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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Nuclear receptor subfamily 4, group A, member 1

hormone-receptor, Nur77, HMR, NGFI-B
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] (from NCBI)
Top mentioned proteins: CAN, HAD, aromatase, erbB-2, AGE
Papers on hormone-receptor
Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1.
Graziani et al., Novara, Italy. In Sci Transl Med, Feb 2016
We show that down-regulation of DGKα activity in SAP-deficient T cells restores diacylglycerol signaling at the immune synapse and rescues RICD via induction of the proapoptotic proteins NUR77 and NOR1.
Pooled Analysis of the Prognostic Relevance of Circulating Tumor Cells in Primary Breast Cancer.
Lucci et al., Anderson, United States. In Clin Cancer Res, Feb 2016
Multivariate Cox regressions, which included tumor size, nodal status, histological tumor grade, and hormone-receptor and HER2 status, confirmed that the presence of CTCs was an independent prognostic factor for disease-free survival (hazard ratio (HR), 1.82; 95% confidence interval (CI), 1.47 to 2.26), distant disease-free survival (HR, 1.89; 95% CI, 1.49 to 2.40), breast cancer-specific survival (HR, 2.04; 95% CI, 1.52 to 2.75), and overall survival (HR, 1.97; 95% CI, 1.51 to 2.59).
New insights on the role of luteinizing hormone releasing hormone agonists in premenopausal early breast cancer patients.
Pronzato et al., Genova, Italy. In Cancer Treat Rev, Jan 2016
The administration of an aromatase inhibitor plus OFS represents an additional therapeutic option for hormone-receptor positive premenopausal breast cancer patients, according to the combined analysis of the SOFT and TEXT trials.
Anastrozole versus tamoxifen for the prevention of locoregional and contralateral breast cancer in postmenopausal women with locally excised ductal carcinoma in situ (IBIS-II DCIS): a double-blind, randomised controlled trial.
IBIS-II investigators et al., Newcastle, Australia. In Lancet, Jan 2016
BACKGROUND: Third-generation aromatase inhibitors are more effective than tamoxifen for preventing recurrence in postmenopausal women with hormone-receptor-positive invasive breast cancer.
Impact of race and tumor subtype on second malignancy risk in women with breast cancer.
Jabbour et al., Nashville, United States. In Springerplus, Dec 2015
However, the impact of race and the hormone receptor (HR) status of the primary breast tumor on risk of SM are not known.
Prospective Validation of a 21-Gene Expression Assay in Breast Cancer.
Sledge et al., United States. In N Engl J Med, Dec 2015
METHODS: We performed a prospective trial involving women with hormone-receptor-positive, human epidermal growth factor receptor type 2 (HER2)-negative, axillary node-negative breast cancer with tumors of 1.1 to 5.0 cm in the greatest dimension (or 0.6 to 1.0 cm in the greatest dimension and intermediate or high tumor grade) who met established guidelines for the consideration of adjuvant chemotherapy on the basis of clinicopathologic features.
Palbociclib: A Novel Cyclin-Dependent Kinase Inhibitor for Hormone Receptor-Positive Advanced Breast Cancer.
Berger et al., Columbus, United States. In Ann Pharmacother, Nov 2015
OBJECTIVE: To review palbociclib, a novel small-molecule inhibitor of cyclin-dependent kinases 4 and 6, and its current place in therapy for the treatment of hormone receptor (HMR)-positive, human epidermal growth factor receptor 2 (Her2)-negative advanced breast cancer.
Competitive Agonists and Antagonists of Steroid Nuclear Receptors: Evolution of the Concept or Its Reversal.
Smirnova, Moscow, Russia. In Biochemistry (mosc), Oct 2015
Mechanisms of in vitro action for mixed agonist/antagonist steroids are discussed depending on: specific features of their interaction with receptor hormone-binding pocket; steroid-dependent allosteric modulation of interaction between hormone-receptor complex and hormone response DNA elements; features of interacting hormone-receptor complex with protein transcriptional coregulators; level and tissue-specific composition of transcriptional coregulators.
Optimizing Endocrine Therapy for Breast Cancer.
O'Regan et al., Atlanta, United States. In J Natl Compr Canc Netw, Aug 2015
Endocrine therapy has significantly improved outcomes for patients with early- and advanced-stage hormone-receptor (HR)-positive breast cancer.
Palbociclib in Hormone-Receptor-Positive Advanced Breast Cancer.
PALOMA3 Study Group et al., Melbourne, Australia. In N Engl J Med, Aug 2015
BACKGROUND: Growth of hormone-receptor-positive breast cancer is dependent on cyclin-dependent kinases 4 and 6 (CDK4 and CDK6), which promote progression from the G1 phase to the S phase of the cell cycle.
Patient-reported outcomes with adjuvant exemestane versus tamoxifen in premenopausal women with early breast cancer undergoing ovarian suppression (TEXT and SOFT): a combined analysis of two phase 3 randomised trials.
Walley et al., Bern, Switzerland. In Lancet Oncol, Jul 2015
METHODS: Between Nov 7, 2003, and April 7, 2011, 4717 premenopausal women with hormone-receptor positive breast cancer were enrolled in TEXT or SOFT to receive unmasked adjuvant treatment with 5 years of exemestane plus OFS or tamoxifen plus OFS.
An instructive role for C. elegans E-cadherin in translating cell contact cues into cortical polarity.
Nance et al., New York City, United States. In Nat Cell Biol, Jun 2015
Here we show that the E-cadherin HMR-1, which is dispensable for adhesion, functions together with the α-catenin HMP-1, the p120 catenin JAC-1, and the previously uncharacterized linker PICC-1 (human CCDC85A-C) to bind PAC-1 and recruit it to contacts.
Overcoming Endocrine Resistance in Hormone-Receptor Positive Advanced Breast Cancer-The Emerging Role of CDK4/6 Inhibitors.
O'Sullivan, United States. In Int J Cancer Clin Res, 2014
Results from phase I, II and III trials in hormone-receptor (HR)-positive breast cancer have been encouraging, demonstrating convincing efficacy and a tolerable side-effect profile (mainly uncomplicated neutropenia).
Plant peptide hormone signalling.
Ishida et al., Kumamoto, Japan. In Essays Biochem, 2014
Peptide hormone-receptor complexes activate intracellular signalling through downstream molecules, including kinases and transcription factors, which then trigger cellular events.
Quality Characteristics of Beef by Different Cooking Methods for Frozen Home Meal Replacements.
Choi et al., Seoul, South Korea. In Korean J Food Sci Anim Resour, 2014
Blanching beef for use in home meal replacements (HMR) is an important process that determines the final quality of the beef after the cooking process.
Dual function of Pin1 in NR4A nuclear receptor activation: enhanced activity of NR4As and increased Nur77 protein stability.
de Vries et al., Amsterdam, Netherlands. In Biochim Biophys Acta, 2012
Pin1 enhances the transcriptional activity of all three NR4A nuclear receptors and increases protein stability of Nur77 through inhibition of its ubiquitination.
Differences in NGFI-B, Nurr1, and NOR-1 expression and nucleocytoplasmic translocation in glutamate-treated neurons.
Paulsen et al., Oslo, Norway. In Neurochem Int, 2012
investigated mRNA expression and subcellular translocation of the NR4A proteins during glutamate excitotoxicity in rat cerebellar granule neurons. NGFI-B and Nurr1 mRNA, but not NOR-1 mRNA, were induced by treatments associated with calcium influx
NUR77 inhibits the expression of TIMP2 and increases the migration and invasion of HTR-8/SVneo cells induced by CYR61.
Hu et al., Nanjing, China. In Placenta, 2012
cysteine-rich angiogenic inducer 61 may promote trophoblast cell migration and invasion through upregulation of NUR77 protein leading to the increase of matrix metalloproteinase 2(MMP2) release and the downregulation of tissue inhibitor of MMP2 expression
Angiopoietin-1 and vascular endothelial growth factor regulation of leukocyte adhesion to endothelial cells: role of nuclear receptor-77.
Hussain et al., Montréal, Canada. In Arterioscler Thromb Vasc Biol, 2012
Nur77 promotes anti-inflammatory effects of Ang-1, and functions as a negative feedback inhibitor of VEGF-induced endothelial cell activation.
Testicular steroidogenesis is locally regulated by androgen via suppression of Nur77.
Lee et al., Kwangju, South Korea. In Biochem Biophys Res Commun, 2012
liganded androgen receptor suppresses the transcriptional activity of Nur77 on steroidogenic enzyme gene promoters, affecting testicular steroidogenesis.
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