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Short chain dehydrogenase/reductase family 16C, member 5

hRDH-E2, epidermal retinal dehydrogenase 2
RDHE2 belongs to a family of short-chain alcohol dehydrogenases/reductases that catalyze the first and rate-limiting step that generates retinaldehyde from retinol (Matsuzaka et al., 2002 [PubMed 12372410]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: ACID, STEP, POLYMERASE, CAN
Papers on hRDH-E2
Biochemical characterization of human epidermal retinol dehydrogenase 2.
Kedishvili et al., Birmingham, United States. In Chem Biol Interact, 2009
The mRNA encoding a putative human enzyme named Epidermal Retinol Dehydrogenase 2 (RDH-E2) was found to be significantly elevated in psoriatic skin [Y.
hRDH-E2 gene polymorphisms, variable transcriptional start sites, and psoriasis.
Inoko et al., Isehara, Japan. In Mamm Genome, 2004
hRDH-E2 is a member of the short-chain alcohol dehydrogenase/reductase (SDR) family that converts retinol to retinaldehyde as the first and rate-limiting step in the retinoic acid synthetic pathway.
Identification of the hRDH-E2 gene, a novel member of the SDR family, and its increased expression in psoriatic lesion.
Inoko et al., Isehara, Japan. In Biochem Biophys Res Commun, 2002
mapped to chromosome 8; may be involved in the pathogenesis of psoriasis through its critical role in retinol metabolism in keratinocyte proliferation
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