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HtrA serine peptidase 4

This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: htrA, Omi, CAN, Glide, E14
Papers on HtrA4
Generation and characterization of mice with a conditional null allele of the HtrA4 gene.
Hoh et al., New Haven, United States. In Mol Med Report, Nov 2015
High temperature requirement factor A4 (HtrA4) is a member of the HtrA family of serine peptidases involved in regulating protein‑protein interactions.
Human HtrA4 Expression Is Restricted to the Placenta, Is Significantly Up-Regulated in Early-Onset Preeclampsia, and High Levels of HtrA4 Cause Endothelial Dysfunction.
Nie et al., Australia. In J Clin Endocrinol Metab, Jul 2015
OBJECTIVES: The objectives of the study were to examine serine protease high-temperature requirement factor A4 (HtrA4) expression in the placenta and other human tissues and in early-onset vs late-onset PE, to determine serum HtrA4 levels in normal pregnancy and in PE subtypes, and to investigate the effect of high levels of HtrA4 on endothelial integrity and function.
Functional antagonism between high temperature requirement protein A (HtrA) family members regulates trophoblast invasion.
Chen et al., Taipei, Taiwan. In J Biol Chem, 2014
High temperature requirement A4 (HtrA4) is a secreted serine protease highly expressed in the invasive extravillous trophoblasts that invade decidua.
Activity-modulating monoclonal antibodies to the human serine protease HtrA3 provide novel insights into regulating HtrA proteolytic activities.
Nie et al., Australia. In Plos One, 2013
Since HtrA1, HtrA3 and HtrA4 share identical domain organization, our results establish important foundations for developing potential therapeutics to target these HtrA proteins specifically for the treatment of a number of diseases, including cancer and pregnancy disorders.
Upregulation of HtrA4 in the placentas of patients with severe pre-eclampsia.
Udagawa et al., Japan. In Placenta, 2012
In this study, we characterized HtrA4, a previously uncharacterized HtrA protein family member, in pre-eclampsia.
High-temperature requirement protein A4 (HtrA4) suppresses the fusogenic activity of syncytin-1 and promotes trophoblast invasion.
Chen et al., Taipei, Taiwan. In Mol Cell Biol, 2012
study reveals a novel function of GCM1 and HtrA4 in regulation of trophoblast invasion and that abnormal HrtA4 expression may contribute to shallow trophoblast invasion in preeclampsia
HtrA serine proteases as potential therapeutic targets in cancer.
Baldi et al., Napoli, Italy. In Curr Cancer Drug Targets, 2009
The human HtrA family of serine proteases consists of four members: HtrA1, HtrA2, HtrA3 and HtrA4.
Pattern of expression of HtrA1 during mouse development.
Baldi et al., Napoli, Italy. In J Histochem Cytochem, 2004
The human HtrA family of proteases consists of four members: HtrA1, HtrA2, HtrA3, and HtrA4.
The HtrA family of proteases: implications for protein composition and cell fate.
Ehrmann et al., Martinsried, Germany. In Mol Cell, 2002
FLJ90724 or HTRA4 is a member of the HtrA family of proteases
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