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Homeobox D3

HOXD3, Hox-4.1
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Hoxd4, Hoxa3, POLYMERASE, HOXA9
Papers on HOXD3
Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk.
Pharoah et al., Cambridge, United Kingdom. In Cancer Epidemiol Biomarkers Prev, Oct 2015
RESULTS: Gene set enrichment analysis identified six networks centered on TF genes (HOXB2, HOXB5, HOXB6, HOXB7 at 17q21.32 and HOXD1, HOXD3 at 2q31) that were significantly enriched for genes from the risk-associated end of the ranked list (P < 0.05 and FDR < 0.05).
Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.
Eriksson et al., Mountain View, United States. In Hum Mol Genet, Jun 2015
Cyclin D1b splice variant promotes αvβ3-mediated adhesion and invasive migration of breast cancer cells.
Feng et al., Wuhan, China. In Cancer Lett, 2015
Specifically, cyclin D1b is found to modulate the expression of αvβ3, which characterizes the metastatic phenotype, and enhance tumor cell invasive potential in cooperating with HoxD3.
Novel candidate key drivers in the integrative network of genes, microRNAs, methylations, and copy number variations in squamous cell lung carcinoma.
Cai et al., Shanghai, China. In Biomed Res Int, 2014
The novel candidate key drivers in this refined subnetwork, such as the methylation of ARHGDIB and HOXD3, microRNA let-7a and miR-31, and the CNV of AGAP2, were identified and analyzed.
Methylation of PITX2, HOXD3, RASSF1 and TDRD1 predicts biochemical recurrence in high-risk prostate cancer.
Bollen et al., Leuven, Belgium. In J Cancer Res Clin Oncol, 2014
PURPOSE: To explore differential methylation of HAAO, HOXD3, LGALS3, PITX2, RASSF1 and TDRD1 as a molecular tool to predict biochemical recurrence (BCR) in patients with high-risk prostate cancer (PCa).
Validation study of genes with hypermethylated promoter regions associated with prostate cancer recurrence.
Stanford et al., Seattle, United States. In Cancer Epidemiol Biomarkers Prev, 2014
Significant promoter hypermethylation in at least 50% of CpG sites in two genes, ABHD9 and HOXD3, was found in tumors from patients who recurred compared with those without recurrence.
Correlation of HOXD3 promoter hypermethylation with clinical and pathologic features in screening prostate biopsies.
Suy et al., In Prostate, 2014
BACKGROUND: Molecular markers that can discriminate indolent cancers from aggressive ones may improve the management of prostate cancer and minimize unnecessary treatment.Aberrant DNA methylation is a common epigenetic event in cancers and HOXD3 promoter hypermethylation (H3PH) has been found in prostate cancer.
The absence of mutations in homeobox candidate genes HOXA3, HOXB3, HOXD3 and PITX2 in familial and sporadic thyroid hemiagenesis.
Maciel et al., In J Pediatr Endocrinol Metab, 2014
OBJECTIVE: The aim of this work was to search for mutations in thyroid developmental candidate genes HOXA3, HOXB3, HOXD3 and PITX2.
Novel multiplex MethyLight protocol for detection of DNA methylation in patient tissues and bodily fluids.
Bapat et al., Toronto, Canada. In Sci Rep, 2013
Herein, we developed, optimized and standardized a multiplex MethyLight assay to simultaneously detect hypermethylation of APC, HOXD3 and TGFB2 in DNA extracted from prostate cancer (PCa) cell lines, archival tissue specimens, and urine samples.
Transcript analysis reveals a specific HOX signature associated with positional identity of human endothelial cells.
Morrell et al., Cambridge, United Kingdom. In Plos One, 2013
For example, this included a cluster on chromosome 2 of HOXD1, HOXD3, HOXD4, HOXD8 and HOXD9 that was expressed at a higher level in BOECs.
Expression of HOXD3 correlates with shorter survival in patients with invasive breast cancer.
Qingyuan et al., Harbin, China. In Clin Exp Metastasis, 2013
The HOXD3 gene, a member of the Hox gene family, has been demonstrated to be expressed in several tumor cell lines, which exhibit enhanced invasion and metastasis through coordinate expression of metastasis-associated factors.
Methylation alterations of WT1 and homeobox genes in inflamed muscle biopsy samples from patients with untreated juvenile dermatomyositis suggest self-renewal capacity.
Pachman et al., Chicago, United States. In Arthritis Rheum, 2012
Six homeobox genes were among them; ALX4, HOXC11, HOXD3, and HOXD4 were hypomethylated, while EMX2 and HOXB1 were hypermethylated.
Functional dissection of HOXD cluster genes in regulation of neuroblastoma cell proliferation and differentiation.
Ding et al., Augusta, United States. In Plos One, 2011
The HOXD cluster contains nine genes (HOXD1, HOXD3, HOXD4, and HOXD8-13) that are positioned sequentially from 3' to 5', with HOXD1 at the 3' end and HOXD13 the 5' end.
DNA hypomethylation affects cancer-related biological functions and genes relevant in neuroblastoma pathogenesis.
Lavarino et al., Barcelona, Spain. In Plos One, 2011
Hypermethylation targeted genes involved in cell development and proliferation such as RASSF1A, POU2F2 or HOXD3, among others.
Association of tissue promoter methylation levels of APC, TGFβ2, HOXD3 and RASSF1A with prostate cancer progression.
Bapat et al., Toronto, Canada. In Int J Cancer, 2011
quantitative increase in promoter methylation levels of HOXD3 is associated with prostate cancer progression
DNA methylation of HOXD3 as a marker of prostate cancer progression.
Bapat et al., Toronto, Canada. In Lab Invest, 2010
HOXD3 methylation distinguishes low-grade prostate cancers from intermediate and high-grade ones.
Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarrays.
Bapat et al., Toronto, Canada. In Plos One, 2008
Further validation of candidate genes on a separate cohort of low and high grade prostate cancers by quantitative MethyLight analysis has allowed us to confirm DNA hypermethylation of HOXD3 and BMP7...
Homeobox genes Hoxd3 and Hoxd8 are differentially expressed in fetal mouse excisional wounds.
Lanning et al., Richmond, United States. In J Surg Res, 2008
These data suggest that Hoxd3 is constitutively expressed in the skin of mid-gestational mice
Inactivation of HOXA genes by hypermethylation in myeloid and lymphoid malignancy is frequent and associated with poor prognosis.
Brown et al., Newcastle upon Tyne, United Kingdom. In Clin Cancer Res, 2007
Study identified hypermethylation and gene inactivation of HOXA4 and HOXA5 was frequently observed (26-79%) in all types of leukemias studied.
Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions.
Capecchi et al., Salt Lake City, United States. In Nature, 1994
We showed previously that mice homozygous for independent targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 had no defects in common.
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