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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Defensin, alpha 4, corticostatin

HP4, corticostatin, HNP-4, DEFA4
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Defensin, Haptoglobin, ACID, HNP, CAN
Papers on HP4
Novel genes and variants associated with IgA nephropathy by co-segregating with the disease phenotypes in 10 IgAN families.
Wang et al., Guangzhou, China. In Gene, Nov 2015
MYCT1 p.Asp22Glufs*34 was associated with IgAN by co-segregating with its phenotypes in families 2, 7, and 9; DEFA4 p.Ala8Pro, p.Ala8Val, c.172+1G>T co-segregated in families 1, 2, and 3; ZNF543 p.Pro226Ala co-segregated in families 3, 5, and 6 and CARD8 p.Val98Lysfs*26 co-segregated in families 7 and 8.
Is it appropriate to use fixed assay cut-offs for estimating seroprevalence?
Farrington et al., London, United Kingdom. In Epidemiol Infect, Sep 2015
A time-resolved fluorescence immunoassay (TRFIA) was used to test exposure to human parvovirus 4 (HP4).
Decreased Expression of Innate Immunity-Related Genes in Peripheral Blood Mononuclear Cells from Patients with IgG4-Related Disease.
Umehara et al., Kanazawa, Japan. In Plos One, 2014
Steroid therapy significantly increased the expression of DEFA3, DEFA4 and MS4A3, but had no effect on the expression of CLC, IL8RA and IL8RB.
Oviduct-specific expression of human neutrophil defensin 4 in lentivirally generated transgenic chickens.
Hu et al., Beijing, China. In Plos One, 2014
In this study, we constructed a lentiviral vector encoding an expression cassette for human neutrophil defensin 4 (HNP4), a compound that displays high activity against Escherichia coli, and produced transgenic chickens that expressed the recombinant HNP4 protein in egg whites.
Urinary proteins, vitamin D and genetic polymorphisms as risk factors for febrile urinary tract infection and relation with bacteremia: a case control study.
van de Vosse et al., Leiden, Netherlands. In Plos One, 2014
In 440 controls and 707 UTI patients polymorphisms were genotyped in the genes CXCR1, DEFA4, DEFB1, IL6, IL8, MYD88, UMOD, TIRAP, TLR1, TLR2, TLR5 and TNF.
Effect of different head and neck positions on behaviour, heart rate variability and cortisol levels in lunged Royal Dutch Sport horses.
van der Kolk et al., Utrecht, Netherlands. In Vet J, 2014
To evaluate the effect on welfare, seven Royal Dutch Sport horses were studied in five predetermined HNPs: (1) unrestrained (HNP1); (2) neck raised, bridge of nose around the vertical (HNP2); (3) neck lowered and considerably flexed, bridge of nose pointing towards the chest (HNP4); (4) neck raised and extended, bridge of nose in front of the vertical (HNP5), and (5) neck lowered and flexed, bridge of nose pointing towards the carpus (HNP7).
Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation.
Libert et al., Gent, Belgium. In Mucosal Immunol, 2014
Interestingly, we found that different α-defensins, namely Crp1 (DEFA1) and Crp4 (DEFA4), can stimulate IL-6 release in macrophages and ileum explants in a TLR4 independent way.
Gender differences of B cell signature in healthy subjects underlie disparities in incidence and course of SLE related to estrogen.
Hou et al., Nanjing, China. In J Immunol Res, 2013
Except for the 5 Y-chromosome-related genes or varients, only 3 DEGs (LTF, CAMP, and DEFA4) were selected and qRT-PCR confirmed that the expressions of LTF and CAMP decreased significantly in B cells from female SLE patients.
Transcriptional profiling of whole blood identifies a unique 5-gene signature for myelofibrosis and imminent myelofibrosis transformation.
Kruse et al., Roskilde, Denmark. In Plos One, 2013
Amongst the top-20 of the most upregulated genes in PMF compared to controls, we identified 5 genes (DEFA4, ELA2, OLFM4, CTSG, and AZU1), which were highly significantly deregulated in PMF only.
Differences and similarities in the transcriptional profile of peripheral whole blood in early and late-onset preeclampsia: insights into the molecular basis of the phenotype of preeclampsiaa.
Hassan et al., Wayne, United States. In J Perinat Med, 2013
Thirteen genes that encode proteins involved in host defense (DEFA4, BPI, CTSG, LCN2), tight junctions in blood-brain barrier (EMP1) and liver regeneration (ECT2) were differentially expressed in both early- and late-onset PE.
Prediction of response to treatment by gene expression profiling of peripheral blood in patients with microscopic polyangiitis.
JMAAV et al., Sapporo, Japan. In Plos One, 2012
This preliminary study identified IRF7, IFIT1, IFIT5, OASL, CLC, GBP-1, PSMB9, HERC5, CCR1, CD36, MS4A4A, BIRC4BP, PLSCR1, DEFA1/DEFA3, DEFA4, and COL9A2 as the important genes that can predict the response to the treatment in patients with MPA at an early point during the therapy.
Protamine 2 precursors and processing.
Oliva et al., Barcelona, Spain. In Protein Pept Lett, 2011
Protamine 2 (P2) is synthesised as a precursor protein (pre-P2) which by proteolysis is processed to generate the mature components of the protamine 2 family of proteins (HP2, HP3 and HP4).
α-defensin 1-3 and α-defensin 4 as predictive markers of imatinib resistance and relapse in CML patients.
Turcq et al., Bordeaux, France. In Dis Markers, 2010
DEFA1-3 and DEFA4 mRNA level in peripheral blood cells can be used to identify chronic myeloid leukaemia patients who are at risk of being imatinib-resistant, before initiation of the therapy.
Gene expression of oncogenes, antimicrobial peptides, and cytokines in the development of oral leukoplakia.
Winter et al., Bonn, Germany. In Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2010
The combination of an increased expression of the antimicrobial peptide DEFA-4, the oncogene S100-A7, epidermal growth factor, and tenascin-c, and a decreased Doc-1 expression in oral leukoplakia might characterize its potency of malignant transformation.
Gene expression profiles of acute exacerbations of idiopathic pulmonary fibrosis.
Kaminski et al., Pittsburgh, United States. In Am J Respir Crit Care Med, 2009
DEFA4 was upregulated in IPF patients with acute exacerbation
Neutrophil-derived defensins as modulators of innate immune function.
Hancock et al., Vancouver, Canada. In Crit Rev Immunol, 2007
Human neutrophils contain large amounts of the cationic alpha-defensin peptides, HNP-1-3, as well as HNP-4, which is present in lower amounts, while two Paneth cell alpha-defensins, HD-5 and HD-6, are also found in the gut.
Multispecific myeloid defensins.
Lehrer, Los Angeles, United States. In Curr Opin Hematol, 2007
Human neutrophils contain large amounts of three alpha-defensins (HNP-1-HNP-3), and smaller amounts of a fourth, HNP-4.
Crystal structures of human alpha-defensins HNP4, HD5, and HD6.
Lubkowski et al., Frederick, United States. In Protein Sci, 2006
Crystal structure of HNP-4.
Drug and xenobiotic glucuronidation catalysed by cloned human liver UDP-Glucuronosyltransferases stably expressed in tissue culture cell lines.
Burchell et al., United Kingdom. In Toxicology, 1993
UGT HP1 exhibited a limited specificity for planar phenolic compounds, whereas UGT HP4 was more promiscuous in acceptance of non-planar phenols, anthraquinones, flavones, aliphatic alcohols, aromatic carboxylic acids, steroids and many drugs of varied structure.
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