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High mobility group AT-hook 2

This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, POLYMERASE, HMGA1a, V1a
Papers on HMGA2
Gene expression in prolactinomas: a systematic review.
Carmichael et al., Los Angeles, United States. In Pituitary, Feb 2016
Of the many genes identified, three upregulated (HMGA2, HST, SNAP25), and three downregulated (UGT2B7, Let7, miR-493) genes were selected for further analysis based on our subjective identification of strong potential targets.
Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers.
Aaltonen et al., Helsinki, Finland. In Proc Natl Acad Sci U S A, Feb 2016
In this study, we explored transcriptional differences among leiomyomas harboring different genetic drivers, including high mobility group AT-hook 2 (HMGA2) rearrangements, mediator complex subunit 12 (MED12) mutations, biallelic inactivation of fumarate hydratase (FH), and collagen, type IV, alpha 5 and collagen, type IV, alpha 6 (COL4A5-COL4A6) deletions.
Let-7a suppresses glioma cell proliferation and invasion through TGF-β/Smad3 signaling pathway by targeting HMGA2.
Ma et al., Changchun, China. In Tumour Biol, Jan 2016
Our study was designed to infer how let-7a targets high-mobility AT-hook 2 (HMGA2) and suppresses glioma cell proliferation, invasion, and migration.
Meta-analysis of Complex Diseases at Gene Level by Generalized Functional Linear Models.
Xiong et al., Houston, United States. In Genetics, Jan 2016
The GFLMs were applied to analyze genetic data of 22 gene regions of type 2 diabetes data from a meta-analysis of eight European studies, and detected significant association for 18 genes (p-values < 3.10x10(-6)) and tentative association for 2 genes (HHEX and HMGA2, p-values around 10(-5)) and no association for 2 genes, while MetaSKAT detected none.
A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer.
Turkson et al., Honolulu, United States. In Oncotarget, Jan 2016
Moreover, analyses of human pancreatic ductal adenocarcinoma (PDAC) tumor tissues detected the association of nuclear Src with the HMGA2 and SMYD3 gene promoters.
Epigallocatechin-3-O-gallate up-regulates microRNA-let-7b expression by activating 67-kDa laminin receptor signaling in melanoma cells.
Tachibana et al., Fukuoka, Japan. In Sci Rep, Dec 2015
The EGCG-induced up-regulation of let-7b led to down-regulation of high mobility group A2 (HMGA2), a target gene related to tumor progression.
Myeloproliferative neoplasms: Current molecular biology and genetics.
Saeidi, Kermān, Iran. In Crit Rev Oncol Hematol, Dec 2015
Some other genes' location such as TET oncogene family member 2 (TET2), additional sex combs-like 1 (ASXL1), casitas B-lineage lymphoma proto-oncogene (CBL), isocitrate dehydrogenase 1/2 (IDH1/IDH2), IKAROS family zinc finger 1 (IKZF1), DNA methyltransferase 3A (DNMT3A), suppressor of cytokine signaling (SOCS), enhancer of zeste homolog 2 (EZH2), tumor protein p53 (TP53), runt-related transcription factor 1 (RUNX1) and high mobility group AT-hook 2 (HMGA2) have also identified to be involved in MPNs phenotypes.
Molecular cytogenetics of pediatric adipocytic tumors.
Pedeutour et al., Nice, France. In Cancer Genet, Oct 2015
Similar to adult cases, most of these pediatric lipomas harbored rearrangements of the chromosomal regions 12q14-q15 and 6p21, involving the HMGA2 and HMGA1 genes.
Lipo-chitooligosaccharidic nodulation factors and their perception by plant receptors.
Bono et al., France. In Glycoconj J, Oct 2015
Lipo-chitooligosaccharides produced by nitrogen-fixing rhizobia are signaling molecules involved in the establishment of an important agronomical and ecological symbiosis with plants.
Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism.
Ma et al., Wuhan, China. In Nat Genet, Feb 2015
Beyond recalculating frequencies for the previously reported frequent integration sites POU5F1B (9.7%), FHIT (8.7%), KLF12 (7.8%), KLF5 (6.8%), LRP1B (5.8%) and LEPREL1 (4.9%), we discovered new hot spots HMGA2 (7.8%), DLG2 (4.9%) and SEMA3D (4.9%).
Epigenetic Mechanisms Leading to Overexpression of HMGA Proteins in Human Pituitary Adenomas.
Fusco et al., Napoli, Italy. In Front Med (lausanne), 2014
Overexpression of the high-mobility group A (HMGA)1 and HMGA2 proteins is a feature of all human pituitary adenoma (PAs) subtypes.
HMGA2 functions as a competing endogenous RNA to promote lung cancer progression.
Downward et al., Stanford, United States. In Nature, 2014
Hmga2 is highly expressed in metastatic lung adenocarcinoma, in which it contributes to cancer progression and metastasis.
Characterization of uterine leiomyomas by whole-genome sequencing.
Aaltonen et al., Helsinki, Finland. In N Engl J Med, 2013
The rearrangements created tissue-specific changes consistent with a role in the initiation of leiomyoma, such as translocations of the HMGA2 and RAD51B loci and aberrations at the COL4A5-COL4A6 locus, and occurred in the presence of normal TP53 alleles.
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
Early Growth Genetics (EGG) Consortium et al., Oxford, United Kingdom. In Nat Genet, 2013
Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height.
Altered microRNA expression profile in human pituitary GH adenomas: down-regulation of miRNA targeting HMGA1, HMGA2, and E2F1.
Fusco et al., Napoli, Italy. In J Clin Endocrinol Metab, 2012
Down-regulation of miRNA targeting HMGA1, HMGA2, and E2F1 in human pituitary GH adenomas.
t(12;13)(q14;q31) leading to HMGA2 upregulation in acute myeloid leukaemia.
Micci et al., In Br J Haematol, 2012
t(12;13)(q14;q31) leading to HMGA2 upregulation in acute myeloid leukaemia.
HMGA2 protein expression in ovarian serous carcinoma effusions, primary tumors, and solid metastases.
Davidson et al., Oslo, Norway. In Virchows Arch, 2012
This study provides evidence that HMGA2 is universally expressed in advanced-stage ovarian serous carcinoma irrespective of anatomic site
The expression of HMGA2 varies strongly among colon carcinomas.
Bullerdiek et al., Heidelberg, Germany. In Anticancer Res, 2012
overexpression of HMGA2, compared to adjacent mucosa, is not consistent among colon carcinomas
Identification of common variants associated with human hippocampal and intracranial volumes.
Enhancing Neuro Imaging Genetics through Meta-Analysis Consortium et al., Los Angeles, United States. In Nat Genet, 2012
Additionally, rs10784502, located within HMGA2, was associated with intracranial volume (12q14.3;
HMGA2 is commonly expressed in uterine serous carcinomas and is a useful adjunct to diagnosis.
Gilks et al., Ireland. In Histopathology, 2012
HMGA2 may be of value in problematic uterine carcinomas where the differential diagnosis includes serous and endometrioid carcinoma. As
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