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Homeobox B7

HOXB7, Hox-2.3
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, Antennapedia, ACID, POLYMERASE
Papers using HOXB7 antibodies
Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation.
Hakimi Mohamed-Ali, In PLoS ONE, 2006
... Anti-FLAG M2 (Sigma), anti-PARP monoclonal antibody (clone C-2–10, Invitrogen), polyclonal anti-HOXB7 antibody (Invitrogen) and monoclonal anti-HOXB7 antibody (Abcam).
Papers on HOXB7
Conditional knockout of collecting duct bradykinin B2 receptors exacerbates angiotensin II-induced hypertension during high salt intake.
El-Dahr et al., Praha, Czech Republic. In Clin Exp Hypertens, Jan 2016
To this end, we used a Cre-Lox recombination strategy to generate mice lacking Bdkrb2 gene for B2R in the collecting duct (Hoxb7-Cre(tg/+):Bdkrb2(flox/flox)).
Double transduction of a Cre/LoxP lentiviral vector: a simple method to generate kidney cell-specific knockdown mice.
Kang et al., Seoul, South Korea. In Am J Physiol Renal Physiol, Jan 2016
Kidney collecting duct (CD)-specific aquaporin-3 (AQP3)-knockdown mice were generated by consecutive injection of Hoxb7-Cre-expressing lentivirus (LV-Hoxb7 Cre) and loxP-AQP3 shRNA-expressing lentivirus (LV-loxP shAQP3) in adult C57BL6/J mice.
Overexpression of HOXB7 is associated with a poor prognosis in patients with gastric cancer.
Zhou et al., Nanjing, China. In Oncol Lett, Nov 2015
Reverse transcription-quantitative polymerase chain reaction and western blot analysis were used to detect the expression of the homeobox B7 (HOXB7) RNA and protein, respectively.
Inhibition of 13-cis retinoic acid-induced gene expression of reactive-resistance genes by thalidomide in glioblastoma tumours in vivo.
Herskind et al., Freiburg, Germany. In Oncotarget, Nov 2015
However, RA may also induce the expression of resistance genes such as HOXB7 which can be suppressed by Thalidomide (THAL).
HOXB7-S3 inhibits the proliferation and invasion of MCF-7 human breast cancer cells.
Lin et al., Wuhan, China. In Mol Med Report, Oct 2015
Homeobox B7 (HOXB7) has been found to be overexpressed in numerous types of human cancer.
Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk.
Pharoah et al., Cambridge, United Kingdom. In Cancer Epidemiol Biomarkers Prev, Oct 2015
RESULTS: Gene set enrichment analysis identified six networks centered on TF genes (HOXB2, HOXB5, HOXB6, HOXB7 at 17q21.32 and HOXD1, HOXD3 at 2q31) that were significantly enriched for genes from the risk-associated end of the ranked list (P < 0.05 and FDR < 0.05).
Vascular versus tubular renin: role in kidney development.
Gomez et al., Iowa City, United States. In Am J Physiol Regul Integr Comp Physiol, Oct 2015
Therefore, we deleted renin independently in the vascular and tubular compartments by crossing Ren1(c fl/fl) mice to Foxd1-cre and Hoxb7-cre mice, respectively.
HOXB7 Is an ERα Cofactor in the Activation of HER2 and Multiple ER Target Genes Leading to Endocrine Resistance.
Sukumar et al., Budapest, Hungary. In Cancer Discov, Sep 2015
HOXB7 chromatin immunoprecipitation analysis followed by validation showed that HOXB7 physically interacts with ERα, and that the HOXB7-ERα complex enhances transcription of many ERα target genes, including HER2.
Targeting a Novel ER/HOXB7 Signaling Loop in Tamoxifen-Resistant Breast Cancer.
Hynes et al., Basel, Switzerland. In Cancer Discov, Sep 2015
Jin and colleagues describe a novel ER/HOXB7 signaling loop in tamoxifen-resistant breast cancer models.
Upregulation of HOXB7 promotes the tumorigenesis and progression of gastric cancer and correlates with clinical characteristics.
Wu et al., Hangzhou, China. In Tumour Biol, Sep 2015
Notwithstanding homeobox B7 (HOXB7) has been documented that its deregulation promotes carcinogenesis and development in gastrointestinal tract, its function in gastric cancer has not been investigated.
Zhang et al., Kunming, China. In J Biol Regul Homeost Agents, Jul 2015
HoxB7 is involved in cell migration and metastasis in many malignant tumors.
Deregulated HOXB7 Expression Predicts Poor Prognosis of Patients with Esophageal Squamous Cell Carcinoma and Regulates Cancer Cell Proliferation In Vitro and In Vivo.
Chen et al., Beijing, China. In Plos One, 2014
BACKGROUND: We observed abnormal HOXB7 expression in esophageal squamous cell carcinoma (ESCC) previously.
Homeobox B7 promotes the osteogenic differentiation potential of mesenchymal stem cells by activating RUNX2 and transcript of BSP.
Li et al., Beijing, China. In Int J Clin Exp Med, 2014
Here, we investigate HOXB7 function in the osteogenic differentiation potentials of MSCs using stem cells from apical papilla (SCAPs) and bone marrow stem cells (BMSCs).
A pivotal role for HOXB7 protein in endocrine resistant breast cancer.
Sukumar et al., Baltimore, United States. In Oncoscience, 2014
HOXB7 is a homeodomain containing transcription factor which plays a pivotal role in tamoxifen resistant breast cancer.
Functional cooperation between human adenovirus type 5 early region 4, open reading frame 6 protein, and cellular homeobox protein HoxB7.
Dobner et al., Hamburg, Germany. In J Virol, 2012
the absence of HoxB7 leads to inefficient viral progeny production, as HAdV5 gene expression is highly regulated by HoxB7-mediated activation of various adenoviral promoters.
Evidence for a functional role of epigenetically regulated midcluster HOXB genes in the development of Barrett esophagus.
Fitzgerald et al., Cambridge, United Kingdom. In Proc Natl Acad Sci U S A, 2012
HOXB5, HOXB6, and HOXB7 are activated in Barrett esophagus, and the midcluster HOXB gene signature in BE most resembled the colon rather than other GI epithelia.
HOXB7 expression is a prognostic factor for oral squamous cell carcinoma.
Coletta et al., In Histopathology, 2012
The current study demonstrates that the expression of HOXB7 is an independent prognostic marker for oral squamous cell carcinoma.
The HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathway.
Sukumar et al., Baltimore, United States. In Proc Natl Acad Sci U S A, 2012
Up-regulation of EGFR occurs through direct binding of HOXB7 to the EGFR promoter, enhancing transcriptional activity.
Overexpression of HOXB7 and homeobox genes characterizes multiple myeloma patients lacking the major primary immunoglobulin heavy chain locus translocations.
Giuliani et al., Milano, Italy. In Am J Hematol, 2011
Data indicate that HOXB7 and related HOX genes are upregulated in plasma cells of specific subsets of multiple myeloma patients lacking major immunoglobulin heavy chain locus translocations, irrespective of hyperdiploidy or other cytogenetic lesions.
Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia.
Plass et al., Columbus, United States. In Cell, 2007
DAPK1 expression of the CLL allele is downregulated by 75% in germline cells due to increased HOXB7 binding.
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