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Homeobox C11

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, NUP98, Hoxd11, CHIP, HOXA9
Papers on HOXC11
Deletions of 5' HOXC genes are associated with lower extremity malformations, including clubfoot and vertical talus.
Gurnett et al., Saint Louis, United States. In J Med Genet, Feb 2016
SNP analysis revealed HOXC11 p.Ser191Phe segregating with clubfoot in a small family and enrichment of HOXC12 p.Asn176Lys in patients with clubfoot or vertical talus (rs189468720, p=0.0057,
Identification of genomic aberrations in hemangioblastoma by droplet digital PCR and SNP microarray highlights novel candidate genes and pathways for pathogenesis.
Toren et al., Tel Aviv-Yafo, Israel. In Bmc Genomics, Dec 2015
CONCLUSIONS: Our findings provide the first high-resolution genome-wide view of chromosomal changes in hemangioblastoma and identify 23 candidate genes: EGFR, PRDM16, PTPN11, HOXD11, HOXD13, FLT3, PTCH, FGFR1, FOXP1, GPC3, HOXC13, HOXC11, MKL1, CHEK2, IRF4, GPHN, IKZF1, RB1, HOXA9, and micro RNA, such as hsa-mir-196a-2 for hemangioblastoma pathogenesis.
The association analysis of lncRNA HOTAIR genetic variants and gastric cancer risk in a Chinese population.
Zhang et al., Nanjing, China. In Oncotarget, Nov 2015
Further functional experiments revealed the allele-specific effects on HOTAIR and HOXC11 expressions in gastric cancer tissues, of which HOTAIR and HOXC11 expressions of individuals carrying with AG genotype were much higher than those with AA genotype; similarly, the effects occurred in intronic promoter activities, of which the promoter activity of G allele was more pronounced than that of A allele.
Transcriptional dynamics of homeobox C11 gene in water buffalo bubalus bubalis.
Ali et al., New Delhi, India. In Dna Cell Biol, Jun 2015
We cloned full-length sequence of Hoxc11 gene from water buffalo Bubalus bubalis, assessed its copy number, localized the same onto the chromosome 5, and studied its evolutionary conservation across the species.
Overexpression of HOXC11 homeobox gene in clear cell renal cell carcinoma induces cellular proliferation and is associated with poor prognosis.
Lin et al., Shanghai, China. In Tumour Biol, Apr 2015
The expression of HOXC11 was detected through polymerase chain reaction and immunohistochemical staining, and we demonstrated that HOXC11 was significantly higher in renal cell carcinoma (RCC) compared to normal kidney tissue.
Biology of upper-body and lower-body adipose tissue--link to whole-body phenotypes.
Pinnick et al., Oxford, United Kingdom. In Nat Rev Endocrinol, Feb 2015
New data suggest that the profound functional differences between the upper-body and lower-body tissues are controlled by site-specific sets of developmental genes, such as HOXA6, HOXA5, HOXA3, IRX2 and TBX5 in subcutaneous abdominal adipose tissue and HOTAIR, SHOX2 and HOXC11 in gluteofemoral adipose tissue, which are under epigenetic control.
Prosaposin activates the androgen receptor and potentiates resistance to endocrine treatment in breast cancer.
McIlroy et al., Dublin, Ireland. In Breast Cancer Res, 2014
We previously identified HOXC11 to be an indicator of poor response to hormonal therapy in breast cancer.
Akt1 mediates the posterior Hoxc gene expression through epigenetic modifications in mouse embryonic fibroblasts.
Kim et al., Seoul, South Korea. In Biochim Biophys Acta, 2014
Furthermore, exogenous Akt1 was enriched at the promoter region of the posterior Hoxc genes such as Hoxc11 and Hoxc12, not the Akt1-independent Hoxc5 and Hoxd10 loci.
Multiplexed direct genomic selection (MDiGS): a pooled BAC capture approach for highly accurate CNV and SNP/INDEL detection.
Gurnett et al., Saint Louis, United States. In Nucleic Acids Res, 2014
PITX1 nonsense and HOXC11 S191F missense mutations were identified that segregate in clubfoot families.
Global gene repression by the steroid receptor coactivator SRC-1 promotes oncogenesis.
Young et al., Ireland. In Cancer Res, 2014
Combined SRC-1 and HOXC11 ChIPseq analysis identified the differentiation marker, CD24, and the apoptotic protein, PAWR, as direct SRC-1/HOXC11 suppression targets.
Differential expression of Homeobox C11 protein in water buffalo Bubalus bubalis and its putative 3D structure.
Ali et al., New Delhi, India. In Bmc Genomics, 2013
However, expression pattern of Homeobox C11 (Hoxc11) gene in the 5' region, particularly in higher mammals remains largely unexplored.
Pitx1 broadly associates with limb enhancers and is enriched on hindlimb cis-regulatory elements.
Menke et al., Athens, United States. In Dev Biol, 2013
Earlier studies suggested that the hindlimb transcription factors Tbx4, HoxC10, and HoxC11 might be transcriptional targets of Pitx1, but definitive evidence for direct regulatory interactions has been lacking.
Methylation alterations of WT1 and homeobox genes in inflamed muscle biopsy samples from patients with untreated juvenile dermatomyositis suggest self-renewal capacity.
Pachman et al., Chicago, United States. In Arthritis Rheum, 2012
Six homeobox genes were among them; ALX4, HOXC11, HOXD3, and HOXD4 were hypomethylated, while EMX2 and HOXB1 were hypermethylated.
Changing topographic Hox expression in blood vessels results in regionally distinct vessel wall remodeling.
Awgulewitsch et al., In Biol Open, 2012
To test this proposition, we expanded the vascular Hoxc11 expression domain normally restricted to the lower limbs by utilizing an innovative integrated tetracycline regulatory system and Transgelin promoter elements to induce Hoxc11 expression universally in VSMCs of transgenic mice.
Hox11 genes establish synovial joint organization and phylogenetic characteristics in developing mouse zeugopod skeletal elements.
Pacifici et al., Philadelphia, United States. In Development, 2010
Hox11 genes (Hoxa11, Hoxc11 and Hoxd11) co-regulate and coordinate the development of zeugopod skeletal elements and adjacent elbow and knee joints, and dictate joint identity, morphogenesis and anatomical and functional organization.
Interaction of developmental transcription factor HOXC11 with steroid receptor coactivator SRC-1 mediates resistance to endocrine therapy in breast cancer [corrected].
Young et al., Dublin, Ireland. In Cancer Res, 2010
HOXC11 and SRC-1 cooperate to regulate expression of the calcium-binding protein S100beta in resistant breast cancer cells.
HOXC6 and HOXC11 increase transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwannian cells.
Moriuchi et al., Sapporo, Japan. In J Cell Mol Med, 2007
HOXC11 increases transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwann cells.
Role of Pitx1 upstream of Tbx4 in specification of hindlimb identity.
Tabin et al., Boston, United States. In Science, 1999
Misexpression of Pitx1 in the chick wing bud induced distal expression of Tbx4, as well as HoxC10 and HoxC11, which are normally restricted to hindlimb expression domains.
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