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Homeobox B1

Hoxb1, Hox-2.9, hoxb1a
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, HOXA1, Early Growth Response Protein 2, CAN, TUBE
Papers on Hoxb1
Glyphosate induces neurotoxicity in zebrafish.
Ochs et al., Fairfield, United States. In Environ Toxicol Pharmacol, Feb 2016
However, we do not detect changes in hindbrain expression domains of ephA4 nor exclusive hindbrain markers krox-20 and hoxb1a.
Fitness Assays Reveal Incomplete Functional Redundancy of the HoxA1 and HoxB1 Paralogs of Mice.
Potts et al., Salt Lake City, United States. In Genetics, Oct 2015
Here we discriminate between these hypotheses by competing mice (Mus musculus) whose Hoxb1 gene has been replaced by Hoxa1, its highly conserved paralog, against matched wild-type controls in seminatural enclosures.
A new hereditary congenital facial palsy case supports arg5 in HOX-DNA binding domain as possible hot spot for mutations.
Kayserili et al., İstanbul, Turkey. In Eur J Med Genet, Jun 2015
Mutant mice for Hoxb1 were reported to present with facial weakness, resembling MBS.
De novo deletion of HOXB gene cluster in a patient with failure to thrive, developmental delay, gastroesophageal reflux and bronchiectasis.
Õunap et al., Tartu, Estonia. In Eur J Med Genet, Jun 2015
550 362-46 784 039)×1) encompassing only 9 genes - HOXB1 to HOXB9.
HOXB1 Is a Tumor Suppressor Gene Regulated by miR-3175 in Glioma.
Tian et al., Changchun, China. In Plos One, 2014
The HOXB1 gene plays a critical role as an oncogene in diverse tumors.
Epigenetic repression of HOXB cluster in oral cancer cell lines.
Nunes et al., Salvador, Brazil. In Arch Oral Biol, 2014
RESULTS: Methylation greater than 50% was detected in HOXA11, HOXA6, HOXA7, HOXA9, HOXB1, HOXB2, HOXB3, HOXB4, HOXB5, HOXB6, HOXC8 and HOXD10.
Diagnostic distinctions and genetic analysis of patients diagnosed with moebius syndrome.
Engle et al., Riyadh, Saudi Arabia. In Ophthalmology, 2014
METHODS: Participants underwent standardized ophthalmologic examination for Moebius syndrome minimum diagnostic criteria (MDC) (congenital, nonprogressive facial palsy, and abduction deficit) and genetic testing for HOXA1, HOXB1, and TUBB3 mutations.
Targeted germ line disruptions reveal general and species-specific roles for paralog group 1 hox genes in zebrafish.
Sagerström et al., Worcester, United States. In Bmc Dev Biol, 2013
However, antisense-mediated interference with zebrafish hoxb1a and hoxb1b (analogous to murine Hoxb1 and Hoxa1, respectively) produces phenotypes that are qualitatively and quantitatively distinct from those observed in the mouse.
The genetic basis of incomitant strabismus: consolidation of the current knowledge of the genetic foundations of disease.
Engle et al., Boston, United States. In Semin Ophthalmol, 2013
Disorders reviewed include Duane syndrome (DS), HOXA1 and HOXB1 syndromes, Moebius syndrome, congenital fibrosis of the extraocular muscles (CFEOM), and horizontal gaze palsy with progressive scoliosis (HGPPS).
HOXB1 founder mutation in humans recapitulates the phenotype of Hoxb1-/- mice.
Jabs et al., New York City, United States. In Am J Hum Genet, 2012
The resulting phenotype includes bilateral facial palsy, hearing loss, and strabismus and correlates extensively with the previously reported Hoxb1(-/-) mouse phenotype.
Hoxb1 controls anteroposterior identity of vestibular projection neurons.
Gaufo et al., San Antonio, United States. In Plos One, 2011
Hoxb1 is required for the anterior-posterior identity of precursors that contribute to the lateral vestibular nucleus.
A screen for hoxb1-regulated genes identifies ppp1r14al as a regulator of the rhombomere 4 Fgf-signaling center.
Sagerström et al., Worcester, United States. In Dev Biol, 2011
Hoxb1b is likely to directly regulate ppp1r14al expression in rhombomere 4.
Directed neural differentiation of mouse embryonic stem cells is a sensitive system for the identification of novel Hox gene effectors.
Gouti et al., Athens, Greece. In Plos One, 2010
The results of this study show that ES neural differentiation and inducible Hox gene expression can be used as a sensitive model system to systematically identify Hox novel target genes.
An integrated meta-analysis of two variants in HOXA1/HOXB1 and their effect on the risk of autism spectrum disorders.
Miao et al., Wuhan, China. In Plos One, 2010
HOXA1 A218G and HOXB1 nINS/INS variants may not contribute significantly to autism spectrum disorders risk
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.
Helin et al., Copenhagen, Denmark. In Nature, 2007
UTX directly binds to the HOXB1 locus and is required for its activation
Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation.
Wolberger et al., Baltimore, United States. In Cell, 1999
We report here the 2.35 A structure of a ternary complex containing a human HoxB1-Pbx1 heterodimer bound to DNA.
Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity.
Krumlauf et al., London, United Kingdom. In Nature, 1993
Here we follow the changes induced by retinoic acid to hindbrain segmentation and the branchial arches using transgenic mice which contain lacZ reporter genes that reveal the endogenous segment-restricted expression of the Hox-B1 (Hox-2.9),
Neuroectodermal autonomy of Hox-2.9 expression revealed by rhombomere transpositions.
Lumsden et al., London, United Kingdom. In Nature, 1992
The rhombomere boundaries delimit domains of expression of Hox genes, presumed to be determinants of rhombomere phenotype, suggesting that Hox genes confer positional value; the formation of rhombomere 4 (r4) is followed by strong expression of Hox-2.9 within its confines.
Molecular mechanisms of pattern formation in the vertebrate hindbrain.
Wilkinson et al., London, United Kingdom. In Ciba Found Symp, 1991
-2.7 and -2.8 have progressively more anterior limits of expression at two-segment intervals, whereas expression of Hox-2.9 is restricted to one rhombomere, r4.
Segment-specific expression of a homoeobox-containing gene in the mouse hindbrain.
Hill et al., Edinburgh, United Kingdom. In Nature, 1989
Here we report that a mouse homoeobox-containing gene, Hox-2.9, is expressed in a segment-specific manner in the developing mouse hindbrain.
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