Biology of upper-body and lower-body adipose tissue--link to whole-body phenotypes.
Oxford, United Kingdom. In Nat Rev Endocrinol, Feb 2015
New data suggest that the profound functional differences between the upper-body and lower-body tissues are controlled by site-specific sets of developmental genes, such as HOXA6, HOXA5, HOXA3, IRX2 and TBX5 in subcutaneous abdominal adipose tissue and HOTAIR, SHOX2 and HOXC11 in gluteofemoral adipose tissue, which are under epigenetic control.
Genome-wide methylation and transcriptome analysis in penile carcinoma: uncovering new molecular markers.
São Paulo, Brazil. In Clin Epigenetics, 2014
CpG hypermethylation and gene underexpression were confirmed for a panel of genes, including TWIST1, RSOP2, SOX3, SOX17, PROM1, OTX2, HOXA3, and MEIS1.
Early development of the thymus in Xenopus laevis.
Chŏnju, South Korea. In Dev Dyn, 2013
Here we examined the expression of three transcription factors that have been functionally associated with pharyngeal gland development, gcm2, hoxa3, and foxn1, and evaluated the neural crest contribution to thymus development.
Distinct developmental signatures of human abdominal and gluteal subcutaneous adipose tissue depots.
Boston, United States. In J Clin Endocrinol Metab, 2013
Most notably, gene ontology and pathway analysis identified homeobox genes (HOXA2, HOXA3, HOXA4, HOXA5, HOXA9, HOXB7, HOXB8, HOXC8, and IRX2) that were down-regulated in the gluteal depot in both sexes (P = 2 × 10(-10)).
Novel genes associated with colorectal cancer are revealed by high resolution cytogenetic analysis in a patient specific manner.
Riyadh, Saudi Arabia. In Plos One, 2012
Combining GISTIC ranking with functional analyses and degree of loss/gain we identify three genes in regions of significant loss (ATP8B1, NARS, and ATP5A1) and eight in regions of gain (CTCFL, SPO11, ZNF217, PLEKHA8, HOXA3, GPNMB, IGF2BP3 and PCAT1) as novel in their association with CRC.
HoxA3 is an apical regulator of haemogenic endothelium.
Minneapolis, United States. In Nat Cell Biol, 2011
Data show that HoxA3 restrains haematopoietic differentiation of the earliest endothelial progenitors, and induces reversion of the earliest haematopoietic progenitors into CD41-negative endothelial cells.