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Homeobox A3

Hoxa3, Hox-1.5
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, ACID, Hoxa5, Antennapedia, SET
Papers on Hoxa3
Coordination of AUF1 and miR-148a destabilizes DNA methyltransferase 1 mRNA under hypoxia in endometriosis.
Tsai et al., Tainan City, Taiwan. In Mol Hum Reprod, Dec 2015
Levels of proteins of three hypermethylated genes in endometrial stroma cells, GATA6, HOXA3 and SLC16A5, were elevated after 72 h of hypoxia treatment (P < 0.05 versus control).
Biology of upper-body and lower-body adipose tissue--link to whole-body phenotypes.
Pinnick et al., Oxford, United Kingdom. In Nat Rev Endocrinol, Feb 2015
New data suggest that the profound functional differences between the upper-body and lower-body tissues are controlled by site-specific sets of developmental genes, such as HOXA6, HOXA5, HOXA3, IRX2 and TBX5 in subcutaneous abdominal adipose tissue and HOTAIR, SHOX2 and HOXC11 in gluteofemoral adipose tissue, which are under epigenetic control.
Genome-wide methylation and transcriptome analysis in penile carcinoma: uncovering new molecular markers.
Rogatto et al., São Paulo, Brazil. In Clin Epigenetics, 2014
CpG hypermethylation and gene underexpression were confirmed for a panel of genes, including TWIST1, RSOP2, SOX3, SOX17, PROM1, OTX2, HOXA3, and MEIS1.
Secreted HoxA3 Promotes Epidermal Proliferation and Angiogenesis in Genetically Modified Three-Dimensional Composite Skin Constructs.
Boudreau et al., San Francisco, United States. In Adv Wound Care (new Rochelle), 2014
Previous studies have shown that gene transfer of HoxA3 to wounds of diabetic mice accelerates wound healing, increasing angiogenesis and keratinocyte migration.
Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse.
Manley et al., Athens, United States. In Development, 2014
Hoxa3 was the first Hox gene to be mutated by gene targeting in mice and is required for the development of multiple endoderm and neural crest cell (NCC)-derived structures in the pharyngeal region.
CTCF controls HOXA cluster silencing and mediates PRC2-repressive higher-order chromatin structure in NT2/D1 cells.
Liang et al., Beijing, China. In Mol Cell Biol, 2014
Here, we demonstrate that the HOXA locus is organized by CTCF into chromatin loops and that CTCF depletion causes significantly enhanced activation of HOXA3 to -A7, -A9 to -A11, and -A13 in response to retinoic acid, with the highest effect observed for HOXA9.
The absence of mutations in homeobox candidate genes HOXA3, HOXB3, HOXD3 and PITX2 in familial and sporadic thyroid hemiagenesis.
Maciel et al., In J Pediatr Endocrinol Metab, 2014
OBJECTIVE: The aim of this work was to search for mutations in thyroid developmental candidate genes HOXA3, HOXB3, HOXD3 and PITX2.
DNA methylation study of fetus genome through a genome-wide analysis.
Zhu et al., Zhengzhou, China. In Bmc Med Genomics, 2013
These DNA markers all found to be associated with the critical genes for fetus growth and development (SH2D3C gene, EML3 gene, TRIM71 gene, HOXA3 gene and HOXA5 gene).
HOX antisense lincRNA HOXA-AS2 is an apoptosis repressor in all trans retinoic acid treated NB4 promyelocytic leukemia cells.
Newburger et al., Worcester, United States. In J Cell Biochem, 2013
HOXA cluster antisense RNA 2 (HOXA-AS2) is a long non-coding RNA located between the HOXA3 and HOXA4 genes in the HOXA cluster.
Early development of the thymus in Xenopus laevis.
Saint-Jeannet et al., Chŏnju, South Korea. In Dev Dyn, 2013
Here we examined the expression of three transcription factors that have been functionally associated with pharyngeal gland development, gcm2, hoxa3, and foxn1, and evaluated the neural crest contribution to thymus development.
Distinct developmental signatures of human abdominal and gluteal subcutaneous adipose tissue depots.
Smith et al., Boston, United States. In J Clin Endocrinol Metab, 2013
Most notably, gene ontology and pathway analysis identified homeobox genes (HOXA2, HOXA3, HOXA4, HOXA5, HOXA9, HOXB7, HOXB8, HOXC8, and IRX2) that were down-regulated in the gluteal depot in both sexes (P = 2 × 10(-10)).
Novel genes associated with colorectal cancer are revealed by high resolution cytogenetic analysis in a patient specific manner.
Aziz et al., Riyadh, Saudi Arabia. In Plos One, 2012
Combining GISTIC ranking with functional analyses and degree of loss/gain we identify three genes in regions of significant loss (ATP8B1, NARS, and ATP5A1) and eight in regions of gain (CTCFL, SPO11, ZNF217, PLEKHA8, HOXA3, GPNMB, IGF2BP3 and PCAT1) as novel in their association with CRC.
Hoxa3 promotes the differentiation of hematopoietic progenitor cells into proangiogenic Gr-1+CD11b+ myeloid cells.
Mace et al., Manchester, United Kingdom. In Blood, 2011
Studies indicate that Hoxa3 promotes proliferation and differentiation of HSC/Ps into Gr-1+CD11b+ myeloid cells.
HoxA3 is an apical regulator of haemogenic endothelium.
Kyba et al., Minneapolis, United States. In Nat Cell Biol, 2011
Data show that HoxA3 restrains haematopoietic differentiation of the earliest endothelial progenitors, and induces reversion of the earliest haematopoietic progenitors into CD41-negative endothelial cells.
Mouse and zebrafish Hoxa3 orthologues have nonequivalent in vivo protein function.
Manley et al., Athens, United States. In Proc Natl Acad Sci U S A, 2010
demonstrate that zebrafish hoxa3a (zfhoxa3a) expressed from the mouse Hoxa3 locus can substitute for mouse Hoxa3 in some tissues, but has distinct or null phenotypes in others.
HOXA3 modulates injury-induced mobilization and recruitment of bone marrow-derived cells.
Boudreau et al., San Francisco, United States. In Stem Cells, 2009
HOXA3 accelerates wound repair by mobilizing endothelial progenitor cells and attenuating the excessive inflammatory response of chronic wounds.
HOX gene analysis of endothelial cell differentiation in human bone marrow-derived mesenchymal stem cells.
Rha et al., Seoul, South Korea. In Mol Biol Rep, 2009
HOXA7, HOXB3, HOXA3, and HOXB13 expression levels changed during angiogenesis, sugessting these proteins might be involved in the angiogenesis of hMSCs.
Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions.
Capecchi et al., Salt Lake City, United States. In Nature, 1994
We showed previously that mice homozygous for independent targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 had no defects in common.
Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5.
Capecchi et al., Salt Lake City, United States. In Nature, 1991
Gene targeting in mouse embryo-derived stem cells has been used to disrupt the homeobox gene hox-1.5.
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