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Homeobox C5

HOXC5, Hox-3.4, HOX3D
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC5, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants have been described for HOXC5. The transcript variant which includes the shared exon apparently doesn't encode a protein. The protein-coding transcript variant contains gene-specific exons only. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HOXC6, HOXC4, Hoxd4, Hoxa5, Hoxc8
Papers on HOXC5
Putative regulatory factors associated with intramuscular fat content.
Coutinho et al., Piracicaba, Brazil. In Plos One, 2014
Candidate genes identified by PCIT include: ANKRD26, HOXC5 and PPAPDC2.
The Hox cluster microRNA miR-615: a case study of intronic microRNA evolution.
Holland et al., Oxford, United Kingdom. In Evodevo, 2014
Within the Hox gene clusters, a miRNA gene, miR-615, is located within the intron of the Hoxc5 gene.
Homeobox C5 expression is associated with the progression of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Yoon et al., Kwangju, South Korea. In J Oral Pathol Med, 2012
The present study investigated the expression of HOXC5 in OSCC and identified molecular biomarker whose expression is associated with the multistep oral carcinogenesis.
Distinct roles for Wnt-4 and Wnt-11 during retinoic acid-induced neuronal differentiation.
Kypta et al., Spain. In Stem Cells, 2011
Gene silencing of Wnt-4, but not Wnt-11, reduced retinoic acid downregulation of OCT4 and Nanog and upregulation of PAX6, ASCL1, HOXC5, and NEUROD1, suggesting that Wnt-4 promotes early neuronal differentiation.
Differential gene expression in benign prostate epithelium of men with and without prostate cancer: evidence for a prostate cancer field effect.
Lin et al., Seattle, United States. In Clin Cancer Res, 2010
Expression of other prostate cancer-associated genes, including ERG, HOXC4, HOXC5, and MME, were also increased in CABE by quantitative reverse transcription-PCR, although other genes commonly altered in prostate cancer were not different between the BABE and CABE samples.
[Expression of 39 HOX genes in esophageal cancer cell lines].
Chen et al., Beijing, China. In Zhonghua Wei Chang Wai Ke Za Zhi, 2007
They were HOXA2, HOXA7, HOXA9, HOXA10, HOXA13, HOXB7, HOXB9, HOXC4, HOXC5, HOXC6, HOXC8, HOXC9, HOXD9, HOXD10, and HOXD13 respectively.
Role of Bmi1 in H2A ubiquitylation and Hox gene silencing.
Wang et al., Birmingham, United States. In J Biol Chem, 2006
Additionally, we demonstrated that the HoxC5 gene is regulated by ubiquitylated H2A in HeLa cells and that ubiquitylated H2A is localized on 5' regulatory regions of the HoxC5 gene.
Suppression of invasive characteristics by antisense introduction of overexpressed HOX genes in ovarian cancer cells.
Ishikawa et al., Asahikawa, Japan. In Int J Oncol, 2006
Real-time quantitative RT-PCR assay indicated overexpression of 14 HOX genes in clusters A and B but only 2 genes in clusters C and D. Of the 16 HOX genes, overexpression of paralogs of HOX3, HOX4 and HOX7 is seen in cluster A and B, and of HOX13 in all paralogs.
Analysis of single nucleotide polymorphisms and haplotypes in HOXC gene cluster within susceptible region 12q13 of simple congenital heart disease.
Sun et al., Shenyang, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2005
The A17860G located in 3'flanking sequence of HOXC5 gene is associated with simple congenital heart disease; the haplotype of 3 SNPs may be linked with the susceptible gene of simple CHD.
Aberrant expression of HOX genes in human invasive breast carcinoma.
Moriuchi et al., Sapporo, Japan. In Oncol Rep, 2005
Comparing expression levels of each HOX gene among the different types of cancer tissues, the expression level of HOXB7 was lower in lymph node metastasis-positive cancer tissues than negative cancer tissues; those of HOXD12 and D13 were higher in progesterone receptor-positive cancer tissues than negative cancer tissues; and the expression level of HOXC5 was lower in cancerous tissues with mutated-type p53 than in normal and cancerous tissues with wild-type p53.
Aberrant HOXC expression accompanies the malignant phenotype in human prostate.
Nordeen et al., Denver, United States. In Cancer Res, 2003
Specific reverse transcription-PCR for HOXC4, HOXC5, HOXC6, and HOXC8 confirmed overexpression of these genes in malignant cell lines and lymph node metastases.
Defects in cervical vertebrae in boric acid-exposed rat embryos are associated with anterior shifts of hox gene expression domains.
Gofflot et al., Brussels, Belgium. In Birth Defects Res A Clin Mol Teratol, 2003
We observed no difference between control and treated embryos in the location of the cranial limit of expression of the other genes: hoxd4, hoxa4, hoxc5, and hoxa5.
HOXC5 and HOXC8 expression are selectively turned on in human cervical cancer cells compared to normal keratinocytes.
Clausse et al., Li├Ęge, Belgium. In Biochem Biophys Res Commun, 1999
Only HOXA2, HOXA7, HOXC5, HOXC8 and HOXD12 were found to be silent.
Differentiation and cell-type-restricted expression of HOXC4, HOXC5 and HOXC6 in myeloid leukemias and normal myeloid cells.
Meijer et al., Amsterdam, Netherlands. In Leukemia, 1998
Recently, we have demonstrated that HOXC4 and HOXC6, but not HOXC5, are expressed during lymphoid differentiation.
HOXC4, HOXC5, and HOXC6 expression in non-Hodgkin's lymphoma: preferential expression of the HOXC5 gene in primary cutaneous anaplastic T-cell and oro-gastrointestinal tract mucosa-associated B-cell lymphomas.
Meijer et al., Amsterdam, Netherlands. In Blood, 1997
In contrast, HOXC5 is not expressed in the lymphoid lineage, but was found in lymphoid cell lines, representing the neoplastic equivalents of various differentiation stages of T and B lymphocytes.
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