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Hook homolog 1

Hook1, hHK-1
This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, Actin, Inactive, substance P
Papers on Hook1
Membrane-induced structure of novel human tachykinin hemokinin-1 (hHK1).
Cowsik et al., Bengaluru, India. In Biopolymers, Dec 2015
Thus the report provides a structural insight to study hHK-1-NK1 interaction that is essential for hHK1 based signaling events.
SHP2 positively regulates TGFβ1-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1.
Ke et al., Hangzhou, China. In J Biol Chem, 2015
Using the protein-tyrosine phosphatase domain of SHP2 as bait, we identified a novel SHP2-interacting protein Hook1.
Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation.
Holzer et al., Leipzig, Germany. In Plos One, 2014
In this study we show that Hook1 and Hook3 are expressed in neurons while Hook2 is predominantly expressed in astrocytes.
Integrated regulation of motor-driven organelle transport by scaffolding proteins.
Holzbaur et al., Philadelphia, United States. In Trends Cell Biol, 2014
Recent progress demonstrates that organelle-associated scaffolding proteins, including Milton/TRAKs (trafficking kinesin-binding protein), JIP1, JIP3 (JNK-interacting proteins), huntingtin, and Hook1, interact with molecular motors to coordinate activity and sustain unidirectional transport.
Addition of lysophosphatidic acid to mouse oocyte maturation media can enhance fertilization and developmental competence.
Kim et al., South Korea. In Hum Reprod, 2014
PARTICIPANTS/MATERIALS, SETTING, METHODS: Immature GV stage oocytes from 5- to 6-week-old female BDF-1 mice were incubated for 17-18 h in IVM medium containing 0, 1, 10 or 30 μM LPA and then either fertilized in vitro with epididymal sperm, or assessed for spindle morphology, mitochondrial membrane potential (ΔΨm) or the mRNA expression of a meiotic checkpoint gene (Mad2), a microtubule structure gene (Hook1), two maternally derived genes (Mater and Hsf1) and an apoptosis-related gene (Caspase6).
Hemokinin-1(4-11)-induced analgesia selectively up-regulates δ-opioid receptor expression in mice.
Mou et al., Hangzhou, China. In Plos One, 2013
Our previous studies have shown that an active fragment of human tachykinins (hHK-1(4-11)) produced an opioid-independent analgesia after intracerebroventricular (i.c.v.) injection in mice, which has been markedly enhanced by a δ OR antagonist, naltrindole hydrochloride (NTI).
[Molecular genetic mechanisms of teratozoospermia].
Wang et al., Changchun, China. In Zhonghua Nan Ke Xue, 2013
Aiming to provide some evidence for the pathogenesis of teratozoospermia, this paper reviews the relevant literature in the past five years addressing such special teratozoospermia as globozoospermia, nuclear vacuoles, decapitated spermatozoa, excessive residual cytoplasm, dysplasia of the fibrous sheath, and primary ciliary dyskinesia, and elaborates on the molecular genetic mechanisms of DPY19L2, AR, PRM1, GBA2, PCI, CREM, TH2A, TH2B, ODF1, Cntrob, OAZ-t, HOOK1, SPEM1, GAT1, PRSS21, 15-LOX, Sptrx, AKAP3, AKAP4, DNAI1, DNAH5, RSPH4A, TXNDC3, CCDC39, LRRC6, LRRC50, KTU and so on.
Hook1, microtubules, and Rab22: mediators of selective sorting of clathrin-independent endocytic cargo proteins on endosomes.
Donaldson et al., Bethesda, United States. In Bioarchitecture, 2013
In a recent study, we identified sorting signals that specify the endosomal trafficking of CIE cargo proteins and uncover a role for Hook1 as an endosomal cargo adaptor that routes CIE cargo to the recycling endosomes.
Microtubule-dependent endosomal sorting of clathrin-independent cargo by Hook1.
Donaldson et al., Bethesda, United States. In J Cell Biol, 2013
We found that Hook1, a microtubule- and cargo-tethering protein, recognized the cytoplasmic tail of CD147 to help sort it and CD98 into Rab22a-dependent tubules associated with recycling.
Neurokinin-1 receptor directly mediates glioma cell migration by up-regulation of matrix metalloproteinase-2 (MMP-2) and membrane type 1-matrix metalloproteinase (MT1-MMP).
Wang et al., Lanzhou, China. In J Biol Chem, 2013
In this study, we found human hemokinin-1 (hHK-1), via NK1R, dose-dependently promoted the migration of U-251 and U-87 cells.
Hypermethylation of TUSC5 genes in breast cancer tissue.
Zaporozhan et al., Odesa, Ukraine. In Exp Oncol, 2012
While genes TFF1, S100P, ERBB2, TOP2A, CDF15, HOOK1, DNAJC12, CORO2A were up-regulated in cancer, decreased expression was found for genes TUSC5, SFRP1, PPPQR1B, NTRK4, TIMP4, BARD1, AKR1C2, TP53INK1 and others.
Hemokinins modulate endothelium function and promote angiogenesis through neurokinin-1 receptor.
Wang et al., Lanzhou, China. In Int J Biochem Cell Biol, 2012
For the first time, here we demonstrated that r/mHK-1, hHK-1 and hHK(4-11) dose-dependently stimulated the proliferation, migration, adhesion and tube formation of freshly isolated human umbilical vein endothelial cells (HUVECs), and further exhibited in vivo angiogenic effects in chick embryo chorioallantoic membrane model.
Effect of antifreeze protein supplementation in vitrification medium on mouse oocyte developmental competence.
Suh et al., South Korea. In Fertil Steril, 2011
Both vitrification groups showed increased Hsf1, Zar1, and Zp1/Zp2 expression and decreased Hook1 and Zp3 expression compared with fresh control samples.
Cytoskeletal track selection during cargo transport in spermatids is relevant to male fertility.
Tres et al., New York City, United States. In Spermatogenesis, 2011
The acroplaxome plate harbors F-actin and actin-like proteins as well as several other proteins, including keratin 5/Sak57, Ran GTPase, Hook1, dynactin p150Glued, cenexin-derived ODF2, testis-expressed profilin-3 and profilin-4, testis-expressed Fer tyrosine kinase (FerT), members of the ubiquitin-proteasome system and cortactin.
An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex.
Harper et al., Boston, United States. In Mol Biol Cell, 2008
These data suggest that the FTS/Hook/FHIP complex functions to promote vesicle trafficking and/or fusion via the homotypic vacuolar protein sorting complex.
Preservation of ejaculated mouse spermatozoa from fertile C57BL/6 and infertile Hook1/Hook1 mice collected from the uteri of mated females.
Ward et al., Honolulu, United States. In Biol Reprod, 2007
Multiple samples of ejaculated spermatozoa from normal fertile C57BL/6 and infertile Hook1/Hook1 (formerly known as azh/azh) mutant males from uteri after mating.
Elevation of Hook1 in a disease model of Batten disease does not affect a novel interaction between Ankyrin G and Hook1.
Pearce et al., Rochester, United States. In Biochem Biophys Res Commun, 2005
Hook1 and Ankyrin G are co-locolized, Hook1 also localizes to additional regions of the cell devoid of Ankyrin G where it interacts with other proteins.
Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway.
Jalanko et al., Helsinki, Finland. In Hum Mol Genet, 2005
novel interactions between the microtubule-binding Hook1 and the large family of Rab GTPases also suggest a link between CLN3 function, microtubule cytoskeleton and endocytic membrane trafficking
Hemokinins and endokinins.
Page, Reading, United Kingdom. In Cell Mol Life Sci, 2004
This group includes hemokinin-1 (HK-1) in mouse and rat, endokinin-1 (EK-1) in rabbit, and EKA, EKB, human HK-1 (hHK-1) and hHK(4-11) in humans.
The Hook1 gene is non-functional in the abnormal spermatozoon head shape (azh) mutant mouse.
Neesen et al., Göttingen, Germany. In Hum Mol Genet, 2002
azh mutation is due to a deletion of exons 10 and 11 in the murine Hook1 gene leading to a non-functional protein. Our results indicate that loss of Hook1 function results in ectopic positioning of microtubular structures within the spermatid
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