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Taste receptor, type 2, member 43

hTAS2R43, TAS2R43
TAS2R43 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Mar 2009] (from NCBI)
Top mentioned proteins: ACID, hTAS2R44, CAN, hTAS2R46, TAS2R38
Papers on hTAS2R43
A functional comparison of the domestic cat bitter receptors Tas2r38 and Tas2r43 with their human orthologs.
Rawson et al., Saint Charles, United States. In Bmc Neurosci, 2014
RESULTS: We functionally expressed two uncharacterized domestic sequences Tas2r38 and Tas2r43 and deorphanized the receptors using a cellular functional assay.
Association analysis of bitter receptor genes in five isolated populations identifies a significant correlation between TAS2R43 variants and coffee liking.
Gasparini et al., Trieste, Italy. In Plos One, 2013
A significant association was detected with three SNP: one synonymous and two functional variants (W35S and H212R) on the TAS2R43 gene.
Patients with phantogeusia show increased expression of T2R taste receptor genes in their tongues.
Ikeda et al., Tokyo, Japan. In Ann Otol Rhinol Laryngol, 2012
Our results show that the expression rate of some of the T2R taste receptor genes was increased significantly in patients with phantogeusia.
Association of a bitter taste receptor mutation with Balkan Endemic Nephropathy (BEN).
Toncheva et al., Dallas, United States. In Bmc Med Genet, 2011
It has recently been demonstrated that humans are capable of perceiving aristolochic acid at concentrations below 40 nM as the result of high-affinity interactions with the TAS2R43 bitter taste receptor.
Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin.
Rucker et al., Philadelphia, United States. In Plos One, 2010
Probenecid inhibits hTAS2R16, hTAS2R38, and hTAS2R43, but does not inhibit the bitter receptor hTAS2R31 or non-TAS2R GPCRs.
Modulation of bitter taste perception by a small molecule hTAS2R antagonist.
Meyerhof et al., Cincinnati, United States. In Curr Biol, 2010
Surprisingly, we also found that this compound could inhibit five additional hTAS2Rs, including the closely related receptor hTAS2R43.
Structural requirements of bitter taste receptor activation.
Meyerhof et al., Potsdam, Germany. In Proc Natl Acad Sci U S A, 2010
The transfer of functionally relevant amino acids identified in hTAS2R46 to the corresponding positions of hTAS2R43 and -R31 resulted in pharmacological properties indistinguishable from the parental hTAS2R46.
The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin.
Meyerhof et al., Potsdam, Germany. In J Agric Food Chem, 2009
This paper presents the pharmacological characterization of this receptor and analyzes its functional relationship with the previously deorphaned hTAS2R43, hTAS2R44, hTAS2R46, and hTAS2R47.
Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin.
Li et al., San Diego, United States. In Curr Biol, 2007
hT2R43 gene allele makes people more sensitive to the bitterness of an artificial sweetener, saccharin; in addition, a closely related gene's (hT2R44's) allele also makes people more sensitive to the bitterness of saccharin.
Bitter taste receptors for saccharin and acesulfame K.
Meyerhof et al., Potsdam, Germany. In J Neurosci, 2004
hTAS2R43 and hTAS2R44 function as cognate bitter taste receptors and do not contribute to the sweet taste of saccharin and acesulfame K.
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