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Catenin, beta interacting protein 1

iCAT, CTNNBIP1, inhibitor of beta-catenin and Tcf-4
The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, miR, V1a, TCF4
Papers on iCAT
Targeting the Wnt-Regulatory Protein CTNNBIP1 by microRNA-214 Enhances the Stemness and Self-Renewal of Cancer Stem-Like Cells in Lung Adenocarcinomas.
Zhu et al., Chongqing, China. In Stem Cells, Dec 2015
Here, we report that microRNA-214 (miR-214) contributes to cell self-renewal by directly targeting catenin beta interacting protein 1 (CTNNBIP1), a member of the Wnt signaling pathway.
MiR-215, an activator of the CTNNBIP1/β-catenin pathway, is a marker of poor prognosis in human glioma.
Li et al., Wuhan, China. In Oncotarget, Oct 2015
Additionally, CTNNBIP1, a direct target of miR-215, was decreased in glioma compared to adjacent normal tissue.
miR-603 promotes glioma cell growth via Wnt/β-catenin pathway by inhibiting WIF1 and CTNNBIP1.
Zheng et al., Harbin, China. In Cancer Lett, May 2015
We confirmed that WIF1 and CTNNBIP1 are bona fide targets of miR-603.
Effects of genistein and daidzein on cell proliferation kinetics in HT29 colon cancer cells: the expression of CTNNBIP1 (β-catenin), APC (adenomatous polyposis coli) and BIRC5 (survivin).
Mantovani et al., Londrina, Brazil. In Hum Cell, 2014
At a concentration of 50 μM genistein, there was suppressed expression of β-catenin (CTNNBIP1).
Identification of novel genes associated with renal tertiary lymphoid organ formation in aging mice.
Hillebrands et al., Groningen, Netherlands. In Plos One, 2013
Wisp2 (Chr2) showed the strongest association (P = 5.00×10(-137)) in male mice; Ctnnbip1 (P = 6.42×10(-267)) and Tnfrsf8 (P = 5.42×10(-245)) (both on Chr4) showed the strongest association in female mice.
MiR-424-5p reversed epithelial-mesenchymal transition of anchorage-independent HCC cells by directly targeting ICAT and suppressed HCC progression.
Han et al., Jinan, China. In Sci Rep, 2013
Target analysis showed that a potent β-catenin inhibitor, ICAT/CTNNBIP1 was a direct target of miR-424-5p.
Functional implications of microRNA-215 in TGF-β1-induced phenotypic transition of mesangial cells by targeting CTNNBIP1.
Feng et al., Chongqing, China. In Plos One, 2012
Luciferase reporter assays were used to identify whether catenin-beta interacting protein 1 (CTNNBIP1) is a direct target of miR-215, which was predicted by bioinformatic analysis.
MicroRNAs miR-26a, miR-26b, and miR-29b accelerate osteogenic differentiation of unrestricted somatic stem cells from human cord blood.
Wernet et al., Düsseldorf, Germany. In Bmc Genomics, 2012
We subsequently verified osteo-inhibitory CDK6, CTNNBIP1, HDAC4, and TOB1 and osteo-promoting SMAD1 as targets of these microRNAs.
Development of retinal pigment epithelium from human parthenogenetic embryonic stem cells and microRNA signature.
Li et al., Tianjin, China. In Invest Ophthalmol Vis Sci, 2012
CTNNBIP1 and TGFBR2 were confirmed to be the target genes of miR-204 and miR-302, respectively.
Clinically significant copy number alterations and complex rearrangements of MYB and NFIB in head and neck adenoid cystic carcinoma.
Stenman et al., Göteborg, Sweden. In Genes Chromosomes Cancer, 2012
Our studies also identified several down-regulated candidate tumor suppressor genes (CTNNBIP1, CASP9, PRDM2, and SFN) in 1p36.33-p35.3 that may be of clinical significance in high-grade tumors.
Orai1 and Ca2+-independent phospholipase A2 are required for store-operated Icat-SOC current, Ca2+ entry, and proliferation of primary vascular smooth muscle cells.
Bolotina et al., Boston, United States. In Am J Physiol Cell Physiol, 2012
Store-operated Ca(2+) entry (SOCE) is important for multiple functions of vascular smooth muscle cells (SMC), which, depending of their phenotype, can resemble excitable and nonexcitable cells.
β-Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial-mesenchymal transition.
Janes et al., London, United Kingdom. In J Pathol, 2012
Airway basal cell beta-catenin determines cell fate and its mis-expression is associated with the development of human lung cancer.
Epithelial-mesenchymal transition (EMT) protein expression in a cohort of stage II colorectal cancer patients with characterized tumor budding and mismatch repair protein status.
O'Sullivan et al., Dublin, Ireland. In Int J Surg Pathol, 2011
Microatellite-stable cases exhibited reduced membranous beta catenin and increased cytoplasmic and nuclear beta catenin compared with microsatellite-instable cases.
The beta-catenin binding protein ICAT modulates androgen receptor activity.
Sun et al., Stanford, United States. In Mol Endocrinol, 2011
Inhibitor of beta-catenin and T-cell factor (ICAT), a beta-catenin binding protein that inhibits the canonical Wnt/beta-catenin signaling pathway, in AR signaling, was investigated.
E2F1 suppresses Wnt/β-catenin activity through transactivation of β-catenin interacting protein ICAT.
Yu et al., Singapore, Singapore. In Oncogene, 2011
ICAT is a direct transcriptional target of E2F1, and activation of ICAT by E2F1 is required for E2F1 to inhibit beta-catenin activity.
MicroRNA-23 restricts cardiac valve formation by inhibiting Has2 and extracellular hyaluronic acid production.
Bakkers et al., Utrecht, Netherlands. In Circ Res, 2011
By in silico screening of expression data with predicted miR-23 target sites combined with in vivo testing, we identified hyaluronic acid synthase 2 (Has2), Icat, and Tmem2 as novel direct targets of miR-23.
Additive renoprotective effects of B2-kinin receptor blocker and PPAR-γ agonist in uninephrectomized db/db mice.
Lai et al., Hong Kong, Hong Kong. In Lab Invest, 2011
We recently showed that the bradykinin B2 receptor (B2R) blocker icatibant (Icat) and the peroxisome proliferator-activated receptor-γ agonist rosiglitazone (Ros) exerted anti-inflammatory effects in renal tubular cells exposed to a diabetic milieu.
High β-catenin/Tcf-4 activity confers glioma progression via direct regulation of AKT2 gene expression.
Kang et al., Tianjin, China. In Neuro Oncol, 2011
High beta-catenin is associated with glioma progression.
Expression of E-cadherin and β-catenin in two cholangiocarcinoma cell lines (OZ and HuCCT1) with different degree of invasiveness of the primary tumor.
Sergi et al., Edmonton, Canada. In Ann Clin Lab Sci, 2010
Cholangiocarcinoma cell lines express E-cad and beta-cat but with different localizat- ion patterns.
Ion channels in smooth muscle: regulators of intracellular calcium and contractility.
Nelson et al., Burlington, United States. In Can J Physiol Pharmacol, 2005
The nonselective cation channel family includes tonically active channels (Icat), as well as channels activated by agonists, pressure-stretch, and intracellular Ca2+ store depletion.
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