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HUB1 E3 ubiquitin-protein ligase BRE1-like 1

HUB1, UBL5, ubiquitin-like 5, HISTONE MONOUBIQUITINATION1, rdo4
The gene encodes one of two orthologous E3 ubiquitin ligases in Arabidopsis that are involved in monoubiquitination of histone H2B. (from NCBI)
Top mentioned proteins: Ubiquitin, Histone, ACID, POLYMERASE, CAN
Papers on HUB1
Histone H2B Monoubiquitination Mediated by HISTONE MONOUBIQUITINATION1 and HISTONE MONOUBIQUITINATION2 Is Involved in Anther Development by Regulating Tapetum Degradation-Related Genes in Rice.
Liu et al., Freiburg, Germany. In Plant Physiol, Aug 2015
Here, we report rice (Oryza sativa) HISTONE MONOUBIQUITINATION1 (OsHUB1) and OsHUB2, the homologs of Arabidopsis (Arabidopsis thaliana) HUB1 and HUB2 proteins, which function as E3 ligases in H2Bub1, are involved in late anther development in rice.
Overexpression of ubiquitin-like LpHUB1 gene confers drought tolerance in perennial ryegrass.
Sathish et al., Raleigh, United States. In Plant Biotechnol J, Jun 2015
HUB1, also known as Ubl5, is a member of the subfamily of ubiquitin-like post-translational modifiers.
Ubiquitin-like protein UBL5 promotes the functional integrity of the Fanconi anemia pathway.
Mailand et al., Copenhagen, Denmark. In Embo J, Jun 2015
UBL5 is an atypical UBL that does not form covalent conjugates with cellular proteins and which has a known role in modulating pre-mRNA splicing.
Putative regulatory factors associated with intramuscular fat content.
Coutinho et al., Piracicaba, Brazil. In Plos One, 2014
RIF and PIF analyses identified several candidate genes: GLI2 and IGF2 (RIF1), MPC1 and UBL5 (RIF2) and a host of small RNAs, including miR-1281 (PIF).
OsHUB1 and OsHUB2 interact with SPIN6 and form homo- and hetero-dimers in rice.
Wang et al., Changsha, China. In Plant Signal Behav, 2014
Here, we show that SPIN6 interacts with OsHUB1 and OsHUB2, the homologous proteins of Arabidopsis RING finger E3 ligases HUB1 and HUB2.
UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells.
Mailand et al., Copenhagen, Denmark. In Embo Rep, 2014
As the UBL5 yeast orthologue, Hub1, also promotes spliceosome functions, our results show that UBL5 plays an evolutionary conserved role in pre-mRNA splicing, the integrity of which is essential for the fidelity of chromosome segregation.
Activity of colistin combined with doripenem at clinically relevant concentrations against multidrug-resistant Pseudomonas aeruginosa in an in vitro dynamic biofilm model.
Li et al., Barcelona, Spain. In J Antimicrob Chemother, 2014
METHODS: One colistin-susceptible reference strain (PAO1) and two colistin-susceptible MDR clinical isolates (HUB1 and HUB2; both carbapenem resistant) were investigated over 72 h in the CDC biofilm reactor, a dynamic biofilm model.
Monoubiquitination of histone 2B at the disease resistance gene locus regulates its expression and impacts immune responses in Arabidopsis.
Hua et al., Nanjing, China. In Plant Physiol, 2014
Here, we show that Arabidopsis (Arabidopsis thaliana) E3 ubiquitin ligase genes HISTONE MONOUBIQUITINATION1 (HUB1) and HUB2 regulate the expression of R genes SUPPRESSOR OF npr1-1, CONSTITUTIVE1 (SNC1) and RESISTANCE TO PERONOSPORA PARASITICA4.
Histone H2B monoubiquitination is involved in regulating the dynamics of microtubules during the defense response to Verticillium dahliae toxins in Arabidopsis.
Li et al., Beijing, China. In Plant Physiol, 2014
The loss-of-function alleles of HISTONE MONOUBIQUITINATION1 and HISTONE MONOUBIQUITINATION2 mutations present a weaker depolymerization of the MTs, and protein tyrosine phosphorylation plays a critical role in the regulation of the dynamics of MTs.
Histone H2B monoubiquitination is involved in the regulation of cutin and wax composition in Arabidopsis thaliana.
Shen et al., Strasbourg, France. In Plant Cell Physiol, 2014
Here, using five loss-of-function mutants for histone monoubiquitination, we report on the role of two RING E3 ligases, namely HISTONE MONOUBIQUITINATION 1 and 2 (HUB1 and HUB2), in the selective transcriptional activation of four cuticle biosynthesis genes in Arabidopsis thaliana.
Multiple components of the spliceosome regulate Mcl1 activity in neuroblastoma.
Hogarty et al., Philadelphia, United States. In Cell Death Dis, 2013
Three target genes that shifted the ABT-737 IC50 >1 log were identified and validated: PSMD14, UBL5 and PRPF8.
Porcine ubiquitin-like 5 (UBL5) gene: genomic organization, polymorphisms, mRNA cloning, splicing variants and association study.
Cepica et al., Czech Republic. In Mol Biol Rep, 2013
Ubiquitin-like 5 (UBL5), which is supposed to be involved in regulation of feed intake, energy metabolism, obesity and type 2 diabetes, is located at position 62.1 cM on the pig chromosome 2 region harbouring quantitative trait loci for carcass and meat quality.
Association mapping of quantitative trait loci for carcass and meat quality traits at the central part of chromosome 2 in Italian Large White pigs.
Davoli et al., Czech Republic. In Meat Sci, 2013
A significant QTL for fat deposition (adjusted P=0.0081) and pH1 (adjusted P=0.0972) to MYOD1 at position 44.4 Mb and a QTL for growth and meatiness (adjusted P=0.0238-0.0601) to UBL5 at position 68.9 Mb were mapped.
Human UBL5 protein interacts with coilin and meets the Cajal bodies.
Knejzlík et al., Praha, Czech Republic. In Biochem Biophys Res Commun, 2013
Relation between human UBL5 protein and CBs is in the agreement with current observations about yeast orthologue Hub1 playing important role in alternative splicing.
Purification and characterization of chromium-binding substances from high-chromium yeast.
Uluko et al., Beijing, China. In J Agric Food Chem, 2013
A novel high-molecular-weight chromium-binding substance was also isolated: electrospray ionization tandem mass spectrometry tentatively identified it as HUB1 target protein-1, glyceraldehyde-3-phosphate dehydrogenase, or ribosomal protein L2A(L5A)(rp8)(YL6).
HISTONE MONOUBIQUITINATION1 interacts with a subunit of the mediator complex and regulates defense against necrotrophic fungal pathogens in Arabidopsis.
Mengiste et al., West Lafayette, United States. In Plant Cell, 2009
Results describe the role of the Arabidopsis thaliana RING E3 ligase, HISTONE MONOUBIQUITINATION1 (HUB1) in disease resistance.
Repression of the floral transition via histone H2B monoubiquitination.
He et al., Singapore, Singapore. In Plant J, 2009
HUB1 upregulates the expression of FLC, and interacts with UBC1 and UBC2 to repress flowering.
Identification of sequence variants in the UBL5 (ubiquitin-like 5 or BEACON) gene in obese children by PCR-SSCP: no evidence for association with obesity.
Baroni et al., Cagliari, Italy. In J Pediatr Endocrinol Metab, 2008
The UBL5 gene is unlikely to play a major role in the genetic susceptibility to early-onset obesity.
The absence of histone H2B monoubiquitination in the Arabidopsis hub1 (rdo4) mutant reveals a role for chromatin remodeling in seed dormancy.
Soppe et al., Köln, Germany. In Plant Cell, 2007
role is proposed for chromatin remodeling in seed dormancy by H2B monoubiquitination through HUB1 and HUB2
The Arabidopsis thaliana homolog of yeast BRE1 has a function in cell cycle regulation during early leaf and root growth.
Van Lijsebettens et al., Gent, Belgium. In Plant Cell, 2007
Data show that HUB1 is a functional homolog of the human and yeast BRE1 proteins, adn suggest that it mediates gene activation and cell cycle regulation through chromatin modifications.
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