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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Chromosome 1 open reading frame 38

icb-1, C1orf38
Top mentioned proteins: DISP1, CAN, Tec, ACID, BR-3
Papers on icb-1
Inhibition of placental growth factor in renal cell carcinoma.
Teh et al., Singapore, Singapore. In Anticancer Res, 2015
Gene expression profiling resulted in over-expression of the C1orf38 gene, which induced immunoreactivity in macrophages.
Icb-1 gene polymorphism rs1467465 is associated with susceptibility to ovarian cancer.
Treeck et al., Regensburg, Germany. In J Ovarian Res, 2013
In this study, we tested the hypothesis that single nucleotide polymorphisms (SNPs) of differentiation-associated human gene icb-1 (C1orf38) may be associated with ovarian cancer susceptibility.
An extended pyrrolobenzodiazepine-polyamide conjugate with selectivity for a DNA sequence containing the ICB2 transcription factor binding site.
Thurston et al., Paisley, United Kingdom. In J Med Chem, 2013
The DNA-binding affinity and sequence selectivity of each compound were evaluated in DNA thermal denaturation and DNase I footprinting assays, and the ability to inhibit binding of NF-Y to ICB1 and ICB2 was studied using an electrophoretic mobility shift assay (EMSA).
icb-1 Gene counteracts growth of ovarian cancer cell lines.
Ortmann et al., Regensburg, Germany. In Cancer Lett, 2013
Human gene icb-1 has been originally identified to be involved in differentiation processes of cancer cells.
Network analysis of icb-1 gene function in human breast cancer cells.
Ortmann et al., Regensburg, Germany. In J Cell Biochem, 2012
Data of this study suggest that icb-1 might exert a tumor-suppressor function in breast cancer and that its loss might confer relative resistance of breast cancer cells to apoptotic drugs.
Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.
Love et al., Bethesda, United States. In J Immunol, 2012
Themis2 and Themis1 exhibit the same potential to restore T cell development and T cell receptor-mediated signaling in Themis1-deficient mice.
Silencing of the icb-1 gene inhibits the induction of differentiation-associated genes by vitamin D3 and all-trans retinoic acid in gynecological cancer cells.
Treeck et al., Regensburg, Germany. In Int J Mol Med, 2011
These findings together with the observed co-expression of icb-1 with E-cadherin in breast cancer samples support an important role of the icb-1 gene in cancer cell differentiation.
Icb-1 Gene expression is elevated in human endometrial adenocarcinoma and is closely associated with HER2 expression.
Treeck et al., Regensburg, Germany. In Cancer Invest, 2010
Data show that a highly significant positive correlation of icb-1 transcript levels with c-erbB2 (HER2) expression (p <.0001).
Knockdown of ICB-1 gene enhanced estrogen responsiveness of ovarian and breast cancer cells.
Treeck et al., Regensburg, Germany. In Endocr Relat Cancer, 2010
Identification of ICB-1 as a new player in endocrine-related cancer.
Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production.
Wait et al., London, United Kingdom. In Plos One, 2009
A second member of this family, Themis2 (Q91YX0), also known as ICB1 (Induced on contact with basement membrane 1), remains unreported at the protein level despite microarray and EST databases reporting Themis2 mRNA expression in B cells and macrophages.
Single nucleotide polymorphisms in human gene icb-1 and breast cancer susceptibility.
Treeck et al., Regensburg, Germany. In Cancer Invest, 2009
Data suggest that SNP rs1467465 of human gene icb-1 might affect breast cancer susceptibility.
Expression of differentiation-associated gene icb-1 is estrogen-responsive in ovarian and breast cancer cell lines.
Treeck et al., Regensburg, Germany. In J Steroid Biochem Mol Biol, 2008
icb-1 (C1orf38) is a human gene initially described by our group to be upregulated during in vitro differentiation processes of endometrial adenocarcinoma and leukemia cells triggered by different stimuli.
Synthesis and evaluation of an intercalator-polyamide hairpin designed to target the inverted CCAAT box 2 in the topoisomerase IIalpha promoter.
Lee et al., Greenville, United States. In Chembiochem, 2006
Thermal-denaturation studies confirmed these results, and the highest degree of stabilization was found for ICB2 and -3 in preference to ICB1 (4.1, 4.6, and 0.6 degrees C, respectively).
Design of a hairpin polyamide, ZT65B, for targeting the inverted CCAAT box (ICB) site in the multidrug resistant (MDR1) gene.
Lee et al., Greenville, United States. In Chembiochem, 2005
DNase I-footprinting assays were carried out with the topoisomerase IIalpha-promoter sequence, which contains five ICB sites; of these, ICB1 and ICB5 are similar to the ICB site of MDR1.
Expression of icb-1 gene is interferon-gamma inducible in breast and ovarian cancer cell lines and affects the IFN gamma-response of SK-OV-3 ovarian cancer cells.
Ortmann et al., Regensburg, Germany. In Cytokine, 2005
The novel interferon-gamma inducible gene icb-1 is identified and its effects on the response of ovarian cancer cells to interferon-gamma are described
Targeting the inverted CCAAT box 2 in the topoisomerase IIalpha promoter by JH-37, an imidazole-pyrrole polyamide hairpin: design, synthesis, molecular biology, and biophysical studies.
Lee et al., Greenville, United States. In Biochemistry, 2004
Gel shift and DNase I footprinting studies on the topoisomerase IIalpha promoter showed JH-37 to preferentially bind to ICB2,3 and ICB1 sites.
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