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Kallikrein-related peptidase 8

HNP, KLK8, Neuropsin, hK8, kallikrein 8
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in four transcript variants encoding four different isoforms. The isoforms exhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Defensin, Kallikrein, HAD, CAN, ACID
Papers on HNP
Injectable hydrogel provides growth-permissive environment for human nucleus pulposus cells.
Yao et al., Wichita, United States. In J Biomed Mater Res A, Feb 2016
This study suggests that the type II collagen-HA hydrogel and crosslinked hydrogel (0.1 mM EDC) are permissive matrix for the growth of HNP cells and can be potentially applied in NP repair.
Mono-2-ethylhexyl phthalate (MEHP) alters histiotrophic nutrition pathways and epigenetic processes in the developing conceptus.
Harris et al., Ann Arbor, United States. In J Nutr Biochem, Jan 2016
Specifically, 3-h MEHP treatment of mouse EMBs in whole culture resulted in dose-dependent reduction of HNP activity in the conceptus.
Influence of Storage Conditions on MALDI-TOF MS Profiling of Gingival Crevicular Fluid: Implications on the Role of S100A8 and S100A9 for Clinical and Proteomic based Diagnostic Investigations.
Terracciano et al., Catanzaro, Italy. In Proteomics, Jan 2016
Noteworthy, a significant decrease in the peak area of HNP-3, S100A8, full-length S100A9 and its truncated form were detected after 3 months at -80°C.
Redox-Triggered Gatekeeper-Enveloped Starlike Hollow Silica Nanoparticles for Intelligent Delivery Systems.
Xu et al., Beijing, China. In Small, Dec 2015
Compared with ordinary spherical HNP-based counterparts, SHNP-PGEA carriers with six sharp horns are proven to be superior gene vectors and possess better efficacy for cellular uptake and antitumor effects.
The GraS Sensor in Staphylococcus aureus Mediates Resistance to Host Defense Peptides Differing in Mechanisms of Action.
Yeaman et al., Ansŏng, South Korea. In Infect Immun, Dec 2015
Null mutants in the GraS holoprotein (ΔgraS) or its EL (ΔEL) were compared for mechanisms of resistance to HDPs of relevant immune sources: neutrophil α-defensin, hNP-1, cutaneous β-defensin, hBD-2 or the platelet kinocidin congener, RP-1.
Identification of innate immune antiretroviral factors during in vivo and in vitro exposure to HIV-1.
Rugeles et al., Medellín, Colombia. In Microbes Infect, Dec 2015
Human neutrophil peptide 1 (hNP-1), human beta defensin (hBD) 2 and 3, RNases, MIP-1β and RANTES mRNA transcripts were quantified by qPCR and in vitro single-round, recombinant-based viral infectivity assay was used to evaluate the anti-HIV-1 activity of hBDs and RNases.
Novel RNA variants in colorectal cancers.
Skotheim et al., Oslo, Norway. In Oncotarget, Dec 2015
These include a recurrent read-through fusion transcript between KLK8 and KLK7, and a splice variant of S100A2.
Analyses of Gingival Adhesion Molecules in Periodontitis: Theoretical in Silico, Comparative in Vivo, and Explanatory in Vitro Models.
Könönen et al., Turku, Finland. In J Periodontol, Nov 2015
We report here 1) an in silico network model of interactions among cell adhesion molecules and a network-focused microarray analysis of the corresponding genes in periodontitis, 2) analysis of secretions of adhesion molecules in gingival tissue samples from patients with periodontitis and healthy controls, and 3) effect of the human neutrophilic peptide (HNP)-1 on epithelial adhesion molecules.
Antimicrobial Peptides in Human Sepsis.
Schuerholz et al., Aachen, Germany. In Front Immunol, 2014
Human neutrophil peptides (HNP) 1-3 and human beta-defensins (HBDs) 1-3 are some of the most important defensins in humans.
[Mechanisms of resistance of enterococci to antimicrobial proteins and peptides].
Valyshev et al., In Zh Mikrobiol Epidemiol Immunobiol, 2012
Evidence on microbial activation/degradation of neutrophil alpha-defensin (HNP-1), antibacterial peptide LL-37, cecropin, beta-lysine (thrombocytic cationic peptide) is presented.
NGF-p75 and neuropsin/KLK8 pathways stimulate each other to cause hyperkeratosis and acanthosis in inflamed skin.
Tohyama et al., In J Dermatol Sci, 2012
Letter: NGF-p75 and neuropsin/KLK8 pathways may cooperate in regulation of epidermal homeostasis in inflamed skin.
Kallikrein-related peptidase 8-dependent skin wound healing is associated with upregulation of kallikrein-related peptidase 6 and PAR2.
Yoshida et al., Asahikawa, Japan. In J Invest Dermatol, 2012
Klk8 is involved in the proliferation and migration of keratinocytes through Klk6 in the early stages of wound healing, and possibly in keratinocyte differentiation associated with the upregulation of PAR2 in the late stages of wound healing.
Proteinase-activated receptors (PARs): differential signalling by kallikrein-related peptidases KLK8 and KLK14.
Hollenberg et al., Calgary, Canada. In Biol Chem, 2012
KLK8 and KLK14 can signal differentially via the PARs to affect tissue function
Neuropsin--a possible modulator of synaptic plasticity.
Ishikawa et al., Ikoma, Japan. In J Chem Neuroanat, 2011
Among such proteases, neuropsin, a kallikrein gene-related (KLK) endoprotease, appears to have a significant plasticity function that has been analyzed primarily in the hippocampal Schaffer-collateral pathway.
Diversity of neuropsin (KLK8)-dependent synaptic associativity in the hippocampal pyramidal neuron.
Shiosaka et al., Ikoma, Japan. In J Physiol, 2011
KLK8 is involved in synaptic tagging during LTP at basal and apical dendritic inputs.
Neuropsin cleaves EphB2 in the amygdala to control anxiety.
Pawlak et al., Leicester, United Kingdom. In Nature, 2011
the serine protease neuropsin is critical for stress-related plasticity in the amygdala by regulating the dynamics of the EphB2-NMDA-receptor interaction, the expression of Fkbp5 and anxiety-like behaviour
UV-sensitive photoreceptor protein OPN5 in humans and mice.
Fukada et al., Tokyo, Japan. In Plos One, 2010
OPN5 was capable of activating heterotrimeric G protein Gi in a UV-dependent manner
Klk8, a multifunctional protease in the brain and skin: analysis of knockout mice.
Yoshida, Asahikawa, Japan. In Biol Chem, 2010
Klk8 might thus be involved in tissue development and rearrangement.
Head and neck paragangliomas in von Hippel-Lindau disease and multiple endocrine neoplasia type 2.
Neumann et al., Freiburg, Germany. In J Clin Endocrinol Metab, 2009
Heritable non-SDHx HNP might occur in von Hippel-Lindau disease (VHL, VHL gene), multiple endocrine neoplasia type 2 (MEN2, RET gene), and neurofibromatosis type 1 (NF1, NF1 gene).
Predictors and prevalence of paraganglioma syndrome associated with mutations of the SDHC gene.
European-American Paraganglioma Study Group et al., Padova, Italy. In Jama, 2005
DESIGN, SETTING, AND PATIENTS: Genetic screening for SDHC mutations in an international HNP registry of 121 unrelated index cases and in 371 sporadic cases from a pheochromocytoma registry, conducted January 1, 2001, until December 31, 2004.
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