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Protein tyrosine phosphatase, receptor type, N polypeptide 2

IAR, IA-2beta
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IA-2, HAD, Insulin, LAR, CAN
Papers on IAR
In Vitro Demonstration of Dual Light-Driven Na⁺/H⁺ Pumping by a Microbial Rhodopsin.
Spudich et al., Houston, United States. In Biophys J, Nov 2015
We expressed IAR, an uncharacterized member from Indibacter alkaliphilus in E. coli cell suspensions, and observed similar ion fluxes as reported for KR2 from Dokdonia eikasta.
Implication of FKBP6 for male fertility in horses.
Distl et al., Hannover, Germany. In Reprod Domest Anim, Apr 2015
In stallions, impaired acrosome reaction (IAR) may often cause subfertility.
A Novel Role of E-Cadherin-Based Adherens Junctions in Neoplastic Cell Dissemination.
Gloushankova et al., Moscow, Russia. In Plos One, 2014
Using confocal microscopy, we analyzed the behavior of IAR-6-1, IAR1170, and IAR1162 transformed epithelial cells seeded onto the confluent monolayer of normal IAR-2 epithelial cells.
Structure and properties of the precursor/successor complex and transition state of the CrCl²⁺/Cr²⁺ electron self-exchange reaction via the inner-sphere pathway.
Rotzinger, Lausanne, Switzerland. In Inorg Chem, 2014
The overall rate constant (k) was estimated as the product K(A)k(et), whereby K(A) is the equilibrium constant for the formation of the ion aggregate of the reactants Cr(OH2)6(2+) and CrCl(OH2)5(2+), Cr(H2O)6·CrCl(OH2)5(4+) (IAR).
Expression of surface markers on the blood cells during the delayed asthmatic response to allergen challenge.
Pelikan, Breda, Netherlands. In Allergy Rhinol (providence), 2014
Patients with bronchial asthma develop various types of asthmatic response to bronchial challenge with allergen, such as immediate/early asthmatic response (IAR), late asthmatic response (LAR) or delayed asthmatic response (DYAR), because of different immunologic mechanisms.
Overexpression of juxtaposed with another zinc finger gene 1 reduces proinflammatory cytokine release via inhibition of stress-activated protein kinases and nuclear factor-κB.
Yang et al., Chongqing, China. In Febs J, 2014
JAZF1 overexpression vector was transfected into PA-treated IAR-20 hepatocytes.
Identification of novel resistance gene sources to cowpea aphid (Aphis craccivora Koch) in cowpea (Vigna unguiculata L.).
Ishiyaku et al., Zaria, Nigeria. In Pak J Biol Sci, 2013
The development of cowpea aphid larvae was monitored on seven cowpea genotypes (IAR-48, TVu-15866, IT84S-2246-4, SAKA BABBA SATA, IT90K-76, KANANNADO and TVX 3236).
The association between controlled interpersonal affect regulation and resource depletion.
Totterdell et al., Madrid, Spain. In Appl Psychol Health Well Being, 2013
BACKGROUND: This investigation focuses on what occurs to individuals' self-regulatory resource during controlled Interpersonal Affect Regulation (IAR) which is the process of deliberately influencing the internal feeling states of others.
A dihydrochalcone and several homoisoflavonoids from Polygonatum odoratum are activators of adenosine monophosphate-activated protein kinase.
Bai et al., Jinan, China. In Bioorg Med Chem Lett, 2013
The amount of active phosphorylated AMPK and acetyl-CoA carboxylase in rat liver epithelial IAR-20 cells increased when the cells were incubated with the aforementioned compounds.
Defective protein kinase A and C pathways are common causes of disordered zona pellucida (ZP)--induced acrosome reaction in normozoospermic infertile men with normal sperm-ZP binding.
Baker et al., Melbourne, Australia. In Fertil Steril, 2013
MAIN OUTCOMES MEASURE(S): Sperm-ZP binding and the ZP-induced IAR.
[Protective effects and mechanism of SP600125 on lung ischemia/reperfusion injury in rats].
Wang et al., Wenzhou, China. In Zhongguo Ying Yong Sheng Li Xue Za Zhi, 2012
The lung tissues sampled at the end of each experiment were assayed for wet/dry weight ratio (W/D),the injured alveoli rate (IAR), the expression of phosphorylation JNK (p-JNK) and JNK protein were detected by Western blot, the expression of Bcl-2, Bax, Caspase3 protein were detected by immunocytochemistry techniques, the pneumocyte apoptosis index (AI) was detected by terminal deoxynucleotidyl transferase mediated dUTP nick end abeling(TUNEL), the ultrastructure changes were observed under electron microscope.
Genome-wide association study implicates testis-sperm specific FKBP6 as a susceptibility locus for impaired acrosome reaction in stallions.
Chowdhary et al., College Station, United States. In Plos Genet, 2011
Impaired acrosomal reaction (IAR) of sperm causes male subfertility in humans and animals.
Deletion of the secretory vesicle proteins IA-2 and IA-2beta disrupts circadian rhythms of cardiovascular and physical activity.
Notkins et al., Bethesda, United States. In Faseb J, 2009
deletion of IA-2 and IA-2beta, structural proteins of secretory vesicles and modulators of neuroendocrine secretion, has a profound effect on the circadian system.
Disturbances in the secretion of neurotransmitters in IA-2/IA-2beta null mice: changes in behavior, learning and lifespan.
Notkins et al., Bethesda, United States. In Neuroscience, 2009
In mice IA-2beta expressed exclusively in dense core secretory vesicles (DCV) and with fractions rich in synaptic vesicles (SV) of neuroendocrine cells of brain and impairment of conditioned learning.
Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth.
Takeuchi et al., Maebashi, Japan. In Diabetes, 2009
Phogrin and IA-2 function as essential regulators of autocrine insulin action in pancreatic beta-cells.
Expression and function of IA-2 family proteins, unique neuroendocrine-specific protein-tyrosine phosphatases.
Torii, Maebashi, Japan. In Endocr J, 2008
IA-2 (also known as islet cell antigen ICA-512) and IA-2 beta (also known as phogrin, phosphatase homologue in granules of insulinoma) are major autoantigens in insulin-dependent diabetes mellitus (IDDM).
Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta.
Notkins et al., Brussels, Belgium. In J Endocrinol, 2008
IA-2 and IA-2beta are dispensable for exocytosis of insulin granules, but are probably more important for cargo loading and/or stability of dense core vesicles
IA-2beta, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion.
Nanjo et al., Wakayama, Japan. In Proc Natl Acad Sci U S A, 2006
IA-2beta, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion
Dynamic stabilization devices in the treatment of low back pain.
Sengupta, Royal Oak, United States. In Orthop Clin North Am, 2004
Any mismatch between the kinematics of the implant system and the motion segment, in particular any discrepancy between their IAR, would result in the implant bearing unexpected load at certain ranges of motion.
IA-2 and IA-2beta: the immune response in IDDM.
Leslie et al., Bethesda, United States. In Diabetes Metab Rev, 1998
Pancreatic islet cell autoantigens associated with insulin-dependent diabetes mellitus (IDDM) include a recently identified family of protein tyrosine phosphatase-like molecules, notably IA-2 and IA-2beta.
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