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ATPase inhibitory factor 1

inhibits ATP hydrolysis catalyzed by the mitochondrial ATP synthase/ATPase complex [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ATPase, IF2, CAN, ACID, STEP
Papers on IF1
The Inhibitory Mechanism of the ζ Subunit of the F1FO-ATPase Nanomotor of Paracoccus denitrificans and Related α-Proteobacteria.
Mendoza-Hernández et al., Mexico. In J Biol Chem, Feb 2016
It is different from the bacterial (ϵ) and mitochondrial (IF1) inhibitors.
A comparison of statistical approaches used for the optimization of soluble protein expression in Escherichia coli.
Kontopidis et al., Kardítsa, Greece. In Protein Expr Purif, Jan 2016
Subsequently, we slightly modified a published incomplete factorial approach (called IF1) in order to evaluate three expression variables (bacterial strain, induction temperature and culture media) on soluble expression levels of the three tested proteins.
Mitochondrial Inhibitory Factor Protein 1 Functions as an Endogenous Inhibitor for Coupling Factor 6.
Okumura et al., Hirosaki, Japan. In J Cell Biochem, Jan 2016
Inhibitory peptide 1 (IF1) inhibits a unidirectional counter-clockwise rotation of F1 Fo complex without affecting ATP synthesis by a clockwise rotation.
Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic state.
Cuezva et al., Madrid, Spain. In Oncotarget, Dec 2015
UNASSIGNED: The ATPase Inhibitory Factor 1 (IF1) is an inhibitor of the mitochondrial H+-ATP synthase that regulates the activity of both oxidative phosphorylation (OXPHOS) and cell death.
Initiation of mRNA translation in bacteria: structural and dynamic aspects.
Pon et al., Italy. In Cell Mol Life Sci, Nov 2015
The process begins with the formation of an unstable 30S pre-initiation complex (30S pre-IC) containing initiation factors (IFs) IF1, IF2 and IF3, the translation initiation region of an mRNA and initiator fMet-tRNA whose codon and anticodon pair in the P-site following a first-order rearrangement of the 30S pre-IC produces a locked 30S initiation complex (30SIC); this is docked by the 50S subunit to form a 70S complex that, following several conformational changes, positional readjustments of its ligands and ejection of the IFs, becomes a 70S initiation complex productive in initiation dipeptide formation.
Linking structural features from mitochondrial and bacterial F-type ATP synthases to their distinct mechanisms of ATPase inhibition.
Krah, Kyoto, Japan. In Prog Biophys Mol Biol, Oct 2015
Here I discuss the distinct ATPase inhibition mechanism in mitochondrial (IF1) and bacterial (subunits ε and ζ) F-type ATP synthases, based on available structural, biophysical and biochemical data.
ATPase inhibitory factor 1 is a potential prognostic marker for the migration and invasion of glioma.
Wang et al., Zhengzhou, China. In Oncol Lett, Oct 2015
UNASSIGNED: Adenosine triphosphatase inhibitory factor 1 (IF1) has previously been considered to be a driving oncogene in human cancers.
Ecto-F1-ATPase/P2Y pathways in metabolic and vascular functions of high density lipoproteins.
Lichtenstein et al., Toulouse, France. In Atherosclerosis, 2015
The clinical relevance of this F1-ATPase/P2Ys axis in humans has recently been supported by the identification of serum F1-ATPase inhibitor (IF1) as an independent determinant of HDL-Cholesterol (HDL-C) and coronary heart disease risk.
Type 2 Transglutaminase, mitochondria and Huntington's disease: menage a trois.
Campanella et al., Roma, Italy. In Mitochondrion, 2014
Besides reviewing the latest evidences we share also the novel ones on the IF1 pathway depicting a molecular conduit governing mitochondrial turnover and homeostasis relevant to envisaging preventive and therapeutic strategies to respectively predict and counteract deficiencies associated with deregulated mitochondrial function in neuropathology.
[Research on relevance between mitochondrial ATP synthase and malignant tumor].
Zhang et al., In Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2014
Its mechanisms are related to post-transcriptional regulation of the ATP synthase, the hypermethylation of the ATP synthase gene and the inhibitor peptide of the mitochondrial ATP synthase, called ATP synthase inhibitory factor 1 (IF1).
Hypoxia-inducible factor 1α regulates the expression of the mitochondrial ATPase inhibitor protein (IF1) in rat liver.
Yang et al., Kao-hsiung, Taiwan. In Shock, 2011
Hypoxia-inducible factor 1alpha regulates the expression of the mitochondrial ATPase inhibitor protein (IF1) in rat liver.
Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation.
Lin et al., New Haven, United States. In Nat Genet, 2011
Here using a Drosophila eye-outgrowth assay sensitized by the dominant Kr(irregular facets-1)(Kr(If-1)) allele, we show that the Piwi-interacting RNA (piRNA) pathway, but not the short interfering RNA or micro RNA pathway, is involved in canalization.
Up-regulation of the ATPase inhibitory factor 1 (IF1) of the mitochondrial H+-ATP synthase in human tumors mediates the metabolic shift of cancer cells to a Warburg phenotype.
Cuezva et al., Madrid, Spain. In J Biol Chem, 2010
Findings support that the mitochondrial content of IF1 controls the activity of oxidative phosphorylation mediating the shift of cancer cells to an enhanced aerobic glycolysis.
The ectopic F(O)F(1) ATP synthase of rat liver is modulated in acute cholestasis by the inhibitor protein IF1.
Lippe et al., Udine, Italy. In J Bioenerg Biomembr, 2010
The ectopic F(O)F(1) ATP synthase of rat liver is modulated in acute cholestasis by the inhibitor protein IF1.
IEX-1 targets mitochondrial F1Fo-ATPase inhibitor for degradation.
Wu et al., Boston, United States. In Cell Death Differ, 2009
The study reveals that IEX-1 targets the mitochondrial F1Fo-ATPase Inhibitor (IF1) for degradation, resulting in acceleration of ATP hydrolysis, concomitant with reduction in ROS production.
Delta protein kinase C interacts with the d subunit of the F1F0 ATPase in neonatal cardiac myocytes exposed to hypoxia or phorbol ester. Implications for F1F0 ATPase regulation.
Johnson et al., Augusta, United States. In J Biol Chem, 2008
analysis of a novel regulation of the F(1)F(0) ATPase by the delta protein kinase C isozyme
Structure of the 30S translation initiation complex.
Klaholz et al., Illkirch-Graffenstaden, France. In Nature, 2008
In bacteria, the correct messenger RNA start site and the reading frame are selected when, with the help of initiation factors IF1, IF2 and IF3, the initiation codon is decoded in the peptidyl site of the 30S ribosomal subunit by the fMet-tRNA(fMet) anticodon.
Regulation of mitochondrial structure and function by the F1Fo-ATPase inhibitor protein, IF1.
Duchen et al., London, United Kingdom. In Cell Metab, 2008
IF(1) regulates mitochondrial function and structure under both physiological and pathological conditions
The cryo-EM structure of a translation initiation complex from Escherichia coli.
Frank et al., Albany, United States. In Cell, 2005
Additionally, we present evidence for the localization of IF1, IF3, one C-terminal domain of L7/L12, and the N-terminal domain of IF2 in the initiation complex.
Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution.
Ruden et al., Philadelphia, United States. In Nat Genet, 2003
Using a sensitized isogenic D. melanogaster strain, iso-Kr(If-1), we confirm this finding and present evidence supporting an epigenetic mechanism for Hsp90's capacitor function, whereby reduced activity of Hsp90 induces a heritably altered chromatin state.
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