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Intercellular adhesion molecule 3

ICAM-3, CD50, intercellular adhesion molecule-3, telencephalin
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DC-SIGN, Intercellular Adhesion Molecule-1, CD11b, CAN, ICAM-2
Papers using ICAM-3 antibodies
The human CD6 gene is transcriptionally regulated by RUNX and Ets transcription factors in T cells.
Langmann Thomas, In PLoS ONE, 2008
... Phenotypic analysis was carried out by direct immunofluorescence using FITC-labeled anti-ICAM-3 (BD Biosciences) and FITC-labeled anti-CD163 monoclonal ...
Activity of Rho-family GTPases during cell division as visualized with FRET-based probes
Ridley Anne J. et al., In The Journal of Cell Biology, 2002
... Mellor, University of Bristol, UK), mouse anti-RhoJ, rabbit anti-RhoQ, goat anti-RhoU, rabbit anti-RhoBTB1, anti–ICAM-3 antibody (Abcam), RhoH antibody (provided by ...
Papers on ICAM-3
Allergy-Protective Arabinogalactan Modulates Human Dendritic Cells via C-Type Lectins and Inhibition of NF-κB.
Bufe et al., Bochum, Germany. In J Immunol, Feb 2016
In the search for a molecular mechanism, we found that AG binds to the immune modulatory receptors DC-specific ICAM-3 -: grabbing non integrin (DC-SIGN) and macrophage mannose receptor 1 (MMR-1).
Detection and quantitative analysis of two independent binding modes of a small ligand responsible for DC-SIGN clustering.
Nieto et al., Sevilla, Spain. In Org Biomol Chem, Feb 2016
DC-SIGN (dendritic cell-specific ICAM-3 grabbing non-integrin) is a C-type lectin receptor (CLR) present, mainly in dendritic cells (DCs), as one of the major pattern recognition receptors (PRRs).
Vitamin C Attenuates Hemorrhagic Hypotension Induced Epithelial-Dendritic Cell Transformation in Rat Intestines by Maintaining GSK-3β Activity and E-Cadherin Expression.
Mao et al., Shanghai, China. In Shock, Jan 2016
OBJECTIVE: To investigate the roles of epithelial-dendritic cell transformation (EDT) characterized by the expression of dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) in the occurrence of tissue inflammation induced by hemorrhagic hypotension (HH), the protective effect of vitamin C (VitC), and the potential mechanisms.
Association Between Intercellular Adhesion Molecule (Icam)-1, -2, -3 Plasma Levels and Disease Activity Of Ankylosing Spondylitis in The Chinese Han Population.
Wan et al., Zhengzhou, China. In Spine (phila Pa 1976), Jan 2016
There was no difference between controls and patients in term of ICAM-3 levels.
The role of human dendritic cells in HIV-1 infection.
Piguet et al., Cardiff, United Kingdom. In J Invest Dermatol, May 2015
DC studies have led to remarkable discoveries, including identification of restriction factors, cellular structures promoting viral transmission including the infectious synapse or the interplay of the C-type lectins, Langerin on Langerhans cells (LCs), and dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin on other DC subsets, limiting or facilitating HIV transmission to CD4(+) T cells, respectively.
[Research on hepatitis C virus entry inhibitor].
Zhu et al., In Bing Du Xue Bao, 2015
the process of HCV entering into host cell is the important step of drug intervention, in which HCV envelope protein El and E2, Host cell factors including Heparan sulfate(HS), CD81, scavenger receptor class B type I (SR-BI), Occludin (OCLD), Claudin (CLDN), low densitity lipoprotein receptor (LDLR), dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN), Liver/lymph node specific ICAM-3-grabbing integrin(L-SIGN), trans- ferrin receptor 1 (TfR1) and so on play a important role.
Effect of Culture Supernatant Derived from Trichophyton Rubrum Grown in the Nail Medium on the Innate Immunity-related Molecules of HaCaT.
Chen et al., Guangzhou, China. In Chin Med J (engl), 2014
The slight increase of dendritic cells-specific intercellular adhesion molecule 3-grabbing nonintegrin expression was faster and stronger, induced by T1a supernatant than T XHB .
ICAM-5: a neuronal dendritic adhesion molecule involved in immune and neuronal functions.
Paetau et al., In Adv Neurobiol, 2013
The neuron-specific intercellular adhesion molecule-5 (ICAM-5, telencephalin) is a member of the ICAM family of adhesion proteins.
Targeting the C-type lectins-mediated host-pathogen interactions with dextran.
Khan et al., Novosibirsk, Russia. In J Pharm Pharm Sci, 2013
Dextran-binding receptors in humans include the DC-SIGN (dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin) family receptors: DC-SIGN (CD209) and L-SIGN (the liver and lymphatic endothelium homologue of DC-SIGN), the mannose receptor (CD206), and langerin.
The physiological role of DC-SIGN: a tale of mice and men.
van Kooyk et al., Amsterdam, Netherlands. In Trends Immunol, 2013
The innate immune receptor DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin) was discovered over a decade ago and was initially identified as a pattern recognition receptor.
ARF6-mediated endosomal transport of Telencephalin affects dendritic filopodia-to-spine maturation.
Annaert et al., Leuven, Belgium. In Embo J, 2012
A specific microenvironment facilitating ARF6-mediated mobilization of TLN that contributes to promotion of dendritic spine development.
Spatial coordination of kindlin-2 with talin head domain in interaction with integrin β cytoplasmic tails.
Plow et al., Cleveland, United States. In J Biol Chem, 2012
Kindlin-2 and talin head do not interact with one another but can bind simultaneously to the integrin beta(3) tail without enhancing or inhibiting the interaction of the other binding partner.
Arginylation-dependent regulation of a proteolytic product of talin is essential for cell-cell adhesion.
Kashina et al., Philadelphia, United States. In J Cell Biol, 2012
a novel proteolytic product of talin that is regulated by arginylation and a new role of talin in cadherin-dependent cell-cell adhesion.
RUNX3 regulates intercellular adhesion molecule 3 (ICAM-3) expression during macrophage differentiation and monocyte extravasation.
Puig-Kröger et al., Madrid, Spain. In Plos One, 2011
Results indicate that the ICAM-3 gene promoter is negatively regulated by RUNX3.
An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells.
Drukker et al., Stanford, United States. In Nat Biotechnol, 2011
To ensure complete removal of teratoma-forming cells, we identified additional pluripotency surface markers (PSMs) exhibiting a large dynamic expression range during differentiation: CD9, CD30, CD50, CD90 and CD200.
Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway.
Ravetch et al., New York City, United States. In Nature, 2011
This anti-inflammatory activity of intravenous immunoglobulin is triggered by a minor population of IgG crystallizable fragments (Fcs), with glycans terminating in α2,6 sialic acids (sFc) that target myeloid regulatory cells expressing the lectin dendritic-cell-specific ICAM-3 grabbing non-integrin (DC-SIGN; also known as CD209).
Talin1, a valuable marker for diagnosis and prognostic assessment of human hepatocelluar carcinomas.
Xiong et al., Hefei, China. In Asian Pac J Cancer Prev, 2010
Low Talin1 is associated with hepatocelluar carcinoma.
A variant in the CD209 promoter is associated with severity of dengue disease.
Julier et al., Paris, France. In Nat Genet, 2005
Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN1, encoded by CD209), an attachment receptor of dengue virus, is essential for productive infection of dendritic cells.
Diversity of receptors binding HIV on dendritic cell subsets.
Cunningham et al., Sydney, Australia. In Nat Immunol, 2002
DC-SIGN (DC-specific ICAM-3-grabbing nonintegrin) was only expressed by CD14(+)CDla(lo) dermal DCs.
Role of ICAM-3 in the initial interaction of T lymphocytes and APCs.
Sánchez-Madrid et al., Madrid, Spain. In Nat Immunol, 2002
Here we show, through time-lapse imaging of live cells, that the intercellular adhesion molecule 3 (ICAM-3, also known as CD50) is clustered specifically at the region of the T lymphocyte surface that initiates contact with APCs.
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