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Hif-1a hypoxia-inducible factor 1 alpha

hypoxia-inducible factor 1alpha
Top mentioned proteins: HIF-1alpha, vascular endothelial growth factor, CAN, V1a, HAD
Papers on hypoxia-inducible factor 1alpha
Expression and significance of HIF-1α and HIF-2α in pancreatic cancer.
Jiang et al., Wuhan, China. In J Huazhong Univ Sci Technolog Med Sci, Dec 2015
The expression levels of hypoxia-inducible factor 1alpha (HIF-1α) and HIF-2α in pancreatic cancer (PC) and their association with clinicopathologic characteristics were investigated in order to elucidate their roles in the development of PC.
HIF-1α Mediates Isoflurane-Induced Vascular Protection in Subarachnoid Hemorrhage.
Zipfel et al., Saint Louis, United States. In Ann Clin Transl Neurol, Apr 2015
Isoflurane-induced changes in hypoxia-inducible factor 1alpha (HIF-1α)-dependent genes were assessed via quantitative polymerase chain reaction.
Hyperbaric oxygen therapy ameliorates TNBS-induced acute distal colitis in rats.
Féres et al., Ribeirão Preto, Brazil. In Med Gas Res, 2014
BACKGROUND: This study investigated the therapeutic effects of hyperbaric oxygen in experimental acute distal colitis focusing on its effect on the production of pro-inflammatory cytokines, nitric oxide and hypoxia-inducible factor 1alpha.
PP085. Angiotensin II type 1 receptor antibodies increase angiotensin II sensitivity in pregnant rats.
Dechend et al., Berlin, Germany. In Pregnancy Hypertens, 2012
We next performed gene-array profiling of the uteroplacental unit and found that hypoxia-inducible factor 1alpha was upregulated by Ang II plus AT1-AB, which we then confirmed by Western blotting in villous explants.
Increased hypoxia-inducible factor 1alpha expression in rat brain tissues in response to aging.
Zhan et al., Xi'an, China. In Neural Regen Res, 2012
The present study observed changes in rat neural cells at various ages (3, 18, 24, and 30 months).
Thyroid hormone and angiogenesis.
Davis et al., Albany, United States. In Vascul Pharmacol, 2010
The hormone may also induce expression of the hypoxia-inducible factor 1alpha (HIF1alpha) gene, a transcription factor important to coronary artery collateralization in the setting of hypoxia.
Posttranslational modifications of collagens as targets of hypoxia and Hif-1alpha in endochondral bone development.
Schipani, Boston, United States. In Ann N Y Acad Sci, 2010
A crucial mediator of the adaptive response of cells to hypoxia is the transcription factor hypoxia-inducible factor 1alpha (Hif-1alpha).
Prognostic significance of hypoxia-inducible factor-1alpha, TWIST1 and Snail expression in resectable non-small cell lung cancer.
Wu et al., Taipei, Taiwan. In Thorax, 2009
Intratumoral hypoxia followed by stabilisation of hypoxia-inducible factor 1alpha (HIF-1alpha) promotes metastasis through regulation of certain EMT regulators.
Oxygen sensing in the carotid body.
Gómez-Díaz et al., Sevilla, Spain. In Ann N Y Acad Sci, 2009
We discuss here the role in CB oxygen sensing of the hypoxia-inducible factor 1alpha, the mitochondrial complex II subunit D, and heme oxygenase 2. In chronic hypoxia the CB grows with increase in glomus cell number.
Molecular mechanisms of thrombopoietin signaling.
Kaushansky, San Diego, United States. In J Thromb Haemost, 2009
Additional signals activated by these secondary mediators include mammalian target of rapamycin, beta-catenin, hypoxia-inducible factor 1alpha and the homeobox proteins HOXB4 and HOXA9, and a number that are reduced, including glycogen synthase kinase 3alpha and the FOXO3 family of forkhead proteins.
Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia.
Eltzschig et al., Tübingen, Germany. In Nat Immunol, 2009
We detected hypoxia-inducible factor 1alpha (HIF-1alpha)-dependent induction of expression of the gene encoding netrin-1 (Ntn1) in hypoxic epithelia.
Phosphorylated ERalpha, HIF-1alpha, and MAPK signaling as predictors of primary endocrine treatment response and resistance in patients with breast cancer.
Fox et al., Oxford, United Kingdom. In J Clin Oncol, 2009
Twenty-four tumor proteins involved in apoptosis, cell survival, hypoxia, angiogenesis, growth factor, and hormone signaling were assessed by immunohistochemistry in pretreatment samples (eg, caspase 3, phospho- mammalian target of rapamycin, hypoxia-inducible factor 1alpha [HIF-1alpha], vascular endothelial growth factor, mitogen-activated protein kinase [MAPK], phosphorylated epidermal growth factor receptor, phosphorylated ERalpha [pERalpha]).
HDAC4 regulates neuronal survival in normal and diseased retinas.
Cepko et al., Boston, United States. In Science, 2009
The survival effect was due to the activity of HDAC4 in the cytoplasm and relied at least partly on the activity of hypoxia-inducible factor 1alpha (HIF1alpha).
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.
Deshaies et al., Pasadena, United States. In Cell, 2008
In particular, UBXD7 links p97 to the ubiquitin ligase CUL2/VHL and its substrate hypoxia-inducible factor 1alpha (HIF1alpha).
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia.
Yeh et al., Houston, United States. In Cell, 2007
We determine that SENP1 controls Epo production by regulating the stability of hypoxia-inducible factor 1alpha (HIF1alpha) during hypoxia.
Short upstream region drives dynamic expression of hypoxia-inducible factor 1alpha during Xenopus development.
Saha et al., United States. In Dev Dyn, 2004
xHIF-1alpha mRNA is constitutively expressed at low levels throughout embryogenesis, but with significant up-regulation during gastrula stages, and subsequently, in specific regions of the central nervous system and axial tissues.
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