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Histocompatibility 2, class II antigen A, alpha

IA1, Ialpha
Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, IA-2, CAN, AGE, ACID
Papers on IA1
Molecular characterization of classical and nonclassical MHC class I genes from the golden pheasant (Chrysolophus pictus).
Wan et al., Hangzhou, China. In Int J Immunogenet, Jan 2016
Two (A and C) belonged to the IA1 gene, two (B and D) were alleles derived from the IA2 gene through transgene amplification, and two (E and F) comprised a third novel locus, IA3 that was excluded from the core region of the golden pheasant MHC-B.
99mTc-nanocolloid SPECT-MRI fusion for the selective assessment of non-enlarged sentinel lymph nodes in patients with early stage cervical cancer.
Veldhuis et al., Netherlands. In J Nucl Med, Jan 2016
METHODS: We consecutively included stage IA1 - IIB1 cervical cancer patients who presented to our tertiary referral center between March 2011 and February 2015.
Early stage cervical cancer: Brachytherapy followed by type a hysterectomy versus type B radical hysterectomy alone, a retrospective evaluation.
Lambaudie et al., Limoges, France. In Eur J Surg Oncol, Jan 2016
MATERIALS AND METHODS: It is a retrospective and collaborative study between the Paoli Calmettes Institute (Marseille) and the Oscar Lambret Center (Lille) from 2001 to 2013, in patients with tumors FIGO stages IA1, IA2, IB1 and IIA less than 2 cm of diameter, without pelvic lymph node involvement.
AGE-RAGE signal generates a specific NF-κB RelA "barcode" that directs collagen I expression.
Lin et al., Baltimore, United States. In Sci Rep, Dec 2015
In the current study, we established that AGE-RAGE signaling results in NF-κB activation that directs collagen Ia1 and Ia2 expression.
[Pregnancy and labor after fertility-sparing surgical management of cervical cancer].
Schwarz et al., In Ginekol Pol, Sep 2015
Out of them, 65 (85%) women underwent surgical conization (43--FIGO IA1 and 25--FIGO IA2), and 12 (15%) women underwent radical vaginal trachelectomy with laparoscopic lymphadenectomy (9--FIGO IA2 and 3--FIGO lB1).
Robotic radical hysterectomy in early stage cervical cancer: A systematic review and meta-analysis.
Famuyide et al., Rochester, United States. In Gynecol Oncol, Aug 2015
We included studies comparing surgical approaches to radical hysterectomy (robotic vs. laparoscopic or abdominal, or both) in women with stages IA1-IIA cervical cancer.
Fertility-Preserving Treatments in Patients with Gynecological Cancers: Chinese Experience and Literature Review.
Ling et al., Beijing, China. In Asian Pac J Cancer Prev, 2014
With cervical cancer, radical trachelectomy(RT) in combination with pelvic lymphadenectomy could preserve the fertility of patients with early stage IA1-IB1 cancers, Tumor size≤2 cm should be emphasized as the indication of RT in considering of the higher recurrent rate in patients with tumor size>2 cm.
Management of Early Stage Cervical Cancer.
Ashwin et al., India. In Rev Recent Clin Trials, 2014
Patients with stromal invasion of less than 3 mm (stage IA1) with no lymphovascular involvement are treated conservatively with simple hysterectomy and in selected patients who desire fertility, cone biopsy with negative surgical margins is an option.
Radical trachelectomy: the first step of fertility preservation in young women with cervical cancer (Review).
Nardelli et al., Padova, Italy. In Oncol Rep, 2013
A total of 1293 RTs were analyzed (FIGO-stage: IA1-IIA).
Patient-tailored conservative surgical treatment of invasive uterine cervical squamous cell carcinoma. A review.
Menczer, H̱olon, Israel. In Minerva Ginecol, 2013
Conization only is optimal for women with stage Ia1 disease mainly in tumors without lymph vascular space involvement (LVSI).
Functional role of an islet transcription factor, INSM1/IA-1, on pancreatic acinar cell trans-differentiation.
Lan et al., New Orleans, United States. In J Cell Physiol, 2012
Both the AR42J cell line and the primary cultured mouse acinar cells support role for INSM1 in pancreatic acinar cell trans-differentiation model.
MHC class II upregulation and colocalization with Fas in experimental models of immune-mediated bone marrow failure.
Chen et al., Bethesda, United States. In Exp Hematol, 2011
Data show that MHC class II(+)Fas(+) BM cells were closely associated with CD4(+) T cells in the BM of affected animals.
Bilateral negative sentinel nodes accurately predict absence of lymph node metastasis in early cervical cancer: results of the SENTICOL study.
Dargent et al., Paris, France. In J Clin Oncol, 2011
PATIENTS AND METHODS: Adults with cervical carcinoma who met the International Federation of Gynecology and Obstetrics criteria for stage IA1 with lymphovascular space invasion to stage IB1 underwent technetium 99 lymphoscintigraphy and Patent Blue injection followed by laparoscopic lymph node mapping, SLN removal, and lymph node dissection.
Insm1 promotes the transition of olfactory progenitors from apical and proliferative to basal, terminally dividing and neuronogenic.
García-Añoveros et al., Chicago, United States. In Neural Dev, 2010
This study suggested that Insm1 in promoting the transition of progenitors from apical and proliferative to basal, terminal and neuronogenic.
Herpes simplex virus induces the marked up-regulation of the zinc finger transcriptional factor INSM1, which modulates the expression and localization of the immediate early protein ICP0.
Nishiyama et al., Nagoya, Japan. In Virol J, 2010
The results suggest that INSM1 up-regulation plays a positive role in HSV-1 replication, probably by binding to the ICP0 promoter.
Insulinoma-associated antigen-1 zinc-finger transcription factor promotes pancreatic duct cell trans-differentiation.
Lan et al., New Orleans, United States. In Endocrinology, 2010
Data show that the consistent functional effect of INSM1, either with or without other ITFs, promotes pancreatic duct cell differentiation as well as induces Panc-1 cell cycle arrest.
Cysteine redox sensor in PKGIa enables oxidant-induced activation.
Eaton et al., London, United Kingdom. In Science, 2007
The Ialpha isoform, PKGIalpha, formed an interprotein disulfide linking its two subunits in cells exposed to exogenous hydrogen peroxide.
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism.
He et al., Boston, United States. In Cell, 2002
This "priming" kinase is casein kinase Ialpha (CKIalpha).
Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha.
Mendelsohn et al., Boston, United States. In Science, 1999
Cyclic guanosine monophosphate (cGMP)-dependent protein kinase Ialpha (cGKIalpha) mediates physiologic relaxation of vascular smooth muscle in response to nitric oxide and cGMP.
Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1.
McKeon et al., Boston, United States. In Cell, 1998
Casein kinase Ialpha directly binds and phosphorylates NF-AT4, resulting in the inhibiton of NF-AT4 nuclear translocation.
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