein 16 (IFI16) antibodies and clinical features of scleroderma.
[Effect of Astragalus mongholicus polysaccharides on gene expression profiles of dendritic cells isolated from healthy donors].
Li et al., Guangzhou, China. In Nan Fang Yi Ke Da Xue Xue Bao, Jan 2016
and down-regulated expression of expression of IFI16 (0.98∓0.18 vs 0.46∓0.11).
The innate immune sensor IFI16 recognizes foreign DNA in the nucleus by scanning along the duplex.
Sohn et al., Groningen, Netherlands. In Elife, Jan 2016
By combining biochemical assays and single-molecule techniques, we show that the nuclear innate immune sensor IFI16 one-dimensionally tracks long stretches of exposed foreign dsDNA to assemble into supramolecular signaling platforms.
Epigenetic regulation of ZEB1-RAB25/ESRP1 axis plays a critical role in phenylbutyrate treatment-resistant breast cancer.
Watanabe et al., Japan. In Oncotarget, Jan 2016
CRL and MDAMB453 cells were identified as PB-sensitive, while MDAMB231 cells were PB-resistant.RAB25 and ESRP1 were identified as key regulators of PB sensitivity, while ANKD1, ETS1, PTRF, IFI16 and KIAA1199 acted as PB resistance-related genes.
APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease.
Arcos-Burgos et al., Canberra, Australia. In Mol Psychiatry, Jan 2016
Exploratory linear mixed-effects multilocus analysis suggested that other functional variants harbored in genes involved in cell proliferation, protein degradation, apoptotic and immune dysregulation processes (i.e., GPR20, TRIM22, FCRL5, AOAH, PINLYP, IFI16, RC3H1 and DFNA5) might interact with the APOE*E2 allele.
The Emerging Role of Nuclear Viral DNA Sensors.
Cristea et al., Princeton, United States. In J Biol Chem, Nov 2015
The interferon-inducible protein IFI16 was shown to bind nuclear viral DNA and initiate immune signaling, culminating in antiviral cytokine secretion.
The nucleic acid-sensing inflammasomes.
Xiao, Cleveland, United States. In Immunol Rev, May 2015
Structural and biophysical studies have shed light on the mechanisms of nucleic acid recognition and signaling complex assembly involving the AIM2 (absent in myeloma 2) and IFI16 (γ-interferon-inducible protein 16) inflammasomes.
Innate immune recognition of DNA: A recent history.
Bowie et al., Dublin, Ireland. In Virology, May 2015
Here we review the discoveries that led to an appreciation of the existence of cytosolic DNA sensor proteins, and discuss two key such sensors, cGAS and IFI16, in detail.
Nuclear sensing of viral DNA, epigenetic regulation of herpes simplex virus infection, and innate immunity.
Knipe, Boston, United States. In Virology, May 2015
IFI16 and cGAS are both essential for innate sensing of HSV DNA, and new evidence shows how they work together to initiate innate signaling.
The hierarchical structural architecture of inflammasomes, supramolecular inflammatory machines.
Wu et al., Boston, United States. In Curr Opin Struct Biol, Apr 2015
In particular, these include a crystal structure of the CARD-containing NOD-like receptor NLRC4, the crystallographic and electron microscopy (EM) studies of the dsDNA sensors AIM2 and IFI16, and of the regulatory protein p202, and the cryo-EM filament structure of the PYD domain of the inflammasome adapter ASC.
USP18 downregulation in peripheral blood mononuclear cells predicts nonresponse to interferon-based triple therapy in patients with chronic hepatitis C, genotype 1: a pilot study.
Sperl et al., Praha, Czech Republic. In Ther Clin Risk Manag, 2014
PATIENTS AND METHODS: Expression of IFNG, IFNLR1, and interferon-sensitive genes CXCL9, IFI16, IFI27, ISG15, and USP18 in peripheral blood mononuclear cells was assessed before and during the initial 12 weeks of treatment.
IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV.
Greene et al., San Francisco, United States. In Science, 2014
Using unbiased proteomic and targeted biochemical approaches, as well as two independent methods of lentiviral short hairpin RNA-mediated gene knockdown in primary CD4 T cells, we identify interferon-γ-inducible protein 16 (IFI16) as a host DNA sensor required for CD4 T cell death due to abortive HIV infection.
Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16.
Cristea et al., Princeton, United States. In Proc Natl Acad Sci U S A, 2012
studies establish acetylation as a molecular toggle of IFI16 distribution, providing a simple and elegant mechanism by which this versatile sensor detects pathogenic DNA in a localization-dependent manner
Preferential binding of IFI16 protein to cruciform structure and superhelical DNA.
Arrowsmith et al., Brno, Czech Republic. In Biochem Biophys Res Commun, 2012
this novel DNA-binding property of IFI16 protein to scDNA and cruciform structures may play critical roles in its tumor suppressor function.
Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.
Xiao et al., Bethesda, United States. In Immunity, 2012
crystal structures of AIM2 and IFI16 HIN domains in complex with double-stranded (ds) DNA
Overexpression of the DNA sensor proteins, absent in melanoma 2 and interferon-inducible 16, contributes to tumorigenesis of oral squamous cell carcinoma with p53 inactivation.
Morishita et al., Miyazaki, Japan. In Cancer Sci, 2012
expression of AIM2 and IFI16 may have oncogenic activities in the OSCC cells that have inactivated the p53 system.
The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication.
Landolfo et al., Torino, Italy. In Plos Pathog, 2012
data implicate IFI16 as a novel restriction factor against HCMV replication and provide new insight into the physiological functions of the IFN-inducible gene IFI16 as a viral restriction factor.
Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.
Golenbock et al., Worcester, United States. In Immunity, 2011
Parasite DNA, parasitized erythrocytes and oligonucleotides containing the AT-rich motif induce type I IFNs via a pathway that did not involve the previously described sensors TLR9, DAI, RNA polymerase-III or IFI16/p204.
IFI16 is an innate immune sensor for intracellular DNA.
Bowie et al., Dublin, Ireland. In Nat Immunol, 2010
IFI16, a PYHIN protein, as an intracellular DNA sensor that mediates the induction of interferon-beta
share on facebooktweetadd +1mail to friends