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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


hypocretin, orexin-A, hypocretin-1, orexin-B
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010] (from NCBI)
Top mentioned proteins: Neuropeptide, HAD, CAN, V1a, AGE
Papers on hypocretin
Orexin in Rostral Hotspot of Nucleus Accumbens Enhances Sucrose 'Liking' and Intake but Scopolamine in Caudal Shell Shifts 'Liking' Toward 'Disgust' and 'Fear'.
Berridge et al., Ann Arbor, United States. In Neuropsychopharmacology, Feb 2016
Within NAc shell, orexin/hypocretin also has been reported to stimulate food intake and is implicated in reward, whereas blockade of muscarinic acetylcholine receptors by scopolamine suppresses intake and may have anti-reward effects.
Orexin/hypocretin neuron activation is correlated with alcohol seeking and preference in a topographically specific manner.
Aston-Jones et al., Amherst Center, United States. In Eur J Neurosci, Feb 2016
UNASSIGNED: Orexin (ORX, also known as hypocretin, HRCT) neurons are located exclusively in the posterior hypothalamus and are involved in a wide range of behaviors, including motivation for drugs of abuse such as alcohol.
Sleep Pharmacogenetics: Personalized Sleep-Wake Therapy.
Landolt et al., Zürich, Switzerland. In Annu Rev Pharmacol Toxicol, Feb 2016
Research spanning (genetically engineered) animal models, healthy volunteers, and sleep-disordered patients has identified the neurotransmitters and neuromodulators dopamine, serotonin, norepinephrine, histamine, hypocretin, melatonin, glutamate, acetylcholine, γ-amino-butyric acid, and adenosine as important players in the regulation and maintenance of sleep-wake-dependent changes in neuronal activity and the sleep-wake continuum.
Decline of CSF orexin (hypocretin) levels in Prader-Willi syndrome.
Kanbayashi et al., Akita, Japan. In Am J Med Genet A, Feb 2016
As is the case in narcolepsy, orexin (hypocretin) may be responsible for these symptoms.
Nuclear organisation of some immunohistochemically identifiable neural systems in five species of insectivore-Crocidura cyanea, Crocidura olivieri, Sylvisorex ollula, Paraechinus aethiopicus and Atelerix frontalis.
Manger et al., Johannesburg, South Africa. In J Chem Neuroanat, Jan 2016
Brains of insectivores were coronally sectioned and immunohistochemically stained with antibodies against choline acetyltransferase, tyrosine hydroxylase, serotonin and orexin-A.
Orexins excite ventrolateral geniculate nucleus neurons predominantly via OX2 receptors.
Lewandowski et al., Kraków, Poland. In Neuropharmacology, Jan 2016
Orexin A/hypocretin-1 (OXA) and orexin B/hypocretin-2 (OXB) bind to two metabotropic receptors, named the OX1 and OX2 receptors.
Challenges in the development of therapeutics for narcolepsy.
Kilduff et al., Menlo Park, United States. In Prog Neurobiol, Jan 2016
Disruption of neurotransmission through the hypocretin/orexin (Hcrt) system, usually by degeneration of the HCRT-producing neurons in the posterior hypothalamus, results in narcolepsy.
Orexin and sleep quality in anorexia nervosa: Clinical relevance and influence on treatment outcome.
Fernández-Aranda et al., Barcelona, Spain. In Psychoneuroendocrinology, Jan 2016
The aims of the current study were to evaluate the extent to which orexin-A might be linked to sleep and treatment outcome in AN.
The Neurobiology of Sleep and Wakefulness.
Kilduff et al., Menlo Park, United States. In Psychiatr Clin North Am, Dec 2015
These wake-promoting systems are regulated by hypothalamic hypocretin/orexins, while GABAergic sleep-promoting nuclei are found in the preoptic area, brainstem and lateral hypothalamus.
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant.
Rosenbaum et al., Dallas, United States. In Nature, Apr 2015
The human OX2 receptor (OX2R) belongs to the β branch of the rhodopsin family of GPCRs, and can bind to diverse compounds including the native agonist peptides orexin-A and orexin-B and the potent therapeutic inhibitor suvorexant.
Hypocretin (orexin) biology and the pathophysiology of narcolepsy with cataplexy.
Tafti et al., Toulouse, France. In Lancet Neurol, Mar 2015
Narcolepsy with cataplexy is caused by hypocretin deficiency owing to destruction of most of the hypocretin-producing neurons in the hypothalamus.
Treatment paradigms for cataplexy in narcolepsy: past, present, and future.
Swick, Houston, United States. In Nat Sci Sleep, 2014
It is now generally considered that loss of signaling by hypothalamic hypocretin/orexin-producing neurons plays a key role in the development of cataplexy.
Neural plasticity in hypocretin neurons: the basis of hypocretinergic regulation of physiological and behavioral functions in animals.
Hermes et al., New Haven, United States. In Front Syst Neurosci, 2014
The neuronal system that resides in the perifornical and lateral hypothalamus (Pf/LH) and synthesizes the neuropeptide hypocretin/orexin participates in critical brain functions across species from fish to human.
Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination.
Vaarala et al., Helsinki, Finland. In Lancet Neurol, 2014
Narcolepsy is a sleep disorder characterised by loss of hypothalamic hypocretin (orexin) neurons.
Function and dysfunction of hypocretin/orexin: an energetics point of view.
Horvath et al., New Haven, United States. In Annu Rev Neurosci, 2013
The orexin/hypocretin system in the perifornical/lateral hypothalamus, which was discovered 15 years ago, is one such specialized area.
Optogenetic probing of fast glutamatergic transmission from hypocretin/orexin to histamine neurons in situ.
Burdakov et al., Cambridge, United Kingdom. In J Neurosci, 2012
Hypocretin/orexin neurons are capable of fast glutamatergic control of their projection targets by inducing changes in signals generated by histamine neurons.
The social defeat animal model of depression shows diminished levels of orexin in mesocortical regions of the dopamine system, and of dynorphin and orexin in the hypothalamus.
Panksepp et al., Cleveland, United States. In Neuroscience, 2012
These findings suggest that orexin and dynorphin function may be imbalanced between the hypothalamus and mesocortical dopaminergic brain regions in depression.
EEG effect of orexin A in freely moving rats.
Detari et al., Budapest, Hungary. In Acta Physiol Hung, 2012
Orexin A administration differently affected fronto-occipital EEG waves in the different frequency bands recorded for 24 hours. Delta (1-4 Hz) and alpha (10-16 Hz) power decreased, while theta (4-10 Hz) and beta (16-48 Hz) power increased.
Orexin A decreases lipid peroxidation and apoptosis in a novel hypothalamic cell model.
Kotz et al., Saint Paul, United States. In Neurosci Lett, 2012
Our data support the hypothesis that orexin A (OxA) may promote obesity resistance both by increasing spontaneous physical activity, and by influencing survival of OxA-responsive hypothalamic neurons.
Differential orexin/hypocretin expression in addiction-prone and -resistant rats selectively bred for high (HiS) and low (LoS) saccharin intake.
Carroll et al., Minneapolis, United States. In Neurosci Lett, 2012
the orexin system may be involved in aspects of genetically-mediated differences in vulnerability to compulsive, reward-driven behaviors.
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