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Homeobox B8

Hoxb8, Hox-2.4
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HOXB7, Antennapedia, Interleukin-3, ACID
Papers on Hoxb8
The effect and mechanism of miR196a in HepG2 cell.
Zhao et al., Taiyuan, China. In Biomed Pharmacother, May 2015
The P53, caspase-3, HOXB9, HOXB8 mRNA and their protein was detected by qPCR and Western-blot.
Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation.
Mimori et al., Beppu, Japan. In Br J Cancer, Mar 2015
We identified HOXB8 as a potential target gene of miR-718, and its upregulation was associated with poor prognosis.
HPV16 early gene E5 specifically reduces miRNA-196a in cervical cancer cells.
Kee et al., Beijing, China. In Sci Rep, 2014
In addition, HoxB8, a known miR196a target gene, is up-regulated in the HPV16 cervical carcinoma cell line but not in HPV18 cervical cancer cell lines.
ATRA and As₂O₃ regulate differentiation of human hematopoietic stem cells into granulocyte progenitor via alteration of HoxB8 expression.
Xu et al., China. In Eur Rev Med Pharmacol Sci, 2014
OBJECTIVE: This study aimed to investigate the effect of all-trans retinoic acid (ATRA) and/or arsenic trioxide (As2O3) on homeobox B8 (HOXB8) mRNA and protein expressions during the differentiation and proliferation of hematopoietic stem cells (HSCs) to colony forming unit-granulocyte (CFU-G) in order to explore the pathogenesis of leukemia mediated by HOXB8 at mRNA and protein level.
Characterization of spinal cord glial cells in a model of hindlimb unloading in mice.
Islamov et al., Kazan', Russia. In Neuroscience, 2014
In control mice, homeobox protein HoxB8 (HoxB8+) cells were found only in the CC; in contrast, HoxB8+ cells were observed in all studied areas in HUM mice, with the greatest number found in the CC.
Interleukin-3-mediated regulation of β-catenin in myeloid transformation and acute myeloid leukemia.
D'Andrea et al., Adelaide, Australia. In J Leukoc Biol, 2014
In a murine model of HoxB8 and IL-3 cooperation, we show that β-catenin protein levels are modulated by IL-3 and that Cre-induced deletion of β-catenin abolishes IL-3-dependent growth and colony formation.
FMRP regulates miR196a-mediated repression of HOXB8 via interaction with the AGO2 MID domain.
Zhang et al., Shenzhen, China. In Mol Biosyst, 2014
In this research, we find that HOXB8 mRNA is a target of FMRP associated with miR-196a-induced silencing, and discover that phosphorylation of FMRP promotes the miR-196a-mediated repression of HOXB8 without affecting the interaction between FMRP and mRNA.
Establishment of a predictive genetic model for estimating chemotherapy sensitivity of colorectal cancer with synchronous liver metastasis.
Huang et al., Fuzhou, China. In Cancer Biother Radiopharm, 2013
Seven candidate genes (NKX2-3, FXYD6, TGFB1I1, ACTG2, ANPEP, HOXB8, and KLK11), which exhibited positive or negative correlations, were incorporated into a genetic model, with an overall accurate predication rate of 93.3%.
Microarray expression profiling identifies genes with altered expression in Adolescent Idiopathic Scoliosis.
Moldovan et al., Montréal, Canada. In Eur Spine J, 2013
A drastic and significant change has been noted particularly in the expression levels of Homeobox genes (HOXB8, HOXB7, HOXA13, HOXA10), ZIC2, FAM101A, COMP and PITX1 in AIS compared to controls.
HOXB8 expression in ovarian serous carcinoma effusions is associated with shorter survival.
Davidson et al., Oslo, Norway. In Gynecol Oncol, 2013
HOXB5 and HOXB8 were previously shown to be overexpressed in ovarian/primary peritoneal serous carcinoma compared to breast carcinoma using gene expression arrays.
Identification of HOXB8 and KLK11 expression levels as potential biomarkers to predict the effects of FOLFOX4 chemotherapy.
Pan et al., Fuzhou, China. In Future Oncol, 2013
Immunohistochemical analysis was performed to characterize the pattern of HOXB8 and KLK11 expression.
Distinct developmental signatures of human abdominal and gluteal subcutaneous adipose tissue depots.
Smith et al., Boston, United States. In J Clin Endocrinol Metab, 2013
Most notably, gene ontology and pathway analysis identified homeobox genes (HOXA2, HOXA3, HOXA4, HOXA5, HOXA9, HOXB7, HOXB8, HOXC8, and IRX2) that were down-regulated in the gluteal depot in both sexes (P = 2 × 10(-10)).
Hematopoietic origin of pathological grooming in Hoxb8 mutant mice.
Capecchi et al., Salt Lake City, United States. In Cell, 2010
Mouse Hoxb8 mutants show unexpected behavior manifested by compulsive grooming and hair removal further, transplantation of wild-type bone marrow into Hoxb8 mutant mice rescues their pathological phenotype.
Loss of Hoxb8 alters spinal dorsal laminae and sensory responses in mice.
Deschamps et al., Rotterdam, Netherlands. In Proc Natl Acad Sci U S A, 2008
A lower number of neurons in the upper spinal laminae and neuronal disorganization in the dorsal horn underlie the sensory defects including the excessive grooming of the Hoxb8 mutant.
Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8.
Koseki et al., Yokohama, Japan. In Development, 2006
Results indicate distinct roles for class 2 Polycomb group complexes in transcriptionally repressed and active domains of Hoxb8 gene.
The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development.
Tabin et al., Boston, United States. In Nature, 2006
miR-196 acts upstream of Hoxb8 and Sonic hedgehog (Shh) in vivo in the context of limb development, thereby identifying a previously observed but uncharacterized inhibitory activity that operates specifically in the hindlimb
MicroRNA-directed cleavage of HOXB8 mRNA.
Bartel et al., Cambridge, United States. In Science, 2004
RNA fragments diagnostic of miR-196-directed cleavage of HOXB8 were detected in mouse embryos; results point to a miRNA-mediated mechanism for the posttranscriptional restriction of HOX gene expression during vertebrate development
MicroRNA-196 inhibits HOXB8 expression in myeloid differentiation of HL60 cells.
Taira et al., Tokyo, Japan. In Nucleic Acids Symp Ser (oxf), 2003
These results suggest that miR-196 participates in myeloid differentiation of HL60 cells via regulation of HOXB8 expression.
Hoxb-8 gain-of-function transgenic mice exhibit alterations in the peripheral nervous system.
Deschamps et al., Utrecht, Netherlands. In J Neurosci Methods, 1997
To understand the developmental role of Hoxb-8, this relatively 5' Hoxb gene was ectopically expressed in embryonic regions where only more 3' Hox genes are normally expressed.
Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures.
Deschamps et al., Utrecht, Netherlands. In Cell, 1994
Transgenic embryos were generated carrying a Hoxb-8 transgene under control of the mouse RAR beta 2 promoter, which extends the normal expression domain to more anterior regions of the embryo.
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