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Hepatocyte nuclear factor 4, gamma

HNF4gamma, HNF4G, hepatocyte nuclear factor 4 gamma, NR2A2
Top mentioned proteins: TCF, CAN, ACID, HNF1, HAD
Papers on HNF4gamma
Benchmarking database performance for genomic data.
Khushi, Westmead, Australia. In J Cell Biochem, Jun 2015
In addition, using the algorithm pair-wise, overlaps of >1000 datasets of transcription factor binding sites and histone marks, collected from previous publications, were reported and it was found that HNF4G significantly co-locates with cohesin subunit STAG1 (SA1).Inc.
Silencing of long noncoding RNA MALAT1 by miR-101 and miR-217 inhibits proliferation, migration, and invasion of esophageal squamous cell carcinoma cells.
Yang et al., Beijing, China. In J Biol Chem, Mar 2015
This might be attributed to the deregulation of downstream genes of MALAT1, such as MIA2, HNF4G, ROBO1, CCT4, and CTHRC1.
miR-34a inhibits proliferation and invasion of bladder cancer cells by targeting orphan nuclear receptor HNF4G.
Yang et al., Jinan, China. In Dis Markers, 2014
This study explored the regulative role of miR-34a on an orphan nuclear receptor HNF4G, which has a well-confirmed role in bladder tumor growth and invasion.
A marker-derived gene network reveals the regulatory role of PPARGC1A, HNF4G, and FOXP3 in intramuscular fat deposition of beef cattle.
Reverter et al., Jouy-le-Moutier, France. In J Anim Sci, 2014
Pathway and network analyses pointed towards a trio of transcription factors (TF) as key regulators of carcass IMF: PPARGC1A, HNF4G, and FOXP3.
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
Ingelsson et al., Bethesda, United States. In Nat Genet, 2013
In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity.
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
Gieger et al., Freiburg, Germany. In Nat Genet, 2013
By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4).
Orphan nuclear receptor HNF4G promotes bladder cancer growth and invasion through the regulation of the hyaluronan synthase 2 gene.
Hara et al., Kami-renjaku, Japan. In Oncogenesis, 2012
First, we examined the expression levels of 22 genes encoding orphan NRs in clinical bladder cancer and found that hepatocyte nuclear factor 4γ (HNF4G; NR2A2) and NR2F6 were the genes that were upregulated most frequently in cancer tissues compared with their paired normal tissues.
Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer.
Stolzenberg-Solomon et al., Houston, United States. In Carcinogenesis, 2012
The most significant genes (P < 0.01) in the five pathways were NR5A2, HNF1A, HNF4G and PDX1 for pancreatic development; ABO for H.pylori lacto/neolacto; SHH for hedgehog; TGFBR2 and CCL18 for Th1/Th2 immune response and MAPK8 and BCL2L11 for apoptosis.
Proteomic analysis of native hepatocyte nuclear factor-4α (HNF4α) isoforms, phosphorylation status, and interactive cofactors.
Hamakubo et al., Tokyo, Japan. In J Biol Chem, 2011
Heterodimerization of HNF4alpha and HNF4gamma was found
Germ line transmission and expression of an RNAi cassette in mice generated by a lentiviral vector system.
Schütz et al., Heidelberg, Germany. In Transgenic Res, 2007
We have used a lentiviral delivery system (LentiLox3.7) to generate transgenic mice harbouring RNA interference (RNAi) against the hepatocyte nuclear factor 4 gamma (HNF4gamma).
Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis.
Chakravarti et al., Baltimore, United States. In Inflamm Bowel Dis, 2007
The most noticeable change in the UC samples was reduced expression of genes regulating biosynthesis, metabolism, and electrolyte transport (HNF4G, KLF5, AQP8, ATP2B1, and SLC16A).
Systematic association mapping identifies NELL1 as a novel IBD disease gene.
Schreiber et al., Kiel, Germany. In Plos One, 2006
Several associations were replicated in at least one independent sample, point to an involvement of ITGB6 (upstream), GRM8 (downstream), OR5V1 (downstream), PPP3R2 (downstream), NM_152575 (upstream) and HNF4G (intron).
Phenotypic screening of hepatocyte nuclear factor (HNF) 4-gamma receptor knockout mice.
Bohlooly-Y et al., Mölndal, Sweden. In Biochem Biophys Res Commun, 2006
HNF4g has a role in energy expenditure, locomotor activity during night time, and higher body weight
Microarray and real-time RT-PCR analyses of a novel set of differentially expressed human genes in ECV304 endothelial-like cells infected with dengue virus type 2.
Chow et al., Singapore, Singapore. In J Virol Methods, 2006
Quantitative real-time RT-PCR was then performed to determine the expression patterns of 15 selected genes of interest involved in the cell cycle (MAD3), apoptosis (RIPK3, PDCD8), cellular receptors (H963, CCR7, KLRC3), transcriptional regulation (RUNX3, HNF4G, MIZ1), signal transduction (HSP27, TRIP, MAP4K4), enzymes (angiotensinogen), protein transport (AP4M1), and cytoskeleton (ACTA2).
Distinct amino acid residues may be involved in coactivator and ligand interactions in hepatocyte nuclear factor-4alpha.
Hadzopoulou-Cladaras et al., Thessaloníki, Greece. In J Biol Chem, 2005
Crystallographic analysis of the HNF-4alpha and HNF-4gamma ligand binding domains (LBDs) demonstrated the presence of endogenous ligands that may act as structural cofactors for HNF-4.
Expression of growth hormone receptor 1A mRNA is decreased in dairy cows but not in beef cows at parturition.
Beal et al., Blacksburg, United States. In J Dairy Sci, 2005
The promoter controlling expression of a major bovine growth hormone (GH) receptor (GHR) mRNA variant, GHR 1A, contains a common DNA element for transcription factors hepatocyte nuclear factor 4alpha (HNF-4alpha), hepatocyte nuclear factor 4gamma (HNF-4gamma), and chicken ovalbumin transcription factor II (COUP-TFII).
Tissue-specific mRNA expression profiles of human nuclear receptor subfamilies.
Yokoi et al., Naruto, Japan. In Drug Metab Pharmacokinet, 2004
NR2A2 mRNA was detected in the liver, kidney, prostate, testis, uterus, and trachea.
Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers.
Kamataki et al., Sapporo, Japan. In Pharmacogenetics, 2003
results suggest that the expression level of dihydrodiol dehydrogenase 4 mRNA is cooperatively regulated by the amounts of HNF-1 alpha, HNF-4 alpha and HNF-4 gamma
Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids.
Williams et al., United States. In Structure, 2002
2.7 A X-ray crystalography results suggest that the HNF4s may be transcription factors that are constitutively bound to fatty acids
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