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Homeobox D11
Hoxd11, Hox-4.6
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. [provided by RefSeq, Jul 2008] (from
NCBI)
Sponsored links
Top mentioned proteins:
SP-D, Hoxd12, HOX11, HOXA9, POLYMERASE
Papers using
Hoxd11
antibodies
Phylogenies and the analysis of evolutionary sequences, with examples from seed plants.
Supplier
In PLoS ONE, 1988
... HoxD-11 geneDNA extractions were performed on alligator embryo samples preserved in 95% ethanol using the DNAEasy Tissue kit (Qiagen inc) according to the ...
Papers on
Hoxd11
Identification of genomic aberrations in hemangioblastoma by droplet digital PCR and SNP microarray highlights novel candidate genes and pathways for pathogenesis.
New
Tel Aviv-Yafo, Israel. In Bmc Genomics, Dec 2015
CONCLUSIONS: Our findings provide the first high-resolution genome-wide view of chromosomal changes in hemangioblastoma and identify 23 candidate genes: EGFR, PRDM16, PTPN11, HOXD11, HOXD13, FLT3, PTCH, FGFR1, FOXP1, GPC3, HOXC13, HOXC11, MKL1, CHEK2, IRF4, GPHN, IKZF1, RB1, HOXA9, and micro RNA, such as hsa-mir-196a-2 for hemangioblastoma pathogenesis.
An EG-VEGF-dependent decrease in homeobox gene NKX3.1 contributes to cytotrophoblast dysfunction: a possible mechanism in human fetal growth restriction.
New
Melbourne, Australia. In Mol Med, Aug 2015
The Homeobox gene array identified a >5-fold increase in HOXA9, HOXC8, HOXC10, HOXD1, HOXD8, HOXD9 and HOXD11, while NKX 3.1 showed a >2 fold-decrease in mRNA expression compared to untreated controls.
Overexpression of HOX genes is prevalent in Ewing sarcoma and is associated with altered epigenetic regulation of developmental transcription programs.
Ann Arbor, United States. In Epigenetics, 2014
Specifically, ES and EWS-FLI1+ stem cells displayed a relative loss of polycomb-dependent H3K27me3 and gain of trithorax-dependent H3K4me3 at the promoters of posterior HOXD genes and also at the HOXD11.12
POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in head and neck cancer.
Belfast, United Kingdom. In Oncotarget, 2014
Knockdown of HOXD10 in HNSCC cells caused decreased proliferation and invasion, whereas knockdown of HOXD11 reduced only invasion.
Differentiation of human pluripotent stem cells into nephron progenitor cells in a serum and feeder free system.
Taejŏn, South Korea. In Plos One, 2013
RESULTS: After modification of culture period and concentration of exogenous factors, hPSCs can differentiate into NPCs that markedly express specific marker genes such as SIX2, GDNF, HOXD11, WT1 and CITED1 in addition to OSR1, PAX2, SALL1 and EYA1.
Salamander Hox clusters contain repetitive DNA and expanded non-coding regions: a typical Hox structure for non-mammalian tetrapod vertebrates?
Lexington, United States. In Hum Genomics, 2012
In particular, the distance between hoxd13 and hoxd11 is longer in newt than orthologous regions from vertebrate species with expanded Hox clusters and is predicted to exceed the length of the entire HoxD clusters (hoxd13-hoxd4) of humans, mice, and frogs.
Genome-wide DNA methylation profiling of CpG islands in hypospadias.
San Francisco, United States. In J Urol, 2012
These CpG sites were in or near the SCARB1, MYBPH, SORBS1, LAMA4, HOXD11, MYO1D, EGFL7, C10orf41, LMAN1L and SULF1 genes.
Homeobox gene expression profile indicates HOXA5 as a candidate prognostic marker in oral squamous cell carcinoma.
São Paulo, Brazil. In Int J Oncol, 2012
After qRT-PCR assays, the three most up-regulated homeobox genes (HOXA5, HOXD10 and HOXD11) revealed higher and statistically significant expression levels in OSCC samples when compared to margins.
Functional dissection of HOXD cluster genes in regulation of neuroblastoma cell proliferation and differentiation.
Augusta, United States. In Plos One, 2011
However, induction of other HOXD genes either has no effect (HOXD1) or has partial effects (HOXD3, HOXD4, HOXD11 and HOXD13) on BE(2)-C cell proliferation or differentiation.
Hox11 genes establish synovial joint organization and phylogenetic characteristics in developing mouse zeugopod skeletal elements.
GeneRIF
Philadelphia, United States. In Development, 2010
Hox11 genes (Hoxa11, Hoxc11 and Hoxd11) co-regulate and coordinate the development of zeugopod skeletal elements and adjacent elbow and knee joints, and dictate joint identity, morphogenesis and anatomical and functional organization.
Hox gene expression in the embryonic genital system of the sea turtle Lepidochelys olivacea (Eschscholt, 1829), a species with temperature-dependent sex determination.
Mazatlán, Mexico. In Gene Expr Patterns, 2010
For the first time, we examined the quantitative and spatial expression of two Hox 5' genes, HoxD11 and HoxA13, in the developing genital system of the olive ridley Lepidochelys olivacea, a species with temperature-dependent sex determination.
Study of HOXD genes in autism particularly regarding the ratio of second to fourth digit length.
GeneRIF
Hamamatsu, Japan. In Brain Dev, 2010
data show no significant difference in HOXD11, HOXD12 & HOXD13 genotype frequencies between the autism spectrum disorder & healthy controls, but one SNP in promoter region of HOXD11 was observed in only 4 patients with ASD
A region of the human HOXD cluster that confers polycomb-group responsiveness.
Impact
GeneRIF
Boston, United States. In Cell, 2010
In human embryonic stem cell (hESCs)differentiation, a 1.8kb region between HOXD11 and HOXD12 (D11.12) that is associated with PcG proteins was discovered, it shows alteration in nuclease sensitivity as hESCs differentiate.
HOXD13 binds DNA replication origins to promote origin licensing and is inhibited by geminin.
Modena, Italy. In Mol Cell Biol, 2009
We show that HOXD13, HOXD11, and HOXA13 bind in vivo all characterized human replication origins tested.
Absence of mutations in the HOXA11 and HOXD11 genes in children with congenital renal malformations.
GeneRIF
Ioánnina, Greece. In Pediatr Nephrol, 2009
Our findings do not support the hypothesis that mutations in the HOXD11 coding regions are involved in the pathogenesis of human non-syndromal congenital renal parenchymal malformations.
Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo.
GeneRIF
Cambridge, United States. In Dev Biol, 2008
Mice lacking all Hox11 activity fail to form metanephric kidney structures; when Hoxd11 is ectopically activated in the anterior mesonephros, we observe a partial transformation to a metanephric program of development.
Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13).
Review
Lund, Sweden. In Genes Chromosomes Cancer, 2003
The NUP98 gene at 11p15 is known to be fused to DDX10, HOXA9, HOXA11, HOXA13, HOXD11, HOXD13, LEDGF, NSD1, NSD3, PMX1, RAP1GDS1, and TOP1 in various hematologic malignancies.
Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11.
Impact
GeneRIF
Salt Lake City, United States. In Nature, 1995
mice mutant for Hoxd11 and Hoxa11 show absence of radius and ulna, anterior homeotic transformation of vertebra, and severe kidney defects, suggesting Hoxd11 and Hoxa11 act together to specify limb outgrowth and patterning of proximodistal axis
Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations.
Impact
Boston, United States. In Nature, 1992
Here we test this hypothesis directly using replication-competent retroviral vectors to expand the domain of expression of the Hox-4.6 gene anteriorly during limb development in vivo.
