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High mobility group AT-hook 1

This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HMGA2, CAN, Histone, HAD, Insulin
Papers using HMGA1a antibodies
Antagonism of Myc functions by Arf
Resar Linda MS et al., In BMC Genomics, 2003
... HMGA1 transgenic mice at 2 months with ...
Papers on HMGA1a
Association of ICAM-1 and HMGA1 Gene Variants with Retinopathy in Type 2 Diabetes Mellitus Among Chinese Individuals.
Qu et al., Jinan, China. In Curr Eye Res, Jan 2016
PURPOSE: To evaluate the association of intercellular cell-adhesion molecule 1 (ICAM-1) and high-mobility group A1 (HMGA1) gene variants with diabetic retinopathy (DR) in a Chinese type 2 diabetes mellitus (T2DM) cohort.
Fusion of the TBL1XR1 and HMGA1 genes in splenic hemangioma with t(3;6)(q26;p21).
Heim et al., Oslo, Norway. In Int J Oncol, Jan 2016
UNASSIGNED: RNA-sequencing of a splenic hemangioma with the karyotype 45~47,XX,t(3;6)(q26;p21) showed that this translocation generated a chimeric TBL1XR1-HMGA1 gene.
ROS-activated ATM-dependent phosphorylation of cytoplasmic substrates identified by large scale phosphoproteomics screen.
Lavin et al., Australia. In Mol Cell Proteomics, Jan 2016
Two of these 11 were previously described as ATM substrates (HMGA1 and UIMCI/RAP80), another five were identified in a whole cell extract phosphoproteomic screens and the remaining four proteins had not been identified previously in DNA damage response screens.
Role of High-mobility Group Protein A Isoforms and Their Clinicopathologic Significance in Primary Retinoblastoma.
Kashyap et al., New Delhi, India. In Appl Immunohistochem Mol Morphol, Jan 2016
Increased expression of HMGA1 and HMGA2 has been reported in various benign and malignant tumors.
Molecular cytogenetics of pediatric adipocytic tumors.
Pedeutour et al., Nice, France. In Cancer Genet, Oct 2015
Similar to adult cases, most of these pediatric lipomas harbored rearrangements of the chromosomal regions 12q14-q15 and 6p21, involving the HMGA2 and HMGA1 genes.
Epigenetic Mechanisms Leading to Overexpression of HMGA Proteins in Human Pituitary Adenomas.
Fusco et al., Napoli, Italy. In Front Med (lausanne), 2014
However, amplification and/or rearrangement of the HMGA2 have been described in human prolactinomas, but rarely in other pituitary subtypes, and no genomic amplification of HMGA1 was detected in PAs.
RNA-Mediated Regulation of HMGA1 Function.
Eilebrecht et al., In Biomolecules, 2014
The high mobility group protein A1 (HMGA1) is a master regulator of chromatin structure mediating its major gene regulatory activity by direct interactions with A/T-rich DNA sequences located in the promoter and enhancer regions of a large variety of genes.
HMGA1-pseudogene overexpression contributes to cancer progression.
Fusco et al., Napoli, Italy. In Cell Cycle, 2013
Two pseudogenes for HMGA1, whose overexpression has a critical role in cancer progression, have been identified.
Recent advances in molecular and cell biology of testicular germ-cell tumors.
Chieffi, Caserta, Italy. In Int Rev Cell Mol Biol, 2013
Many discovered biomarkers including OCT3/4, SOX2, SOX17, HMGA1, Nek2, GPR30, Aurora-B, estrogen receptor β, and others have given further advantages to discriminate between histological subgroups and could represent useful novel molecular targets for antineoplastic strategies.
The high-mobility group A1-estrogen receptor β nuclear interaction is impaired in human testicular seminomas.
Chieffi et al., Napoli, Italy. In J Cell Physiol, 2012
These results suggest that exposure to estrogens or estrogen-mimics, in some as of yet undefined manner, diminishes the ERbeta-mediated growth restraint in human testicular seminoma.
HMGA regulates the global chromatin state and neurogenic potential in neocortical precursor cells.
Gotoh et al., Tokyo, Japan. In Nat Neurosci, 2012
HMGA1 contributes to the neurogenic potential of neural precursor cells in the early stages of neocortical development.
Altered microRNA expression profile in human pituitary GH adenomas: down-regulation of miRNA targeting HMGA1, HMGA2, and E2F1.
Fusco et al., Napoli, Italy. In J Clin Endocrinol Metab, 2012
Down-regulation of miRNA targeting HMGA1, HMGA2, and E2F1 in human pituitary GH adenomas.
Polymorphism of HMGA1 is associated with increased risk of type 2 diabetes among Chinese individuals.
Wang et al., Wuhan, China. In Diabetologia, 2012
HMGA1 is an important susceptibility locus that confers a high cross-race risk of the development of type 2 diabetes.
Knockdown of HMGA1 expression by short/small hairpin RNA inhibits growth of ovarian carcinoma cells.
Zhang et al., Harbin, China. In Biotechnol Appl Biochem, 2012
knockdown of HMGA1 expression in OVCAR cells could change cell morphology, decrease cell proliferation, and reduce invasion in vitro
Functional variants of the HMGA1 gene and type 2 diabetes mellitus.
Brunetti et al., Catanzaro, Italy. In Jama, 2011
Compared with healthy controls, the presence of functional HMGA1 gene variants in individuals of white European ancestry was associated with type 2 diabetes mellitus
Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice.
Brunetti et al., Catanzaro, Italy. In Nat Med, 2005
Loss of Hmga1 expression, induced in mice by disrupting the Hmga1 gene, largely impaired insulin signaling and severely reduced insulin secretion, causing a phenotype characteristic of human type 2 diabetes.
Coordination of a transcriptional switch by HMGI(Y) acetylation.
Thanos et al., New York City, United States. In Science, 2001
The enhanceosome activates transcription by recruiting the histone acetyltransferase proteins CREB binding protein (CBP) and p300/CBP-associated factors (PCAF)/GCN5, which, in addition to modifying histones, acetylate HMGI(Y), the architectural component required for enhanceosome assembly.
Expression of High Mobility Group Protein Family [HMGI(Y) and HMGI-C] in Human Breast Cancer.
Kim et al., In Cancer Res Treat, 2001
RESULTS: The expression of the HMGI(Y) mRNA increased more in malignant tissue (90%, 54 of 60) than in benign (76.9%) and normal (65%) tissues (p=0.031).
The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements.
Leonard et al., Bethesda, United States. In Immunity, 2001
PRRIV activity requires GAS motifs that bind Stat5 proteins and additional upstream HMG-I(Y) binding sites.
In vivo modulation of Hmgic reduces obesity.
Chada et al., United States. In Nat Genet, 2000
The HMGI family of proteins consists of three members, HMGIC, HMGI and HMGI(Y), that function as architectural factors and are essential components of the enhancesome.
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