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Zinc finger protein 124

HZF16, ZNF124
This gene encodes a member of the Kruppel-type (C2H2) zinc finger protein family. It has a KRAB-A box at its amino terminus and seven consecutively repeated zinc finger motifs at its carboxy terminus. Expression of this gene is increased after vascular endothelial growth factor (VEGF) stimulation in human leukemia cell lines and its expression inhibits apoptotic cell death induced by irradiation or exposure to etoposide. These attributes suggest that this protein may act as a transcription factor. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described for this gene but their biological validity has not been confirmed. This gene has a pseudogene on chromosome 14. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: Mps1, FUS, Src, SENP2, myosin X
Papers on HZF16
Reconstruction of an integrated genome-scale co-expression network reveals key modules involved in lung adenocarcinoma.
Masoudi-Nejad et al., Tehrān, Iran. In Plos One, 2012
The genes EGFR, PIK3CA, TAF15, XIAP, VAPB, Appl1, Rab5a, ARF4, CLPTM1L, SP4, ZNF124, LPP, FOXP1, SOX18, MSX2, NFE2L2, SMARCC1, TRA2B, CBX3, PRPF6, ATP6V1C1, MYBBP1A, MACF1, GRM2, TBXA2R, PRKAR2A, PTK2, PGF and MYO10 are among the genes that belong to modules 1 and 22.
Four patients with speech delay, seizures and variable corpus callosum thickness sharing a 0.440 Mb deletion in region 1q44 containing the HNRPU gene.
Poot et al., Kiel, Germany. In Eur J Med Genet, 2010
Since only one of the two patients with deletions including the ZNF124 gene showed a vermis hypoplasia, mere hemizygosity for this gene is not sufficient to cause this anomaly.
Dandy-Walker complex in a boy with a 5 Mb deletion of region 1q44 due to a paternal t(1;20)(q44;q13.33).
Hochstenbach et al., Utrecht, Netherlands. In Am J Med Genet A, 2007
Since the ZNF124 transcription factor is strongly expressed in the fetal brain it may represent a candidate gene for the DWC at 1q44.
ZK7, a novel zinc finger gene, is induced by vascular endothelial growth factor and inhibits apoptotic death in hematopoietic cells.
Katoh et al., Hiroshima, Japan. In Cancer Res, 2000
These ZNF motifs were identical to those of HZF16 (M.
A novel zinc finger gene on human chromosome 1qter that is alternatively spliced in human tissues and cell lines.
Evans et al., San Diego, United States. In Am J Hum Genet, 1993
One cDNA (i.e., HZF-16.2) has nine zinc finger domains, while alternative splicing of the message gives rise to a smaller product (i.e., HZF-16.1) that has four domains.
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