gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Mitogen-activated protein kinase 8 interacting protein 1

IB1, Skip, JIP-1
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: HAD, CAN, AGE, JNK, IIa
Papers using IB1 antibodies
Coordinated transport of phosphorylated amyloid-β precursor protein and c-Jun NH2-terminal kinase–interacting protein-1
Muresan Virgil et al., In The Journal of Cell Biology, 1998
... The following anti–JIP-1 and anti–JIP-2 antibodies were used: goat (E-19) and mouse (B-7) anti–JIP-1; goat (C-20) and rabbit (H-95) anti–JIP-2 (all obtained from Santa Cruz Biotechnology, Inc.); and rabbit anti–JIP-1 ...
Papers on IB1
Sexual divergence in microtubule function: the novel intranasal microtubule targeting SKIP normalizes axonal transport and enhances memory.
Gozes et al., Tel Aviv-Yafo, Israel. In Mol Psychiatry, Feb 2016
Here, we reveal SKIP, a novel four-amino-acid peptide representing an EB-binding site, as a replacement therapy in an outbred Adnp-deficient mouse model.
Risk of Parametrial Spread in Small Stage I Cervical Carcinoma: Pathology Review of 223 Cases With a Tumor Diameter of 20 mm or Less.
Kesic et al., Belgrade, Serbia. In Int J Gynecol Cancer, Feb 2016
METHODS: Pathology review was done on patients with stages IA2 and small IB1, treated by radical hysterectomy and pelvic lymph node dissection.
Prognostic value of ABO blood group in patients with early stage cervical cancer treated with radical hysterectomy with pelvic node dissection.
Atjimakul et al., Thailand. In Tumour Biol, Jan 2016
The cohort included 413 patients diagnosed with stages IA2-IB1 cervical cancer who received a radical hysterectomy between 2002 and 2014.
Early stage cervical cancer: Brachytherapy followed by type a hysterectomy versus type B radical hysterectomy alone, a retrospective evaluation.
Lambaudie et al., Limoges, France. In Eur J Surg Oncol, Jan 2016
MATERIALS AND METHODS: It is a retrospective and collaborative study between the Paoli Calmettes Institute (Marseille) and the Oscar Lambret Center (Lille) from 2001 to 2013, in patients with tumors FIGO stages IA1, IA2, IB1 and IIA less than 2 cm of diameter, without pelvic lymph node involvement.
The sentinel node procedure in early stage cervical cancer, taking the next step; a diagnostic review.
Bekkers et al., Nijmegen, Netherlands. In Gynecol Oncol, Dec 2015
Prerequisites such as early FIGO stage (IA2, IB1, IIA primary tumor size <40mm), no suspicious pre-, and per-operative lymph nodes, and bilateral negative SLNs after ultra staging resulted in 1 remaining false negative result among 1257 patients (0.08%).
The phosphatidylinositol 3-kinase/Akt and c-Jun N-terminal kinase signaling in cancer: Alliance or contradiction? (Review).
Tony To et al., Hong Kong, Hong Kong. In Int J Oncol, Aug 2015
Activation of PI3K/Akt signaling can inhibit stress- and cytokine-induced JNK activation through Akt antagonizing and the formation of the JIP1-JNK module, as well as the activities of upstream kinases ASK1, MKK4/7 and MLK.
Small cell carcinoma of the uterine cervix: a case report and literature review.
Rodríguez et al., In Bol Asoc Med P R, 2015
We describe the case of a 41 year old female patient with a rare, and aggressive, clinical stage IB1 small cell neuroendocrine carcinoma of the cervix.
Management of Early Stage Cervical Cancer.
Ashwin et al., India. In Rev Recent Clin Trials, 2014
Stage IB1 cervical cancer is managed by either radical hysterectomy or radiotherapy with similar recurrence and survival rates.
Fertility-Preserving Treatments in Patients with Gynecological Cancers: Chinese Experience and Literature Review.
Ling et al., Beijing, China. In Asian Pac J Cancer Prev, 2014
With cervical cancer, radical trachelectomy(RT) in combination with pelvic lymphadenectomy could preserve the fertility of patients with early stage IA1-IB1 cancers, Tumor size≤2 cm should be emphasized as the indication of RT in considering of the higher recurrent rate in patients with tumor size>2 cm.
Structural basis for kinesin-1:cargo recognition.
Dodding et al., London, United Kingdom. In Science, 2013
Here, we present the crystal structure of the tetratricopeptide repeat domain of kinesin light chain 2 in complex with a cargo peptide harboring a "tryptophan-acidic" motif derived from SKIP (SifA-kinesin interacting protein), a critical host determinant in Salmonella pathogenesis and a regulator of lysosomal positioning.
Salmonella inhibits retrograde trafficking of mannose-6-phosphate receptors and lysosome function.
Holden et al., London, United Kingdom. In Science, 2012
This required binding of SifA to its host cell target SKIP/PLEKHM2.
Role of phosphatidylinositol 3,4,5-trisphosphate (PIP3) 5-phosphatase skeletal muscle- and kidney-enriched inositol polyphosphate phosphatase (SKIP) in myoblast differentiation.
Takenawa et al., Kōbe, Japan. In J Biol Chem, 2012
SKIP controls the IGF-II-PI 3-kinase-Akt-mTOR auto-regulation loop during myogenesis.
Regulation of insulin signaling by the phosphatidylinositol 3,4,5-triphosphate phosphatase SKIP through the scaffolding function of Pak1.
Takenawa et al., Kōbe, Japan. In Mol Cell Biol, 2012
Specific suppression of insulin signaling is achieved via the spatiotemporal regulation of SKIP through the scaffolding function of Pak1.
Arl8 and SKIP act together to link lysosomes to kinesin-1.
Munro et al., Cambridge, United Kingdom. In Dev Cell, 2012
Arl8 and SKIP are required for lysosomes to distribute away from the microtubule-organizing center. We identify two kinesin light chain binding motifs in SKIP that are required for lysosomes to accumulate kinesin-1 and redistribute to the cell periphery.
Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats.
Young et al., London, United Kingdom. In Plos One, 2011
Results showed that DPP6, SPHKAP and ID4 were down regulated in acute myeloid leukemia (AML) patients.
An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria.
Scott et al., Seattle, United States. In Proc Natl Acad Sci U S A, 2011
SKIP is an entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria.
Bilateral negative sentinel nodes accurately predict absence of lymph node metastasis in early cervical cancer: results of the SENTICOL study.
Dargent et al., Paris, France. In J Clin Oncol, 2011
PATIENTS AND METHODS: Adults with cervical carcinoma who met the International Federation of Gynecology and Obstetrics criteria for stage IA1 with lymphovascular space invasion to stage IB1 underwent technetium 99 lymphoscintigraphy and Patent Blue injection followed by laparoscopic lymph node mapping, SLN removal, and lymph node dissection.
The intracellular fate of Salmonella depends on the recruitment of kinesin.
Méresse et al., Marseille, France. In Science, 2005
A dynamic process of kinesin recruitment in Salmonella-infected cells is down-regulated by the SifA-mediated recruitment of SKIP on membranes [SKIP]
Preoperative serum squamous cell carcinoma antigen levels in clinical decision making for patients with early-stage cervical cancer.
van der Zee et al., Groningen, Netherlands. In J Clin Oncol, 2005
RESULTS: In patients with normal preoperative SCC-ag, 16% of IB1 and 29% of IB2/IIA had postoperative indications for adjuvant radiotherapy, in contrast to 57% of IB1 and 74% of IB2/IIA patients with elevated (> 1.9 ng/mL) serum SCC-ag (P < .001).
Results of Curative Radiotherapy Alone in Patients with Uterine Cervical Carcinomas.
Oh et al., In Cancer Res Treat, 2002
The number of patients with FIGO stage IB1, IB2, IIA, IIB, IIIA, IIIB and IVA were 61 (32.6%), 7 (3.7%),
share on facebooktweetadd +1mail to friends