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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Hyaluronoglucosaminidase 4

HYAL4, hyaluronidase-4, hyaluronidase IV
This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: hyaluronidase, HYAL3, HYAL2, ACID, CD44
Papers on HYAL4
Genome-Wide Association Study of Golden Retrievers Identifies Germ-Line Risk Factors Predisposing to Mast Cell Tumours.
Lindblad-Toh et al., Uppsala, Sweden. In Plos Genet, Nov 2015
In addition, disease associated haplotypes harbouring the hyaluronidase genes HYAL1, HYAL2 and HYAL3 on cfa20 and HYAL4, SPAM1 and HYALP1 on cfa14 were identified as separate risk factors in European and US golden retrievers, respectively, suggesting that turnover of hyaluronan plays an important role in the development of CMCT.
Expression of hyaluronidase-4 in a rat spinal cord hemisection model.
Matsumoto et al., Kanazawa, Japan. In Asian Spine J, Feb 2015
STUDY DESIGN: Examination of hyaluronidase-4 (Hyal-4) expression in a rat spinal cord hemisection model.
Elevated hyaluronan and hyaluronan-mediated motility receptor are associated with biochemical failure in patients with intermediate-grade prostate tumors.
Schmechel et al., Minneapolis, United States. In Cancer, 2014
Hyaluronan (HA) is a high molecular weight polyanionic carbohydrate produced by synthases (HAS1 through HAS3) and fragmented by oxidative/nitrosative stress and hyaluronidases (HYAL1 through HYAL4, SPAM1) common in PCa microenvironments.
Identification of amino acid residues required for the substrate specificity of human and mouse chondroitin sulfate hydrolase (conventional hyaluronidase-4).
Yamada et al., Sapporo, Japan. In J Biol Chem, 2013
Human hyaluronidase-4 (hHYAL4), a member of the hyaluronidase family, has no hyaluronidase activity, but is a chondroitin sulfate (CS)-specific endo-β-N-acetylgalactosaminidase.
Distinct genomic aberrations between low-grade and high-grade gliomas of Chinese patients.
Fu et al., Changchun, China. In Plos One, 2012
Subsequently, we confirmed well-characterized oncogenes among tumor-related loci (such as EGFR and KIT) and detected novel genes that gained chromosome sequences (such as AASS, HYAL4, NDUFA5 and SPAM1) in both LGG and HGG.
Vascular complications of hyaluronic acid fillers and the role of hyaluronidase in management.
Dhong et al., Ansan, South Korea. In J Plast Reconstr Aesthet Surg, 2011
Five rabbits each received a subcutaneous injection of 750 IU of hyaluronidase 4 and 24 h after the filler injection.
Identification of human hyaluronidase-4 as a novel chondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic linkage in the trisulfated tetrasaccharide sequence.
Yamada et al., Sapporo, Japan. In Glycobiology, 2010
Identification of human hyaluronidase-4 as a novel chondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic linkage in the trisulfated tetrasaccharide sequence
Hyaluronidase 3 (HYAL3) knockout mice do not display evidence of hyaluronan accumulation.
Triggs-Raine et al., Winnipeg, Canada. In Matrix Biol, 2008
In humans, six paralogous genes encoding hyaluronidase-like sequences have been identified on human chromosomes 3p21.3 (HYAL2-HYAL1-HYAL3) and 7q31.3 (SPAM1-HYAL4-HYALP1). Mutations in one of these genes, HYAL1, were reported in a patient with mucopolysaccharidosis (MPS) IX.
Expression of hyaluronan synthases and hyaluronidases in the MG63 osteoblast cell line.
Byers et al., Adelaide, Australia. In Matrix Biol, 2006
In mineralising MG63 cells a 62-fold increase in hyaluronidase 2, a 13-fold increase in hyaluronidase 3, and a 3-fold increase in hyaluronidase 4 expression were observed when compared to non-mineralising cells; hyaluronidase 1 and PH20 expression was not detected.
Identification of a hyaluronidase, Hyal5, involved in penetration of mouse sperm through cumulus mass.
Baba et al., Tsukuba, Japan. In Proc Natl Acad Sci U S A, 2006
Hyal5 was exclusively expressed in the testis and formed a 160-kbp gene cluster together with Hyalp1, Hyal4, and Ph-20 on mouse chromosome 6.
Hyaluronidases and CD44 undergo differential modulation during chondrogenesis.
Stern et al., San Francisco, United States. In Biochem Biophys Res Commun, 2002
No expression of HYAL4 and PH-20, the sperm-associated hyaluronidase, was detected.
The six hyaluronidase-like genes in the human and mouse genomes.
Stern et al., San Francisco, United States. In Matrix Biol, 2001
and another two genes (HYAL4 and PH-20/SPAM1) and one expressed pseudogene (HYALP1) are similarly clustered on chromosome 7q31.3.
Human hyaluronidases: electrophoretic multiple forms in somatic tissues and body fluids. Evidence for conserved hyaluronidase potential N-glycosylation sites in different mammalian species.
Zou et al., Orsay, France. In J Biochem Biophys Methods, 2000
A potential N-glycosylation site (site 1) with similar tripeptide patterns was observed at the same position in human plasma (HYAL1), human lysosomes (HYAL2) and in two newly reported hyaluronidases (HYAL4 and HYALP1).
Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31.
Stern et al., Debrecen, Hungary. In Genomics, 1999
The six members of the hyaluronidase family are grouped into two tightly linked triplets on human chromosomes 3p21.3 (HYAL1, HYAL2, and HYAL3) and 7q31.3 (HYAL4, SPAM1 (PH-20), and HYALP1).
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