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T-cell leukemia homeobox 2

HOX11L1, TLX2, Ncx, Hox11L.1
This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans, loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors. [provided by RefSeq, May 2010] (from NCBI)
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Top mentioned proteins: HOX11, Smad1, BMPR1A, HOX11L2, V1a
Papers on HOX11L1
Fgf-signaling-dependent Sox9a and Atoh1a regulate otic neural development in zebrafish.
Liu et al., Beijing, China. In J Neurosci, Feb 2015
Sox9a and Atoh1a coregulate numerous downstream factors identified through our ChIP-seq analyses, including Tlx2 and Eya2.
Analysis of genes involved in response to doxorubicin and a GD2 ganglioside-specific 14G2a monoclonal antibody in IMR-32 human neuroblastoma cells.
Rokita et al., Kraków, Poland. In Acta Biochim Pol, 2014
Next, we used RT-PCR to verify mRNA levels of selected DOX-responsive genes such as RPS27L, PPM1D, SESN1, CDKN1A, TNFSF10B, and 14G2a-responsive genes such as SVIL, JUN, RASSF6, TLX2, ID1.
PreImplantation factor (PIF*) promotes embryotrophic and neuroprotective decidual genes: effect negated by epidermal growth factor.
Barnea et al., New Haven, United States. In J Neurodev Disord, 2013
RESULTS: In HESC, PIF promotes neural differentiation and transmission genes (TLX2, EPHA10) while inhibiting retinoic acid receptor gene, which arrests growth.
[Comparative analysis of conservation and regulatory network on core transcription factors in mouse inner ear development].
Cao et al., Nanjing, China. In Yi Chuan, 2013
In addition, several transcription factors, such as Sox5, Lhx2, Rax, Otx1, Otx2, Pitxl, Pitx2, Nkx2-5, Irx4, Irx6, Dlx2, Hmx1/2/3, Pou4f3, Pax4 and Tlx2, were found to be involved in the regulatory network.
Genome-scale analysis of DNA methylation in colorectal cancer using Infinium HumanMethylation450 BeadChips.
Govorun et al., Russia. In Epigenetics, 2013
Despite the considerable variability in methylation data, we selected a panel of 14 highly robust candidates showing methylation marks in genes SND1, ADHFE1, OPLAH, TLX2, C1orf70, ZFP64, NR5A2, and COL4A.
Preanalytical evaluation of serum 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 measurements using LC-MS/MS.
Nomura et al., Chiba, Japan. In Clin Chim Acta, 2013
METHODS: We designed a method using a triple quadrupole mass spectrometer equipped with a two-step separation approach that used the Aria TLX-2 HPLC system in the selected reaction monitoring mode.
Transcriptional dysregulation and impairment of PHOX2B auto-regulatory mechanism induced by polyalanine expansion mutations associated with congenital central hypoventilation syndrome.
Fornasari et al., Milano, Italy. In Neurobiol Dis, 2013
Co-transfection experiments using equimolar amounts of PHOX2B wild-type and mutant proteins in order to simulate a heterozygous state in vitro and four different PHOX2B target gene regulatory regions (PHOX2B, PHOX2A, DBH, TLX2) clearly showed that the polyalanine expanded proteins alter the transcriptional activity of wild-type protein in a promoter-specific manner, without any clear correlation with the length of the expansion.
Simplified newborn screening protocol for lysosomal storage disorders.
Kasper et al., Vienna, Austria. In Clin Chem, 2011
METHODS: After overnight incubation (16-20 h) of dried blood spots with a cassette of substrates and deuterated internal standards, we used a TLX-2 system to quantify 6 lysosomal enzyme activities for Fabry, Gaucher, Niemann-Pick A/B, Pompe, Krabbe, and mucopolysaccharidosis I disease.
Nuclear and mitochondrial phylogeography of the European fire-bellied toads Bombina bombina and Bombina variegata supports their independent histories.
Szymura et al., Kraków, Poland. In Mol Ecol, 2011
We performed a fine-scaled multilocus phylogeographic analysis of two Bombina species combining mitochondrial variation of 950 toads from 385 sites and nuclear genes (Rag-1, Ncx-1) from a subset of samples to reconstruct their colonization and contemporary variation patterns.
Sodium-calcium exchange is essential for effective triggering of calcium release in mouse heart.
Goldhaber et al., Los Angeles, United States. In Biophys J, 2010
These results suggest that high subsarcolemmal Ca2+ is required to ensure synchronous triggering with short spark latency in the absence of NCX.
Selective interference with TRPC3/6 channels disrupts OX1 receptor signalling via NCX and reveals a distinct calcium influx pathway.
Akerman et al., Helsinki, Finland. In Cell Calcium, 2010
NCX-TRPC channel interaction constitutes an important functional unit in receptor-mediated divalent calcium ion influx in neuronal cells.
Na+/Ca2+ exchanger is a determinant of excitation-contraction coupling in human embryonic stem cell-derived ventricular cardiomyocytes.
Li et al., Davis, United States. In Stem Cells Dev, 2010
NCX is functionally expressed in developing ventricular human embryonic stem cell-derived ventricular cardiomyocytes and contributes to their excitation-contraction coupling.
Functional characterization of a minimal sequence essential for the expression of human TLX2 gene.
Ceccherini et al., Genova, Italy. In Bmb Rep, 2010
TLX2 is an orphan homeodomain transcription factor whose expression is mainly associated with tissues derived from neural crest cells.
Genetic aberrations of gastrointestinal stromal tumors.
Zhang et al., Tianjin, China. In Cancer, 2008
Molecular genetic aberrations include loss of heterozygosity of p16(INK4A) and p14(ARF), methylation of p15(INK4B), homozygous loss of the Hox11L1 gene, and amplification of C-MYC, MDM2, EGFR1, and CCND1.
Ncx (Enx, Hox11L.1) is required for neuronal cell death in enteric ganglia of mice.
Hatano et al., Chiba, Japan. In J Pediatr Surg, 2007
Ncx participates in normal developmental cell death of enteric neurons. Ncx may modulate, if not directly target, expression of the caspase-3 at the transcriptional level to participate in neuronal cell death in the enteric nervous system.
Pathogenesis of Hirschsprung's disease and its variants: recent progress.
Shinkai et al., Dublin, Ireland. In Semin Pediatr Surg, 2004
HOX11L1 knockout mice and endothelin B receptor-deficient rats demonstrated abnormalities of the ENS resembling IND type B in humans.
Intestinal neuronal dysplasia.
Puri, Dublin, Ireland. In Semin Pediatr Surg, 2003
Recently, two different HOX11L1 knockout mouse models and a heterozygous endothelin B receptor-deficient rat demonstrated abnormalities of the submucous plexus similar to that observed in human IND.
14-3-3 proteins; bringing new definitions to scaffolding.
Zhu et al., Temple, United States. In Oncogene, 2001
FKHRL1, DAF-16, p53, TAZ, TLX-2, histone deacetylase).
Rnx deficiency results in congenital central hypoventilation.
Korsmeyer et al., Saint Louis, United States. In Nat Genet, 2000
The genes Tlx1 (Hox11), Enx (Hox11L2, Tlx-2) and Rnx (Hox11L2, Tlx-3) constitute a family of orphan homeobox genes.
Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon.
Korsmeyer et al., Saint Louis, United States. In Nat Med, 1997
The isolated homeobox gene Enx (Hox11L1) is expressed in enteric neurons innervating distal ileum, and proximal and distal colon.
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