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Kinesin family member C1

Encodes a cyclin-dependent kinase inhibitor protein that functions as a negative regulator of cell division and promoter of endoreduplication. A member of seven KRP genes found in Arabidopsis thaliana. Differential expression patterns for distinct KRPs were revealed by in situ hybridization. Both SKP2b and RKP appear to be involved in the degradation of KRP1. (from NCBI)
Top mentioned proteins: PCNA, CAN, MHC, HAD, Kip
Papers on HSET
Translating Proteomic Into Functional Data: An High Mobility Group A1 (HMGA1) Proteomic Signature Has Prognostic Value in Breast Cancer.
Sgarra et al., Trieste, Italy. In Mol Cell Proteomics, Jan 2016
qRT-PCR, Western blot, and immunohistochemistry analyses validated the link of three members of this signature (KIFC1, LRRC59, and TRIP13) with HMGA1 expression levels both in vitro and in vivo and wound healing assays demonstrated that these three proteins are involved in modulating tumor cell motility.
Core cell cycle regulatory genes in rice and their expression profiles across the growth zone of the leaf.
Beemster et al., Szeged, Hungary. In J Plant Res, Nov 2015
These cell cycle genes include nine cyclin dependent-kinase (CDK) genes, 27 cyclin genes, one CKS gene, two RBR genes, nine E2F/DP/DEL genes, six KRP genes, and one WEE gene.
The Aspergillus nidulans bimC4 mutation provides an excellent tool for identification of kinesin-14 inhibitors.
Xiang et al., Bethesda, United States. In Fungal Genet Biol, Sep 2015
Human kinesin-14 HSET/KFIC1 is essential for centrosome clustering, and its inhibition leads to the specific killing of cancer cells with extra centrosomes.
The Ran-GTP gradient spatially regulates XCTK2 in the spindle.
Walczak et al., Bloomington, United States. In Curr Biol, Jul 2015
Although many SAFs are non-motile MT-associated proteins, such as NuMA, TPX2, and HURP [7, 10-12], Ran also controls motor proteins, including Kid and HSET/XCTK2 [13, 14].
HSET overexpression fuels tumor progression via centrosome clustering-independent mechanisms in breast cancer patients.
Aneja et al., Atlanta, United States. In Oncotarget, Apr 2015
HSET/KifC1, a kinesin-like minus-end directed microtubule motor has recently found fame as a crucial centrosome clustering molecule.
[mRNA Expression Analysis of 10 Reproduction-related Genes in Different Developmental Proglottids of Moniezia expansa].
Ma et al., In Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi, Feb 2015
According to the results of transcriptome sequencing in Moniezia expansa, 10 functional genes which represent different expression patterns in different developmental proglottids were selected, including KIFC1, Kif17, tgf-beta, SmadD, tgf-beta receptor, HSD5, aminopeptidase puromycin, Methionine aminopeptidase 2, transcription factor fork head and Sox transcription factor.
Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening.
Chen et al., Waltham, United States. In J Med Chem, 2015
KIFC1 (HSET), a member of the kinesin-14 family of motor proteins, plays an essential role in centrosomal bundling in cancer cells, but its function is not required for normal diploid cell division.
Exploitation of the Androgen Receptor to Overcome Taxane Resistance in Advanced Prostate Cancer.
Kyprianou et al., Lexington, United States. In Adv Cancer Res, 2014
Cabazitaxel treatment also leads to downregulation of the microtubule-depolymerizing mitotic kinesins, MCAK, and HSET, preventing their ability to depolymerize microtubules and thus enhancing sensitivity to taxane treatment.
A sensitised RNAi screen reveals a ch-TOG genetic interaction network required for spindle assembly.
Bakal et al., London, United Kingdom. In Sci Rep, 2014
Our genetic screen also reveals that ch-TOG maintains a dynamic microtubule population, in part, through modulating HSET activity.
KIFC1 is a novel potential therapeutic target for breast cancer.
Zhang et al., Birmingham, United States. In Cancer Biol Ther, 2014
Kinesin-like protein KIFC1, a normally nonessential kinesin motor, plays a critical role in centrosome clustering in cancer cells and is essential for the survival of cancer cells.
The dynamics of microtubule minus ends in the human mitotic spindle.
Lüders et al., In Nat Cell Biol, 2014
Poleward movement of γTuRC exceeds k-fibre flux, involves the motors dynein, HSET (also known as KIFC1; a kinesin-14 family member) and Eg5 (also known as KIF11; a kinesin-5 family member), and slows down in pole-proximal regions, resulting in the accumulation of minus ends.
Genetic variations in KIFC1 and the risk of aspirin exacerbated respiratory disease in a Korean population: an association analysis.
Shin et al., Seoul, South Korea. In Mol Biol Rep, 2012
A case-control analysis was carried out by comparing the genotype distribution of six KIFC1 single-nucleotide polymorphisms between 93 aspirin exacerbated respiratory disease cases and 96 aspirin-tolerant asthma controls in a Korean population
Sarcosin (Krp1) in skeletal muscle differentiation: gene expression profiling and knockdown experiments.
Roelen et al., Utrecht, Netherlands. In Int J Dev Biol, 2011
Data show that Sarcosin (Krp1) mRNA is expressed in the myotome part of the mature somites in mouse embryos from embryonic day 9.5 onwards.
BTB-Kelch protein Krp1 regulates proliferation and differentiation of myoblasts.
Pell et al., Cambridge, United Kingdom. In Am J Physiol Cell Physiol, 2011
Data show that both knockdown and overexpression of Krp1 inhibit myoblast differentiation assessed by expression of myogenin, MEF2C, MHC, and cell fusion.
Elucidating the functional role of endoreduplication in tomato fruit development.
Hernould et al., Bordeaux, France. In Ann Bot, 2011
Moreover the fruit-specific functional analysis of the tomato CDK inhibitor KRP1 reveals that cell size and fruit size determination can be uncoupled from DNA ploidy levels, indicating that endoreduplication acts rather as a limiting factor for cell growth.
Novel beta-propeller of the BTB-Kelch protein Krp1 provides a binding site for Lasp-1 that is necessary for pseudopodial extension.
Ozanne et al., Glasgow, United Kingdom. In J Biol Chem, 2009
binding sites necessary for Krp1-Lasp1 interaction in vitro and function in vivo.
The presence of kinesin superfamily motor proteins KIFC1 and KIF17 in normal and pathological human placenta.
Demir et al., Antalya, Turkey. In Placenta, 2009
The intense placental expression of KIFC1 in syncytiotrophoblast and KIF17 in vascular endothelium suggests that both proteins might be important in a cargo-transport system. KIFC1 and KIF17 expression are increased of both in preeclamptia and diabetes.
Chromosome congression in the absence of kinetochore fibres.
Walczak et al., Bloomington, United States. In Nat Cell Biol, 2009
Chromosome congression in HSET + hNuf2 co-depleted cells required the plus-end directed motor CENP-E , which has been implicated in the gliding of mono-oriented kinetochores alongside adjacent K-fibres.
Functions, regulation and cellular localization of plant cyclin-dependent kinase inhibitors.
Fowke et al., Saskatoon, Canada. In J Microsc, 2008
In plants, a family of ICK/KRP CDK inhibitors represented by ICK1 is known and another type of CDK inhibitor represented by the SIMESE (SIM) has recently been reported.
The plant cell cycle--15 years on.
Francis, Cardiff, United Kingdom. In New Phytol, 2006
At G2/M, A-type and the unique B-type CDKs when bound to A, B and D cyclins, drive cells into division; they are negatively regulated by ICK1/2 and perhaps also by WEE1 kinase.
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