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Homeobox B9

Hoxb9, Hox-2.5
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, FATE, Hoxb1
Papers on Hoxb9
HOXB9 induction of mesenchymal-to-epithelial transition in gastric carcinoma is negatively regulated by its hexapeptide motif.
Zhu et al., Shanghai, China. In Oncotarget, Jan 2016
HOXB9, a transcription factor, plays an important role in development.
GalNAc-T14 promotes metastasis through Wnt dependent HOXB9 expression in lung adenocarcinoma.
Cha et al., Seoul, South Korea. In Oncotarget, Jan 2016
Microarray and biochemical analyses revealed that HOXB9, the expression of which was increased in a GalNAc-T14-dependent manner, played an important role in metastasis.
Gene expression patterns through oral squamous cell carcinoma development: PD-L1 expression in primary tumor and circulating tumor cells.
Ribeiro-Silva et al., Ribeirão Preto, Brazil. In Oncotarget, Sep 2015
Correlation was shown between PD-L1 and tumor size and lymph node metastasis, HOXB9 and tumor size, BLNK and perineural invasion, and between ZNF813 and perineural invasion.
De novo deletion of HOXB gene cluster in a patient with failure to thrive, developmental delay, gastroesophageal reflux and bronchiectasis.
Õunap et al., Tartu, Estonia. In Eur J Med Genet, Jun 2015
550 362-46 784 039)×1) encompassing only 9 genes - HOXB1 to HOXB9.
High expression of transcriptional factor HoxB9 predicts poor prognosis in patients with lung adenocarcinoma.
Zhang et al., Beijing, China. In Histopathology, Jun 2015
AIMS: HoxB9, as a Hox family member, is known to play important roles in embryonic development.
Kindlin-2 induced by TGF-β signaling promotes pancreatic ductal adenocarcinoma progression through downregulation of transcriptional factor HOXB9.
Zhang et al., Beijing, China. In Cancer Lett, Jun 2015
Mechanistically, Kindlin-2 promotes PDAC progression by downregulation of HOXB9 and E-cadherin.
The effect and mechanism of miR196a in HepG2 cell.
Zhao et al., Taiyuan, China. In Biomed Pharmacother, May 2015
The P53, caspase-3, HOXB9, HOXB8 mRNA and their protein was detected by qPCR and Western-blot.
Possible association of single nucleotide polymorphisms in the 3' untranslated region of HOXB9 with acetabular overcoverage.
Chosa et al., Miyazaki, Japan. In Bone Joint Res, Apr 2015
METHODS: We investigated 19 total SNPs in the four HOX9 paralogs, then focused in detail on seven of those located in the 3' untranslated region of HOXB9 (rs8844, rs3826541, rs3826540, rs7405887, rs2303485, rs2303486, rs79931349) using a case-control association study.
HOXB9 promotes epithelial-to-mesenchymal transition via transforming growth factor-β1 pathway in hepatocellular carcinoma cells.
Ji et al., Dalian, China. In Clin Exp Med, Feb 2015
Homeobox B9 (HOXB9) has been proposed as an oncogene in many cancer developments, but its function and underlying mechanisms in HCC metastasis remain unknown.
The role of HOXB9 and miR-196a in head and neck squamous cell carcinoma.
Hunter et al., Sheffield, United Kingdom. In Plos One, 2014
Expression of miR196a and HOXB9 was reduced using anti-miR-196a and siRNA, respectively.
Ubiquitin-like protein FAT10 promotes the invasion and metastasis of hepatocellular carcinoma by modifying β-catenin degradation.
Shao et al., Nanchang, China. In Cancer Res, 2014
The ubiquitin-like protein FAT10 and the homeobox protein HOXB9 each promote metastatic progression in hepatocellular carcinoma (HCC).
Elevated HOXB9 expression promotes differentiation and predicts a favourable outcome in colon adenocarcinoma patients.
Zhang et al., Beijing, China. In Br J Cancer, 2014
Homeodomain-containing transcription factor HOXB9 plays an important role in embryogenesis and cancer development.
Gene microarray analysis of the lncRNA expression profile in human urothelial carcinoma of the bladder.
Wu et al., Shanghai, China. In Int J Clin Exp Med, 2013
KRT8P13, KRT8P10, BC072678, and downregulated, such as nc-HOXB9-206, RP11-160A10.2,
An E2F1-HOXB9 transcriptional circuit is associated with breast cancer progression.
Kitagawa et al., Tokyo, Japan. In Plos One, 2013
Homeobox B9 (HOXB9), a member of the homeobox gene family, is overexpressed in breast cancer and promotes tumor progression and metastasis by stimulating epithelial-to-mesenchymal transition and angiogenesis within the tumor microenvironment.
Silencing of homeobox B9 is associated with down-regulation of CD56 and extrathyroidal extension of tumor in papillary thyroid carcinoma.
Park et al., Suwŏn, South Korea. In Hum Pathol, 2012
reduced expression of CD56 is associated with homeobox B9 in papillary thyroid carcinomas. Further, silencing of homeobox B9 is more common in older age and is linked to extrathyroidal extension and advanced pathologic stage of papillary thyroid carcinoma
HOXB9 expression promoting tumor cell proliferation and angiogenesis is associated with clinical outcomes in breast cancer patients.
Kitagawa et al., Tokyo, Japan. In Ann Surg Oncol, 2012
HOXB9 overexpression promoting tumor cell proliferation and angiogenesis is associated with breast cancer.
Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses.
Maheswaran et al., United States. In Proc Natl Acad Sci U S A, 2012
The effect of HOXB9 on the response to ionizing radiation requires the baseline ATM activity before irradiation and epithelial-to-mesenchymal transition induced by TGF-beta.
Histone methylases MLL1 and MLL3 coordinate with estrogen receptors in estrogen-mediated HOXB9 expression.
Mandal et al., Arlington, United States. In Biochemistry, 2011
HOXB9 is an E2-responsive gene and ERs coordinate with MLL1 and MLL3 in E2-mediated transcriptional regulation of HOXB9.
HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis.
Maheswaran et al., United States. In Proc Natl Acad Sci U S A, 2010
deregulated expression of HOXB9 contributes to breast cancer progression and lung metastasis by inducing several growth factors that alter tumor-specific cell fates and the tumor stromal microenvironment
WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis.
Massagué et al., New York City, United States. In Cell, 2009
Two WNT target genes, LEF1 and HOXB9, are identified as promoters of lung adenocarcinoma metastasis and mediators of chemotactic invasion and colony outgrowth.
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