Papers on
IFI16
APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease.Arcos-Burgos et al., Canberra, Australia. In Mol Psychiatry, Jan 2016
Exploratory linear mixed-effects multilocus analysis suggested that other functional variants harbored in genes involved in cell proliferation, protein degradation, apoptotic and immune dysregulation processes (i.e., GPR20, TRIM22, FCRL5, AOAH, PINLYP, IFI16, RC3H1 and DFNA5) might interact with the APOE*E2 allele.
The Emerging Role of Nuclear Viral DNA Sensors.Cristea et al., Princeton, United States. In J Biol Chem, Nov 2015
The interferon-inducible protein IFI16 was shown to bind nuclear viral DNA and initiate immune signaling, culminating in antiviral cytokine secretion.
The nucleic acid-sensing inflammasomes.Xiao, Cleveland, United States. In Immunol Rev, May 2015
Structural and biophysical studies have shed light on the mechanisms of nucleic acid recognition and signaling complex assembly involving the AIM2 (absent in myeloma 2) and IFI16 (γ-interferon-inducible protein 16) inflammasomes.
Innate immune recognition of DNA: A recent history.Bowie et al., Dublin, Ireland. In Virology, May 2015
Here we review the discoveries that led to an appreciation of the existence of cytosolic DNA sensor proteins, and discuss two key such sensors, cGAS and IFI16, in detail.
USP18 downregulation in peripheral blood mononuclear cells predicts nonresponse to interferon-based triple therapy in patients with chronic hepatitis C, genotype 1: a pilot study.Sperl et al., Praha, Czech Republic. In Ther Clin Risk Manag, 2014
PATIENTS AND METHODS: Expression of IFNG, IFNLR1, and interferon-sensitive genes CXCL9, IFI16, IFI27, ISG15, and USP18 in peripheral blood mononuclear cells was assessed before and during the initial 12 weeks of treatment.
IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV.Greene et al., San Francisco, United States. In Science, 2014
Using unbiased proteomic and targeted biochemical approaches, as well as two independent methods of lentiviral short hairpin RNA-mediated gene knockdown in primary CD4 T cells, we identify interferon-γ-inducible protein 16 (IFI16) as a host DNA sensor required for CD4 T cell death due to abortive HIV infection.