Pooled Analysis of the Prognostic Relevance of Circulating Tumor Cells in Primary Breast Cancer.
Anderson, United States. In Clin Cancer Res, Feb 2016
Multivariate Cox regressions, which included tumor size, nodal status, histological tumor grade, and hormone-receptor and HER2 status, confirmed that the presence of CTCs was an independent prognostic factor for disease-free survival (hazard ratio (HR), 1.82; 95% confidence interval (CI), 1.47 to 2.26), distant disease-free survival (HR, 1.89; 95% CI, 1.49 to 2.40), breast cancer-specific survival (HR, 2.04; 95% CI, 1.52 to 2.75), and overall survival (HR, 1.97; 95% CI, 1.51 to 2.59).
Prospective Validation of a 21-Gene Expression Assay in Breast Cancer.
United States. In N Engl J Med, Dec 2015
METHODS: We performed a prospective trial involving women with hormone-receptor-positive, human epidermal growth factor receptor type 2 (HER2)-negative, axillary node-negative breast cancer with tumors of 1.1 to 5.0 cm in the greatest dimension (or 0.6 to 1.0 cm in the greatest dimension and intermediate or high tumor grade) who met established guidelines for the consideration of adjuvant chemotherapy on the basis of clinicopathologic features.
Competitive Agonists and Antagonists of Steroid Nuclear Receptors: Evolution of the Concept or Its Reversal.
Moscow, Russia. In Biochemistry (mosc), Oct 2015
Mechanisms of in vitro action for mixed agonist/antagonist steroids are discussed depending on: specific features of their interaction with receptor hormone-binding pocket; steroid-dependent allosteric modulation of interaction between hormone-receptor complex and hormone response DNA elements; features of interacting hormone-receptor complex with protein transcriptional coregulators; level and tissue-specific composition of transcriptional coregulators.
Optimizing Endocrine Therapy for Breast Cancer.
Atlanta, United States. In J Natl Compr Canc Netw, Aug 2015
Endocrine therapy has significantly improved outcomes for patients with early- and advanced-stage hormone-receptor (HR)-positive breast cancer.
Plant peptide hormone signalling.
Kumamoto, Japan. In Essays Biochem, 2014
Peptide hormone-receptor complexes activate intracellular signalling through downstream molecules, including kinases and transcription factors, which then trigger cellular events.