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Homeobox C4

HOXC4, Hox3.5
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HOXC6, CAN, HOXC5, POLYMERASE, ACID
Papers on HOXC4
Estrogen receptor signal in regulation of B cell activation during diverse immune responses.
Dasgupta et al., Vũng Tàu, Vietnam. In Int J Biochem Cell Biol, Nov 2015
The mode of signalling action of this single chain nuclear receptor protein molecule depends on its ability to bind to the promoters of Pax5, HOXC4 and apolipoprotein B RNA-editing enzyme activation-induced cytidine deaminase (AID) genes.
Identification of a Candidate Gene Panel for the Early Diagnosis of Prostate Cancer.
Schalken et al., Nijmegen, Netherlands. In Clin Cancer Res, Aug 2015
After quantitative PCR analysis on tissue specimens and urinary sediments, eight promising biomarkers for the urinary detection of prostate cancer were selected (ONECUT2, HOXC4, HOXC6, DLX1, TDRD1, NKAIN1, MS4A8B, PPFIA2).
Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody responses.
Casali et al., Irvine, United States. In J Immunol, 2015
The selectivity of histone deacetylase inhibitor-mediated silencing of AICDA/Aicda and PRDM1/Prdm1 was emphasized by unchanged expression of HoxC4 and Irf4 (important inducers/modulators of AICDA/Aicda), Rev1 and Ung (central elements for CSR/SHM), and Bcl6, Bach2, or Pax5 (repressors of PRDM1/Prdm1 expression), as well as unchanged expression of miR-19a/b, miR-20a, and miR-25, which are not known to regulate AICDA/Aicda or PRDM1/Prdm1.
Differential DNA Methylation in Relation to Age and Health Risks of Obesity.
Martínez et al., Pamplona, Spain. In Int J Mol Sci, 2014
In addition, DNA methylation of three CpG sites located in ELOVL2; HOXC4 and PI4KB were further negatively associated with their mRNA levels.
Transcriptional profiling predicts overwhelming homology of Schwann cells, olfactory ensheathing cells, and Schwann cell-like glia.
Baumgärtner et al., Hannover, Germany. In Glia, 2014
Differentially expressed genes possibly involved in the maintenance of cell type-specific identity included an up-regulation of HOXD8 and HOXC4 in SCs, and an up-regulation of CNTNAP2 and EFEMP1 in OECs/SG.
Adult human neural crest-derived cells for articular cartilage repair.
Martin et al., Basel, Switzerland. In Sci Transl Med, 2014
Using hyaline cartilage as a model, we showed that adult human neuroectoderm-derived nasal chondrocytes (NCs) can be constitutively distinguished from mesoderm-derived articular chondrocytes (ACs) by lack of expression of specific HOX genes, including HOXC4 and HOXD8.
[Expression of HOXC4 gene during early development in zebrafish].
Li et al., Guiyang, China. In Sichuan Da Xue Xue Bao Yi Xue Ban, 2013
OBJECTIVE: To investigate the mechanism of HOXC4 gene during early development in zebrafish, study it's expression in hematopoiesis system with whole mount in situ hybridization (WISH), then make a foundation work for further study of HOXC4 gene in hematopoiesis development.
Regulation of Aicda expression and AID activity.
Casali et al., Irvine, United States. In Autoimmunity, 2013
Transcription factors, such as HoxC4 and NF-κB, which are up-regulated in a B cell lineage-and/or differentiation stage-specific manner, regulate the induction of AID.
Hormones and AID: balancing immunity and autoimmunity.
Schmitz et al., Milano, Italy. In Autoimmunity, 2013
Those regulatory pathways can be direct when the estrogen receptor (ER) binds the AID promoter, or indirect via activation of transcription factors that enhance AID expression (e.g., HoxC4).
APRIL stimulates NF-κB-mediated HoxC4 induction for AID expression in mouse B cells.
Casali et al., Taejŏn, South Korea. In Cytokine, 2013
We have previously reported that the highly conserved homeodomain HoxC4 transcription factor binds to the Aicda (AID gene) promoter to induce AID expression.
DNA methylation profiles of long- and short-term glioblastoma survivors.
Latif et al., Birmingham, United Kingdom. In Epigenetics, 2013
Our preliminary study also identified a set of CpG loci differentially hypermethylated between STS and LTS cases, including members of the homeobox gene family (HOXD8, HOXD13 and HOXC4), the transcription factors NR2F2 and TFAP2A, and Dickkopf 2, a negative regulator of the wnt/β-catenin signaling pathway.
HOXC4 homeoprotein efficiently expands human hematopoietic stem cells and triggers similar molecular alterations as HOXB4.
Vigon et al., Paris, France. In Haematologica, 2012
HOXC4 homeoprotein expands human hematopoietic immature cells by 3 to 6 times ex vivo and significantly improves the level of in vivo engraftment.
AID dysregulation in lupus-prone MRL/Fas(lpr/lpr) mice increases class switch DNA recombination and promotes interchromosomal c-Myc/IgH loci translocations: modulation by HoxC4.
Casali et al., Irvine, United States. In Autoimmunity, 2011
These findings suggest that in lupus B cells, upregulation of HoxC4 plays a major role in dysregulation of AID expression.
Estrogen receptors bind to and activate the HOXC4/HoxC4 promoter to potentiate HoxC4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch DNA recombination, and somatic hypermutation.
Casali et al., Irvine, United States. In J Biol Chem, 2010
Esr1 bind to and activate the HOXC4 promoter to potentiate HoxC4-mediated AID induction, immunoglobulin class switch and somatic hypermutation.
HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation.
Casali et al., Irvine, United States. In Nat Immunol, 2009
HoxC4 directly activates the Aicda promoter
[Effect of human cytomegalovirus infection on the expression of hoxc4 and hoxc6 genes in the proliferation of lymphocytic progenitor cells].
Chen et al., Taiwan. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2009
Human cytomegalovirus downregulates while all-trans retinoic acid upregulates expression of hoxc4 and hoxc6 in lymphocytic progenitor cells.
Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination.
Casali et al., Irvine, United States. In Crit Rev Immunol, 2006
Integration of different intracellular signal transduction pathways, as activated by these stimuli, leads to a dynamic aicda-regulating program, which involves both positively acting trans-factors, such as Pax5, HoxC4, E47, and Irf8, and negative modulators, such as Blimp1 and Id2, to restrict aicda expression primarily to germinal center B cells.
[Ex vivo expansion of human hematopoietic stem cells by passive transduction of the HOXB4 homeoprotein].
Fichelson et al., Paris, France. In J Soc Biol, 2005
We then looked for synergistic activities between HOXB4 and other homeoproteins such as HOXC4.
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