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HPN, Hepsin
This gene encodes a type II transmembrane serine protease. The encoded protein has an extracellular region that consists of two domains, a catalytic serine protease domain and a non-catalytic scavenger receptor cysteine-rich domain. This protein may be involved in diverse cellular functions including blood coagulation, maintenance of cell morphology and the growth and progression of certain cancers, particularly prostate cancer. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009] (from NCBI)
Top mentioned proteins: HAD, CAN, AGE, ACID, Serum albumin
Papers on HPN
An improved model of predicting hepatocarcinogenic potential in rats by using gene expression data.
Saito et al., Ōsaka, Japan. In J Appl Toxicol, Feb 2016
The assigned 42 probe sets have included the cancer- or c-Myc-related genes such as Hsp90, Pink1, Hspc111, Fbx29, Hepsin, Syndecan2 and Synbindin.
Maternal Plane of Nutrition During Late-Gestation and Weaning Age Alter Steer Calf Longissimus Muscle Adipogenic MicroRNA and Target Gene Expression.
Loor et al., Urbana, United States. In Lipids, Jan 2016
Early (EW) and normal weaned (NW) Angus × Simmental calves (n = 30) born to cows that were grazing endophyte-infected tall fescue and red clover pastures with no supplement [low plane of nutrition (LPN)], or supplemented with 2.3 and 9.1 kg of dried distiller's grains with solubles and soy hulls [medium and high plane of nutrition (MPN, HPN), respectively] during the last 105 ± 11 days of gestation were used.
The digestive system of 1-week-old Jersey calves is well suited to digest, absorb, and incorporate protein and energy into tissue growth even when calves are fed a high plane of milk replacer.
Ballou et al., Lubbock, United States. In J Dairy Sci, Jan 2016
Twelve Jersey calves were blocked by body weight at birth and randomly assigned to either a high plane of nutrition (HPN) or low plane of nutrition (LPN) treatment.
Safety of home parenteral nutrition during pregnancy.
Singer et al., Tel Aviv-Yafo, Israel. In Clin Nutr, Jan 2016
In this study we examined the use of lipid-based home parenteral nutrition (HPN) in 7 pregnant women, commenced either before or during pregnancy, and their intra-pregnant course as well as a 2-year follow-up of their offspring is described.
Evolution of Helicobacter: Acquisition by Gastric Species of Two Histidine-Rich Proteins Essential for Colonization.
De Reuse et al., Paris, France. In Plos Pathog, Dec 2015
We found that two small paralogous nickel-binding proteins with high content in Histidine (Hpn and Hpn-2) play a central role in maintaining non-toxic intracellular nickel content and in controlling its intracellular trafficking.
SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin.
Luke et al., Pittsburgh, United States. In Biochemistry, Dec 2015
SERPINB12 also inhibited Hepsin.
Aconitase Functions as a Pleiotropic Posttranscriptional Regulator in Helicobacter pylori.
Maier et al., Athens, United States. In J Bacteriol, Oct 2015
A bioinformatics prediction tool was used to identify putative targets for aconitase-mediated regulation, and electrophoretic mobility shift assays demonstrated that apo-AcnB is able to bind to RNA transcripts of hpn (encoding a nickel-sequestering protein), ahpC (encoding alkyl hydroperoxide reductase), and flgR (encoding flagellum response regulator).
Marine Bromophenol Derivative 3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-isopropoxymethyl benzyl)benzene-1,2-diol Protects Hepatocytes from Lipid-Induced Cell Damage and Insulin Resistance via PTP1B Inhibition.
Shi et al., Qingdao, China. In Mar Drugs, Jul 2015
3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-isopropoxymethyl benzyl)benzene-1,2-diol (HPN) is a bromophenol derivative from the marine red alga Rhodomela confervoides.
Reverse phase protein arrays in signaling pathways: a data integration perspective.
Huang et al., Houston, United States. In Drug Des Devel Ther, 2014
There also exists a clear need for effective visualization approaches to RPPA-based proteomic results; this was highlighted by the recent challenge, put forth by the HPN-DREAM consortium, to develop visualization methods for a highly complex RPPA dataset involving many cancer cell lines, stimuli, and inhibitors applied over time course.
Feasibility of investigating differential proteomic expression in depression: implications for biomarker development in mood disorders.
Biernacka et al., Rochester, United States. In Transl Psychiatry, 2014
After correcting for multiple testing and adjusting for covariates, growth differentiation factor 15 (GDF-15), hemopexin (HPX), hepsin (HPN), matrix metalloproteinase-7 (MMP-7), retinol-binding protein 4 (RBP-4) and transthyretin (TTR) all showed statistically significant differences among groups.
Prostate cancer invasion and metastasis: insights from mining genomic data.
Loots et al., Livermore, United States. In Brief Funct Genomics, 2013
Promising molecular markers identified from gene expression profiling studies include HPN, CLU1, WT1, WNT5A, AURKA and SPARC.
Epidemiology of catheter-related infections in adult patients receiving home parenteral nutrition: a systematic review.
Willems et al., Leuven, Belgium. In Clin Nutr, 2013
BACKGROUND AND AIMS: Catheter-related infection (CRI) is the most common and serious complication for adult patients receiving home parenteral nutrition (HPN).
Mechanisms and treatment of blast induced hearing loss.
Choi, Kyŏngsan, South Korea. In Korean J Audiol, 2012
The pharmacological approaches to block or inhibit some of the auditory pathological consequences caused by blast exposure have been developed with antioxidant drugs such as 2,4-disulfonyl α-phenyl tertiary butyl nitrone (HXY-059, now called HPN-07) and N-acetylcysteine (NAC).
Identification of hepsin and protein disulfide isomerase A3 as targets of gelatinolytic action in rat ovarian granulosa cells during the periovulatory period.
Curry et al., Lexington, United States. In Biol Reprod, 2011
Results suggest that hepsin and PDIA3 undergo proteolysis by MMP2/9 in ovarian granulosa cells during ovulation and/or luteinization.
Proteolytic activation of pro-macrophage-stimulating protein by hepsin.
Kirchhofer et al., San Francisco, United States. In Mol Cancer Res, 2011
These findings suggest that the MSP/RON signaling pathway may be regulated by hepsin in tissue homeostasis and in disease pathologies, such as in cancer and immune disorders.
Matrix-dependent regulation of AKT in Hepsin-overexpressing PC3 prostate cancer cells.
Wittig et al., Heidelberg, Germany. In Neoplasia, 2011
Elevated levels of hepsin interfere with cell adhesion and viability in the background of prostate cancer as well as other tissue types, the details of which depend on the microenvironment provided.
Clinical and biological significance of hepsin overexpression in breast cancer.
Wei et al., Shenyang, China. In J Investig Med, 2011
hepsin expression is frequently up-regulated in breast cancer tissues, which is associated with tumor growth and progression
Isolation, purification, and study of properties of recombinant hepsin from Escherichia coli.
Severin et al., Moscow, Russia. In Biochemistry (mosc), 2010
Hepsin activity was inhibited by anthralin and increased by resveratrol.
Nickel-binding and accessory proteins facilitating Ni-enzyme maturation in Helicobacter pylori.
Seshadri et al., Athens, United States. In Biometals, 2007
The His-rich putative nickel storage proteins Hpn and Hpn-like play roles in nickel detoxification and may influence the levels of Ni-activated urease that can be achieved.
Bioinorganic chemistry of bismuth and antimony: target sites of metallodrugs.
Sun et al., Hong Kong, Hong Kong. In Acc Chem Res, 2007
Structures of bismuth antiulcer agents and interactions of Bi3+ with proteins and enzymes, such as transferrin and lactoferrin, the histidine-rich protein Hpn, and urease, have been characterized.
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